Tags

Type your tag names separated by a space and hit enter

Role of soy protein with normal or reduced isoflavone content in reversing bone loss induced by ovarian hormone deficiency in rats.
Am J Clin Nutr 1998; 68(6 Suppl):1358S-1363SAJ

Abstract

Soy protein, a rich source of isoflavones, fed immediately after an ovariectomy prevents bone loss in rats. Reports of the effectiveness of natural and synthetic isoflavones in preventing or treating osteoporosis led us to examine the effect of soy protein in reversing established bone loss. Seventy-two 95-d-old female Sprague-Dawley rats were assigned to 6 groups. The rats were either sham operated (SHAM; 2 groups) or ovariectomized (OVX; 4 groups) and then fed a casein-based, semipurified diet. Thirty-five days after surgery, 1 SHAM and 1 OVX group were killed to examine the occurrence of bone loss. Thereafter, the other SHAM and 1 OVX groups continued to receive the casein-based diet. Whereas the remaining 2 OVX groups received diets in which casein was replaced by soy protein with normal (OVX+SOY) or reduced (OVX+SOY-) isoflavone content for 65 days. The OVX control group had significantly lower femoral and fourth lumbar vertebral bone densities than the SHAM group. Femoral density of rats fed SOY or SOY- diets were not significantly different from SHAM or OVX controls. This suggests a slight reversal of cortical bone loss that may be partially due to higher femoral insulin-like growth factor I mRNA transcripts resulting from both the SOY and SOY- diets. The ovariectomy-induced increases in indexes of bone turnover were not ameliorated by either of the soy diets, suggesting that any positive effect of soy was achieved through enhanced bone formation rather than slowed bone resorption. Long-term consumption of soy or its isoflavones may be needed to produce small but continued increments in bone mass.

Authors+Show Affiliations

Department of Nutritional Sciences, Oklahoma State University, Stillwater 74078-6141, USA. arjmand@okstate.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9848499

Citation

Arjmandi, B H., et al. "Role of Soy Protein With Normal or Reduced Isoflavone Content in Reversing Bone Loss Induced By Ovarian Hormone Deficiency in Rats." The American Journal of Clinical Nutrition, vol. 68, no. 6 Suppl, 1998, 1358S-1363S.
Arjmandi BH, Getlinger MJ, Goyal NV, et al. Role of soy protein with normal or reduced isoflavone content in reversing bone loss induced by ovarian hormone deficiency in rats. Am J Clin Nutr. 1998;68(6 Suppl):1358S-1363S.
Arjmandi, B. H., Getlinger, M. J., Goyal, N. V., Alekel, L., Hasler, C. M., Juma, S., ... Kukreja, S. C. (1998). Role of soy protein with normal or reduced isoflavone content in reversing bone loss induced by ovarian hormone deficiency in rats. The American Journal of Clinical Nutrition, 68(6 Suppl), 1358S-1363S. doi:10.1093/ajcn/68.6.1358S.
Arjmandi BH, et al. Role of Soy Protein With Normal or Reduced Isoflavone Content in Reversing Bone Loss Induced By Ovarian Hormone Deficiency in Rats. Am J Clin Nutr. 1998;68(6 Suppl):1358S-1363S. PubMed PMID: 9848499.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of soy protein with normal or reduced isoflavone content in reversing bone loss induced by ovarian hormone deficiency in rats. AU - Arjmandi,B H, AU - Getlinger,M J, AU - Goyal,N V, AU - Alekel,L, AU - Hasler,C M, AU - Juma,S, AU - Drum,M L, AU - Hollis,B W, AU - Kukreja,S C, PY - 1998/12/16/pubmed PY - 1998/12/16/medline PY - 1998/12/16/entrez SP - 1358S EP - 1363S JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 68 IS - 6 Suppl N2 - Soy protein, a rich source of isoflavones, fed immediately after an ovariectomy prevents bone loss in rats. Reports of the effectiveness of natural and synthetic isoflavones in preventing or treating osteoporosis led us to examine the effect of soy protein in reversing established bone loss. Seventy-two 95-d-old female Sprague-Dawley rats were assigned to 6 groups. The rats were either sham operated (SHAM; 2 groups) or ovariectomized (OVX; 4 groups) and then fed a casein-based, semipurified diet. Thirty-five days after surgery, 1 SHAM and 1 OVX group were killed to examine the occurrence of bone loss. Thereafter, the other SHAM and 1 OVX groups continued to receive the casein-based diet. Whereas the remaining 2 OVX groups received diets in which casein was replaced by soy protein with normal (OVX+SOY) or reduced (OVX+SOY-) isoflavone content for 65 days. The OVX control group had significantly lower femoral and fourth lumbar vertebral bone densities than the SHAM group. Femoral density of rats fed SOY or SOY- diets were not significantly different from SHAM or OVX controls. This suggests a slight reversal of cortical bone loss that may be partially due to higher femoral insulin-like growth factor I mRNA transcripts resulting from both the SOY and SOY- diets. The ovariectomy-induced increases in indexes of bone turnover were not ameliorated by either of the soy diets, suggesting that any positive effect of soy was achieved through enhanced bone formation rather than slowed bone resorption. Long-term consumption of soy or its isoflavones may be needed to produce small but continued increments in bone mass. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/9848499/Role_of_soy_protein_with_normal_or_reduced_isoflavone_content_in_reversing_bone_loss_induced_by_ovarian_hormone_deficiency_in_rats_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/68.6.1358S DB - PRIME DP - Unbound Medicine ER -