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Efficacy and acceptability of two monophasic oral contraceptives containing ethinylestradiol and either desogestrel or gestodene.
Eur J Contracept Reprod Health Care. 1998 Sep; 3(3):113-20.EJ

Abstract

OBJECTIVE

To assess the contraceptive efficacy, cycle control and acceptability of two monophasic oral contraceptives containing either 30 micrograms ethinylestradiol plus 150 micrograms desogestrel or 30 micrograms ethinylestradiol plus 75 micrograms gestodene.

METHODS

In a randomized, open-label, six-cycle, group-comparative, multicenter study performed in Brazil, pregnancies, cycle-control parameters, incidence of side-effects and the presence and severity of acne vulgaris were assessed, and blood pressure and body weight were measured at pretreatment and after one, three and six cycles of oral contraceptive use.

RESULTS

Of the 595 women enrolled, 274 (86.7%) in the desogestrel/ethinylestradiol group and 227 (81.4%) in the gestodene/ethinylestradiol group completed the six cycles, providing data for 1753 and 1487 treatment cycles, respectively. Two pregnancies occurred, one of which (in the desogestrel/ethinylestradiol group) was attributed to user failure, whilst the other (in the gestodene/ethinylestradiol group) was thought to result from method failure. Cycle control was observed to be excellent; the incidences of irregular bleeding and minor side-effects were low in both groups and decreased after an initial increase in the first cycle. Pre-existing acne improved in both groups, whereas blood pressure and body weight remained essentially unchanged.

CONCLUSIONS

Both desogestrel/ethinylestradiol and gestodene/ethinylestradiol provide effective oral contraception with comparable cycle control and acceptability.

Authors+Show Affiliations

Department of Gynecology and Obstetrics of São Paulo University, Hospital das Clínicas, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9853201

Citation

Halbe, H W., et al. "Efficacy and Acceptability of Two Monophasic Oral Contraceptives Containing Ethinylestradiol and Either Desogestrel or Gestodene." The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception, vol. 3, no. 3, 1998, pp. 113-20.
Halbe HW, de Melo NR, Bahamondes L, et al. Efficacy and acceptability of two monophasic oral contraceptives containing ethinylestradiol and either desogestrel or gestodene. Eur J Contracept Reprod Health Care. 1998;3(3):113-20.
Halbe, H. W., de Melo, N. R., Bahamondes, L., Petracco, A., Lemgruber, M., de Andrade, R. P., da Cunha, D. C., Guazelli, C. A., & Baracat, E. C. (1998). Efficacy and acceptability of two monophasic oral contraceptives containing ethinylestradiol and either desogestrel or gestodene. The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception, 3(3), 113-20.
Halbe HW, et al. Efficacy and Acceptability of Two Monophasic Oral Contraceptives Containing Ethinylestradiol and Either Desogestrel or Gestodene. Eur J Contracept Reprod Health Care. 1998;3(3):113-20. PubMed PMID: 9853201.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy and acceptability of two monophasic oral contraceptives containing ethinylestradiol and either desogestrel or gestodene. AU - Halbe,H W, AU - de Melo,N R, AU - Bahamondes,L, AU - Petracco,A, AU - Lemgruber,M, AU - de Andrade,R P, AU - da Cunha,D C, AU - Guazelli,C A, AU - Baracat,E C, PY - 1998/12/16/pubmed PY - 1998/12/16/medline PY - 1998/12/16/entrez SP - 113 EP - 20 JF - The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception JO - Eur J Contracept Reprod Health Care VL - 3 IS - 3 N2 - OBJECTIVE: To assess the contraceptive efficacy, cycle control and acceptability of two monophasic oral contraceptives containing either 30 micrograms ethinylestradiol plus 150 micrograms desogestrel or 30 micrograms ethinylestradiol plus 75 micrograms gestodene. METHODS: In a randomized, open-label, six-cycle, group-comparative, multicenter study performed in Brazil, pregnancies, cycle-control parameters, incidence of side-effects and the presence and severity of acne vulgaris were assessed, and blood pressure and body weight were measured at pretreatment and after one, three and six cycles of oral contraceptive use. RESULTS: Of the 595 women enrolled, 274 (86.7%) in the desogestrel/ethinylestradiol group and 227 (81.4%) in the gestodene/ethinylestradiol group completed the six cycles, providing data for 1753 and 1487 treatment cycles, respectively. Two pregnancies occurred, one of which (in the desogestrel/ethinylestradiol group) was attributed to user failure, whilst the other (in the gestodene/ethinylestradiol group) was thought to result from method failure. Cycle control was observed to be excellent; the incidences of irregular bleeding and minor side-effects were low in both groups and decreased after an initial increase in the first cycle. Pre-existing acne improved in both groups, whereas blood pressure and body weight remained essentially unchanged. CONCLUSIONS: Both desogestrel/ethinylestradiol and gestodene/ethinylestradiol provide effective oral contraception with comparable cycle control and acceptability. SN - 1362-5187 UR - https://www.unboundmedicine.com/medline/citation/9853201/Efficacy_and_acceptability_of_two_monophasic_oral_contraceptives_containing_ethinylestradiol_and_either_desogestrel_or_gestodene_ L2 - http://www.tandfonline.com/doi/full/10.3109/13625189809051413 DB - PRIME DP - Unbound Medicine ER -