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Influence of soybean processing, habitual diet, and soy dose on urinary isoflavonoid excretion.
Am J Clin Nutr. 1998 12; 68(6 Suppl):1492S-1495S.AJ

Abstract

In an attempt to explain the wide individual variation seen in urinary isoflavonoid phytoestrogen excretion, we conducted a series of 3 human feeding studies: a large cross-sectional study of equol production in humans with a soy challenge, a comparison of phytoestrogen metabolism when subjects consumed fermented and unfermented soy products, and a dose-response study of urinary isoflavonoid excretion at the low end of soy consumption. All studies were conducted in young, healthy humans. Urinary isoflavonoids were measured by isotope-dilution gas chromatography-mass spectrometry. Similar to results from other studies, 35% of screened subjects (30 men and 30 women) excreted equol (>2000 nmol/d). In women, equol excretion was associated with higher intake of dietary fiber and carbohydrate. Fermentation of soy decreased the isoflavone content of the product fed but increased the urinary isoflavonoid recovery, suggesting that fermentation increases availability of isoflavones in soy. When soy-protein powder was fed at 0, 5, 10, and 20 g/d (0-36 mg isoflavones), there was a linear dose response of urinary isoflavonoid excretion to soy consumption that did not differ between subjects with high and low equol excretion. These results suggest that equol excretion may be related to the fermentable carbohydrate content of the diet; additional study is needed. Processing of soy affects isoflavone metabolism and must be considered in recommending exposure to isoflavones from soyfoods. Although optimal isoflavone exposure for disease protection has not been determined, urinary isoflavonoid excretion appears linear at low-to-moderate soy consumption.

Authors+Show Affiliations

Department of Food Science and Nutrition, University of Minnesota, St Paul 55108, USA. jslavin@che2.che.umn.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9848522

Citation

Slavin, J L., et al. "Influence of Soybean Processing, Habitual Diet, and Soy Dose On Urinary Isoflavonoid Excretion." The American Journal of Clinical Nutrition, vol. 68, no. 6 Suppl, 1998, 1492S-1495S.
Slavin JL, Karr SC, Hutchins AM, et al. Influence of soybean processing, habitual diet, and soy dose on urinary isoflavonoid excretion. Am J Clin Nutr. 1998;68(6 Suppl):1492S-1495S.
Slavin, J. L., Karr, S. C., Hutchins, A. M., & Lampe, J. W. (1998). Influence of soybean processing, habitual diet, and soy dose on urinary isoflavonoid excretion. The American Journal of Clinical Nutrition, 68(6 Suppl), 1492S-1495S. https://doi.org/10.1093/ajcn/68.6.1492S
Slavin JL, et al. Influence of Soybean Processing, Habitual Diet, and Soy Dose On Urinary Isoflavonoid Excretion. Am J Clin Nutr. 1998;68(6 Suppl):1492S-1495S. PubMed PMID: 9848522.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of soybean processing, habitual diet, and soy dose on urinary isoflavonoid excretion. AU - Slavin,J L, AU - Karr,S C, AU - Hutchins,A M, AU - Lampe,J W, PY - 1998/12/16/pubmed PY - 1998/12/16/medline PY - 1998/12/16/entrez SP - 1492S EP - 1495S JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 68 IS - 6 Suppl N2 - In an attempt to explain the wide individual variation seen in urinary isoflavonoid phytoestrogen excretion, we conducted a series of 3 human feeding studies: a large cross-sectional study of equol production in humans with a soy challenge, a comparison of phytoestrogen metabolism when subjects consumed fermented and unfermented soy products, and a dose-response study of urinary isoflavonoid excretion at the low end of soy consumption. All studies were conducted in young, healthy humans. Urinary isoflavonoids were measured by isotope-dilution gas chromatography-mass spectrometry. Similar to results from other studies, 35% of screened subjects (30 men and 30 women) excreted equol (>2000 nmol/d). In women, equol excretion was associated with higher intake of dietary fiber and carbohydrate. Fermentation of soy decreased the isoflavone content of the product fed but increased the urinary isoflavonoid recovery, suggesting that fermentation increases availability of isoflavones in soy. When soy-protein powder was fed at 0, 5, 10, and 20 g/d (0-36 mg isoflavones), there was a linear dose response of urinary isoflavonoid excretion to soy consumption that did not differ between subjects with high and low equol excretion. These results suggest that equol excretion may be related to the fermentable carbohydrate content of the diet; additional study is needed. Processing of soy affects isoflavone metabolism and must be considered in recommending exposure to isoflavones from soyfoods. Although optimal isoflavone exposure for disease protection has not been determined, urinary isoflavonoid excretion appears linear at low-to-moderate soy consumption. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/9848522/Influence_of_soybean_processing_habitual_diet_and_soy_dose_on_urinary_isoflavonoid_excretion_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/68.6.1492S DB - PRIME DP - Unbound Medicine ER -