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The TSH-dependent variation of the essential elements iodine, selenium and zinc within human thyroid tissues.

Abstract

Instrumental Neutron Activation Analysis was used in order to measure iodine, selenium and zinc concentration in thyroid samples. A pair of samples of normal and nodular tissue were collected from the thyroid gland from 72 patients selected on the basis of pathological criteria (44 cases of multinodular goiter, 12 of chronic lymphocytic thyroiditis (CLT), 6 of thyroid adenoma (TA) and 12 of thyroid cancer (TC)). The check for tissue homogeneity and sampling error was performed by means of the coefficient of variation (CV%) of the elements in replicate samples of normal and altered tissues. High CV% values (> 15%) for iodine reflected a functional variability in thyroid follicles, while low CV% values (< 10%) for selenium and zinc indicated that the composition of selected tissues was rather homogeneous. The variation of the element's concentration was compared in normal and altered tissues. The mean element concentrations had values close to those already reported in the literature; furthermore, our patients had marginal iodine and selenium deficiency. Both normal and nodular tissues in CLT showed statistically significant lower zinc values as compared with the other thyroid diseases. To evaluate the thyroid function, thyroid stimulating hormone (TSH) and thyroxine (T4) levels were measured in the serum of patients. Two arbitrary serum-TSH threshold levels (TSH < 1.0 and > 4.0 mU/L) were introduced in order to classify, respectively, hyperthyroidism and hypothyroidism, as well as euthyroid conditions (1.0 < TSH < 4.0 mU/L), and each patient was assigned to one of these groups. The influence of TSH in the variation of the concentration of iodine, selenium and zinc in normal and altered human thyroid tissues was significant.

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  • Authors+Show Affiliations

    ,

    Istituto di Immunologia e Malattie Infettive, Università di Verona, Policlinico Borgo Roma, Italy.

    , , , , , ,

    Source

    MeSH

    Adolescent
    Adult
    Aged
    Aged, 80 and over
    Female
    Humans
    Iodine
    Male
    Middle Aged
    Reference Values
    Selenium
    Thyroid Diseases
    Thyroid Gland
    Thyrotropin
    Zinc

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    9857330

    Citation

    Bellisola, G, et al. "The TSH-dependent Variation of the Essential Elements Iodine, Selenium and Zinc Within Human Thyroid Tissues." Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS), vol. 12, no. 3, 1998, pp. 177-82.
    Bellisola G, Brätter P, Cinque G, et al. The TSH-dependent variation of the essential elements iodine, selenium and zinc within human thyroid tissues. J Trace Elem Med Biol. 1998;12(3):177-82.
    Bellisola, G., Brätter, P., Cinque, G., Francia, G., Galassini, S., Gawlik, D., ... Azzolina, L. (1998). The TSH-dependent variation of the essential elements iodine, selenium and zinc within human thyroid tissues. Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS), 12(3), pp. 177-82.
    Bellisola G, et al. The TSH-dependent Variation of the Essential Elements Iodine, Selenium and Zinc Within Human Thyroid Tissues. J Trace Elem Med Biol. 1998;12(3):177-82. PubMed PMID: 9857330.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The TSH-dependent variation of the essential elements iodine, selenium and zinc within human thyroid tissues. AU - Bellisola,G, AU - Brätter,P, AU - Cinque,G, AU - Francia,G, AU - Galassini,S, AU - Gawlik,D, AU - Negretti de Brätter,V E, AU - Azzolina,L, PY - 1998/12/19/pubmed PY - 1998/12/19/medline PY - 1998/12/19/entrez SP - 177 EP - 82 JF - Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) JO - J Trace Elem Med Biol VL - 12 IS - 3 N2 - Instrumental Neutron Activation Analysis was used in order to measure iodine, selenium and zinc concentration in thyroid samples. A pair of samples of normal and nodular tissue were collected from the thyroid gland from 72 patients selected on the basis of pathological criteria (44 cases of multinodular goiter, 12 of chronic lymphocytic thyroiditis (CLT), 6 of thyroid adenoma (TA) and 12 of thyroid cancer (TC)). The check for tissue homogeneity and sampling error was performed by means of the coefficient of variation (CV%) of the elements in replicate samples of normal and altered tissues. High CV% values (> 15%) for iodine reflected a functional variability in thyroid follicles, while low CV% values (< 10%) for selenium and zinc indicated that the composition of selected tissues was rather homogeneous. The variation of the element's concentration was compared in normal and altered tissues. The mean element concentrations had values close to those already reported in the literature; furthermore, our patients had marginal iodine and selenium deficiency. Both normal and nodular tissues in CLT showed statistically significant lower zinc values as compared with the other thyroid diseases. To evaluate the thyroid function, thyroid stimulating hormone (TSH) and thyroxine (T4) levels were measured in the serum of patients. Two arbitrary serum-TSH threshold levels (TSH < 1.0 and > 4.0 mU/L) were introduced in order to classify, respectively, hyperthyroidism and hypothyroidism, as well as euthyroid conditions (1.0 < TSH < 4.0 mU/L), and each patient was assigned to one of these groups. The influence of TSH in the variation of the concentration of iodine, selenium and zinc in normal and altered human thyroid tissues was significant. SN - 0946-672X UR - https://www.unboundmedicine.com/medline/citation/9857330/The_TSH_dependent_variation_of_the_essential_elements_iodine_selenium_and_zinc_within_human_thyroid_tissues_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0946-672X(98)80006-0 DB - PRIME DP - Unbound Medicine ER -