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[Zinc deficiency in liver cirrhosis: a curiosity or a problem?].

Abstract

This article reviews the literature on the role of zinc in liver cirrhosis and dietary zinc supplementation for cirrhotic patients with hepatic encephalopathy. Zinc is a trace metal found in many proteins and enzymes having catalytical, cocatalytical and structural functions. Zinc deficiency has been demonstrated in cirrhotic patients, and dietary supplementation of this metal could benefit the urea cycle, glucose and protein metabolism, and central nervous system neurotransmission in these subjects. After some brief considerations on normal zinc metabolism, the role zinc plays in the central nervous system, and its conduct in patients with hepatic encephalopathy, possible links between zinc deficiency and the pathophysiology of central nervous system dysfunction in cirrhotic patients are discussed. The article concludes with a critical review of favorable and unfavorable evidence for zinc supplementation in patients with hepatic encephalopathy.

Authors+Show Affiliations

,

Università degli Studi di Padova.

, ,

Source

MeSH

Central Nervous System
Hepatic Encephalopathy
Humans
Liver Cirrhosis
Zinc

Pub Type(s)

English Abstract
Journal Article
Review

Language

ita

PubMed ID

9859572

Citation

Marchetti, P, et al. "[Zinc Deficiency in Liver Cirrhosis: a Curiosity or a Problem?]." Annali Italiani Di Medicina Interna : Organo Ufficiale Della Societa Italiana Di Medicina Interna, vol. 13, no. 3, 1998, pp. 157-62.
Marchetti P, Amodio P, Caregaro L, et al. [Zinc deficiency in liver cirrhosis: a curiosity or a problem?]. Ann Ital Med Int. 1998;13(3):157-62.
Marchetti, P., Amodio, P., Caregaro, L., & Gatta, A. (1998). [Zinc deficiency in liver cirrhosis: a curiosity or a problem?]. Annali Italiani Di Medicina Interna : Organo Ufficiale Della Societa Italiana Di Medicina Interna, 13(3), pp. 157-62.
Marchetti P, et al. [Zinc Deficiency in Liver Cirrhosis: a Curiosity or a Problem?]. Ann Ital Med Int. 1998;13(3):157-62. PubMed PMID: 9859572.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Zinc deficiency in liver cirrhosis: a curiosity or a problem?]. AU - Marchetti,P, AU - Amodio,P, AU - Caregaro,L, AU - Gatta,A, PY - 1998/12/22/pubmed PY - 1998/12/22/medline PY - 1998/12/22/entrez SP - 157 EP - 62 JF - Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna JO - Ann. Ital. Med. Int. VL - 13 IS - 3 N2 - This article reviews the literature on the role of zinc in liver cirrhosis and dietary zinc supplementation for cirrhotic patients with hepatic encephalopathy. Zinc is a trace metal found in many proteins and enzymes having catalytical, cocatalytical and structural functions. Zinc deficiency has been demonstrated in cirrhotic patients, and dietary supplementation of this metal could benefit the urea cycle, glucose and protein metabolism, and central nervous system neurotransmission in these subjects. After some brief considerations on normal zinc metabolism, the role zinc plays in the central nervous system, and its conduct in patients with hepatic encephalopathy, possible links between zinc deficiency and the pathophysiology of central nervous system dysfunction in cirrhotic patients are discussed. The article concludes with a critical review of favorable and unfavorable evidence for zinc supplementation in patients with hepatic encephalopathy. SN - 0393-9340 UR - https://www.unboundmedicine.com/medline/citation/9859572/[Zinc_deficiency_in_liver_cirrhosis:_a_curiosity_or_a_problem]_ L2 - https://medlineplus.gov/cirrhosis.html DB - PRIME DP - Unbound Medicine ER -