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[Results of examination in healthy volunteers of rifampicin and isoniazid bioavailability from Polish two-drug combination capsules of rifamazid used for tuberculosis treatment].
Pneumonol Alergol Pol. 1998; 66(3-4):198-206.PA

Abstract

Purpose of the study was the examination of the relative bioavailability of rifampicin and isoniazid from Rifamazid (fixed-dose combination) and bioavailability of each drug in free simultaneous combination. The study was carried out as an open randomized cross-over study comprising 16 healthy volunteers for study of rifampicin and 15 healthy volunteers (slow acetylators) for isoniazid. The results have shown, that the pattern of absorption, elimination, plasma concentrations and pharmacokinetics parameters were found similar after administration of the drugs in free and in fixed combination.

Authors+Show Affiliations

Zakładu Mikrobiologii, Instytutu Gruźlicy i Chorób Pluc w Warszawie.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
English Abstract
Journal Article
Randomized Controlled Trial

Language

pol

PubMed ID

9857665

Citation

Zofia, Z, et al. "[Results of Examination in Healthy Volunteers of Rifampicin and Isoniazid Bioavailability From Polish Two-drug Combination Capsules of Rifamazid Used for Tuberculosis Treatment]." Pneumonologia I Alergologia Polska, vol. 66, no. 3-4, 1998, pp. 198-206.
Zofia Z, Niemirowska-Mikulska H, Augustynowicz-Kopeć E, et al. [Results of examination in healthy volunteers of rifampicin and isoniazid bioavailability from Polish two-drug combination capsules of rifamazid used for tuberculosis treatment]. Pneumonol Alergol Pol. 1998;66(3-4):198-206.
Zofia, Z., Niemirowska-Mikulska, H., Augustynowicz-Kopeć, E., & Stambrowska, A. (1998). [Results of examination in healthy volunteers of rifampicin and isoniazid bioavailability from Polish two-drug combination capsules of rifamazid used for tuberculosis treatment]. Pneumonologia I Alergologia Polska, 66(3-4), 198-206.
Zofia Z, et al. [Results of Examination in Healthy Volunteers of Rifampicin and Isoniazid Bioavailability From Polish Two-drug Combination Capsules of Rifamazid Used for Tuberculosis Treatment]. Pneumonol Alergol Pol. 1998;66(3-4):198-206. PubMed PMID: 9857665.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Results of examination in healthy volunteers of rifampicin and isoniazid bioavailability from Polish two-drug combination capsules of rifamazid used for tuberculosis treatment]. AU - Zofia,Z, AU - Niemirowska-Mikulska,H, AU - Augustynowicz-Kopeć,E, AU - Stambrowska,A, PY - 1998/12/19/pubmed PY - 1998/12/19/medline PY - 1998/12/19/entrez SP - 198 EP - 206 JF - Pneumonologia i alergologia polska JO - Pneumonol Alergol Pol VL - 66 IS - 3-4 N2 - Purpose of the study was the examination of the relative bioavailability of rifampicin and isoniazid from Rifamazid (fixed-dose combination) and bioavailability of each drug in free simultaneous combination. The study was carried out as an open randomized cross-over study comprising 16 healthy volunteers for study of rifampicin and 15 healthy volunteers (slow acetylators) for isoniazid. The results have shown, that the pattern of absorption, elimination, plasma concentrations and pharmacokinetics parameters were found similar after administration of the drugs in free and in fixed combination. SN - 0867-7077 UR - https://www.unboundmedicine.com/medline/citation/9857665/[Results_of_examination_in_healthy_volunteers_of_rifampicin_and_isoniazid_bioavailability_from_Polish_two_drug_combination_capsules_of_rifamazid_used_for_tuberculosis_treatment]_ L2 - http://www.diseaseinfosearch.org/result/7252 DB - PRIME DP - Unbound Medicine ER -