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Bone-sparing effect of soy protein in ovarian hormone-deficient rats is related to its isoflavone content.
Am J Clin Nutr 1998; 68(6 Suppl):1364S-1368SAJ

Abstract

Our previous studies showed that a soy-protein diet prevents ovariectomy-induced bone loss. The purpose of this study was to determine whether isoflavones in soy protein are responsible for this bone-protective effect. Forty-eight 95-d-old Sprague-Dawley rats were divided into 4 groups: sham-operated fed a casein-based diet (SHAM), ovariectomized fed a casein-based diet (OVX+CASEIN), ovariectomized fed soy protein with normal isoflavone content (OVX+SOY), and ovariectomized fed soy protein with reduced isoflavone content (OVX+SOY-). The OVX+SOY group had significantly greater femoral bone density (in g/cm3 bone vol) than the OVX+CASEIN group, whereas OVX+SOY- was similar to OVX+CASEIN (mean +/- SD; SHAM, 1.522 +/- 0.041; OVX+CASEIN, 1.449 +/- 0.044; OVX+SOY, 1.497 +/- 0.030; OVX+SOY-, 1.452 +/- 0.030). Ovariectomy resulted in greater bone turnover as indicated by higher serum alkaline phosphatase activity, serum insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations, and urinary hydroxyproline. These increases were not affected by soy with either normal or reduced isoflavone content. Similarly, histomorphometry revealed a greater bone formation rate with ovariectomy, and this was not altered by the soy diets. The findings of this study suggest that isoflavones in soy protein are responsible for its bone-sparing effects. Further studies to evaluate the mechanism of action of isoflavones on bone are warranted.

Authors+Show Affiliations

Department of Nutritional Sciences, Oklahoma State University, Stillwater 74078-6141, USA. arjmand@okstate.edu

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9848500

Citation

Arjmandi, B H., et al. "Bone-sparing Effect of Soy Protein in Ovarian Hormone-deficient Rats Is Related to Its Isoflavone Content." The American Journal of Clinical Nutrition, vol. 68, no. 6 Suppl, 1998, 1364S-1368S.
Arjmandi BH, Birnbaum R, Goyal NV, et al. Bone-sparing effect of soy protein in ovarian hormone-deficient rats is related to its isoflavone content. Am J Clin Nutr. 1998;68(6 Suppl):1364S-1368S.
Arjmandi, B. H., Birnbaum, R., Goyal, N. V., Getlinger, M. J., Juma, S., Alekel, L., ... Kukreja, S. C. (1998). Bone-sparing effect of soy protein in ovarian hormone-deficient rats is related to its isoflavone content. The American Journal of Clinical Nutrition, 68(6 Suppl), 1364S-1368S. doi:10.1093/ajcn/68.6.1364S.
Arjmandi BH, et al. Bone-sparing Effect of Soy Protein in Ovarian Hormone-deficient Rats Is Related to Its Isoflavone Content. Am J Clin Nutr. 1998;68(6 Suppl):1364S-1368S. PubMed PMID: 9848500.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bone-sparing effect of soy protein in ovarian hormone-deficient rats is related to its isoflavone content. AU - Arjmandi,B H, AU - Birnbaum,R, AU - Goyal,N V, AU - Getlinger,M J, AU - Juma,S, AU - Alekel,L, AU - Hasler,C M, AU - Drum,M L, AU - Hollis,B W, AU - Kukreja,S C, PY - 1998/12/16/pubmed PY - 1998/12/16/medline PY - 1998/12/16/entrez SP - 1364S EP - 1368S JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 68 IS - 6 Suppl N2 - Our previous studies showed that a soy-protein diet prevents ovariectomy-induced bone loss. The purpose of this study was to determine whether isoflavones in soy protein are responsible for this bone-protective effect. Forty-eight 95-d-old Sprague-Dawley rats were divided into 4 groups: sham-operated fed a casein-based diet (SHAM), ovariectomized fed a casein-based diet (OVX+CASEIN), ovariectomized fed soy protein with normal isoflavone content (OVX+SOY), and ovariectomized fed soy protein with reduced isoflavone content (OVX+SOY-). The OVX+SOY group had significantly greater femoral bone density (in g/cm3 bone vol) than the OVX+CASEIN group, whereas OVX+SOY- was similar to OVX+CASEIN (mean +/- SD; SHAM, 1.522 +/- 0.041; OVX+CASEIN, 1.449 +/- 0.044; OVX+SOY, 1.497 +/- 0.030; OVX+SOY-, 1.452 +/- 0.030). Ovariectomy resulted in greater bone turnover as indicated by higher serum alkaline phosphatase activity, serum insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations, and urinary hydroxyproline. These increases were not affected by soy with either normal or reduced isoflavone content. Similarly, histomorphometry revealed a greater bone formation rate with ovariectomy, and this was not altered by the soy diets. The findings of this study suggest that isoflavones in soy protein are responsible for its bone-sparing effects. Further studies to evaluate the mechanism of action of isoflavones on bone are warranted. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/9848500/Bone_sparing_effect_of_soy_protein_in_ovarian_hormone_deficient_rats_is_related_to_its_isoflavone_content_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/68.6.1364S DB - PRIME DP - Unbound Medicine ER -