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[Blockade of (+/-) 12-chloroscoulerine on feed-back regulation of dopamine D2 autoreceptors].
Zhongguo Yao Li Xue Bao. 1996 Sep; 17(5):477-80.ZY

Abstract

AIM

To verify whether (+/-) 12-chloroscoulerine (CSL) is antagonist or agonist effect to D2 autoreceptors.

METHODS

The levodopa content accumulated in the rat striatum was measured by HPLC-ECD, and the DA neuron firing activity in the substantia nigra zona compacta (SNC) was recorded.

RESULTS

The accumulated levodopa content induced by CSL 40 mg.kg-1 was much more than that of 1,4-butyro-lactone (BL) group (P < 0.01). After i.p. injection of apomorphine (Apo) 5 mg.kg-1, the levodopa content was decreased below that of BL group (P < 0.05). The Apo inhibition on levodopa content was completely reversed by CSL (40 mg.kg-1, i.p.) and then increased the levodopa content (2.5 +/- 1.1 micrograms.g-1) over that of Apo group (0.7 +/- 0.3 microgram.g-1, P < 0.01). In the electrophysiologic recording, Apo (15 micrograms.kg-1, i.v.) induced the decrease of SNC DA cell firing rate nearly to zero. At the accumulated dose of CSL up to 80 micrograms.kg-1 (i.v.), the inhibition of Apo was attenuated and the firing activity was restored to predrug level.

CONCLUSION

CSL showed an antagonistic action, an action to D2 autoreceptors.

Authors+Show Affiliations

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

9863180

Citation

Chen, L J., et al. "[Blockade of (+/-) 12-chloroscoulerine On Feed-back Regulation of Dopamine D2 Autoreceptors]." Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica, vol. 17, no. 5, 1996, pp. 477-80.
Chen LJ, Zhang XX, Guo X. [Blockade of (+/-) 12-chloroscoulerine on feed-back regulation of dopamine D2 autoreceptors]. Zhongguo Yao Li Xue Bao. 1996;17(5):477-80.
Chen, L. J., Zhang, X. X., & Guo, X. (1996). [Blockade of (+/-) 12-chloroscoulerine on feed-back regulation of dopamine D2 autoreceptors]. Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica, 17(5), 477-80.
Chen LJ, Zhang XX, Guo X. [Blockade of (+/-) 12-chloroscoulerine On Feed-back Regulation of Dopamine D2 Autoreceptors]. Zhongguo Yao Li Xue Bao. 1996;17(5):477-80. PubMed PMID: 9863180.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Blockade of (+/-) 12-chloroscoulerine on feed-back regulation of dopamine D2 autoreceptors]. AU - Chen,L J, AU - Zhang,X X, AU - Guo,X, PY - 1996/9/1/pubmed PY - 1998/12/24/medline PY - 1996/9/1/entrez SP - 477 EP - 80 JF - Zhongguo yao li xue bao = Acta pharmacologica Sinica JO - Zhongguo Yao Li Xue Bao VL - 17 IS - 5 N2 - AIM: To verify whether (+/-) 12-chloroscoulerine (CSL) is antagonist or agonist effect to D2 autoreceptors. METHODS: The levodopa content accumulated in the rat striatum was measured by HPLC-ECD, and the DA neuron firing activity in the substantia nigra zona compacta (SNC) was recorded. RESULTS: The accumulated levodopa content induced by CSL 40 mg.kg-1 was much more than that of 1,4-butyro-lactone (BL) group (P < 0.01). After i.p. injection of apomorphine (Apo) 5 mg.kg-1, the levodopa content was decreased below that of BL group (P < 0.05). The Apo inhibition on levodopa content was completely reversed by CSL (40 mg.kg-1, i.p.) and then increased the levodopa content (2.5 +/- 1.1 micrograms.g-1) over that of Apo group (0.7 +/- 0.3 microgram.g-1, P < 0.01). In the electrophysiologic recording, Apo (15 micrograms.kg-1, i.v.) induced the decrease of SNC DA cell firing rate nearly to zero. At the accumulated dose of CSL up to 80 micrograms.kg-1 (i.v.), the inhibition of Apo was attenuated and the firing activity was restored to predrug level. CONCLUSION: CSL showed an antagonistic action, an action to D2 autoreceptors. SN - 0253-9756 UR - https://www.unboundmedicine.com/medline/citation/9863180/[Blockade_of__+/___12_chloroscoulerine_on_feed_back_regulation_of_dopamine_D2_autoreceptors]_ L2 - http://www.chinaphar.com/1671-4083/17/477.pdf DB - PRIME DP - Unbound Medicine ER -