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Piper methysticum (kava kava).
Altern Med Rev. 1998 Dec; 3(6):458-60.AM

Abstract

Piper methysticum (kava kava) is a plant native to the Pacific Island region, and has been used ceremonial for thousands of years. The active ingredients are a group of substances know as kava lactones (AKA kava pyrones). Four lactones in kava have been found to have significant analgesic and anesthetic effects via non-opiate pathways. Kava's most popular application is as a natural anxiolytic, comparing favorably in several studies to a number prescription medications, including benzodiazepines. CNS effects seem to be mediated by several mechanisms. Studies have been conflicting regarding its GABA-receptor-binding capacity, although this has been found to occur in some studies. In vitro kava has been found to block norepinephrine uptake. It also has some anti-convulsant capabilities, which appear to be mediated by Na+ channel receptor sites. The therapeutic dosage is in the range of 50-70 mg kava lactones three times daily. The most common side effect, usually seen only with long-term, heavy usage of the herb, is a scaly skin rash called "kava dermopathy." It has also been know to potentiate other medications such as barbiturates and Xanax.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9855570

Citation

"Piper Methysticum (kava Kava)." Alternative Medicine Review : a Journal of Clinical Therapeutic, vol. 3, no. 6, 1998, pp. 458-60.
Piper methysticum (kava kava). Altern Med Rev. 1998;3(6):458-60.
(1998). Piper methysticum (kava kava). Alternative Medicine Review : a Journal of Clinical Therapeutic, 3(6), 458-60.
Piper Methysticum (kava Kava). Altern Med Rev. 1998;3(6):458-60. PubMed PMID: 9855570.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Piper methysticum (kava kava). PY - 1998/12/17/pubmed PY - 1998/12/17/medline PY - 1998/12/17/entrez SP - 458 EP - 60 JF - Alternative medicine review : a journal of clinical therapeutic JO - Altern Med Rev VL - 3 IS - 6 N2 - Piper methysticum (kava kava) is a plant native to the Pacific Island region, and has been used ceremonial for thousands of years. The active ingredients are a group of substances know as kava lactones (AKA kava pyrones). Four lactones in kava have been found to have significant analgesic and anesthetic effects via non-opiate pathways. Kava's most popular application is as a natural anxiolytic, comparing favorably in several studies to a number prescription medications, including benzodiazepines. CNS effects seem to be mediated by several mechanisms. Studies have been conflicting regarding its GABA-receptor-binding capacity, although this has been found to occur in some studies. In vitro kava has been found to block norepinephrine uptake. It also has some anti-convulsant capabilities, which appear to be mediated by Na+ channel receptor sites. The therapeutic dosage is in the range of 50-70 mg kava lactones three times daily. The most common side effect, usually seen only with long-term, heavy usage of the herb, is a scaly skin rash called "kava dermopathy." It has also been know to potentiate other medications such as barbiturates and Xanax. SN - 1089-5159 UR - https://www.unboundmedicine.com/medline/citation/9855570/Piper_methysticum__kava_kava__ L2 - http://archive.foundationalmedicinereview.com/publications/3/6/458.pdf DB - PRIME DP - Unbound Medicine ER -
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