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The role of serum transferrin receptor in the diagnosis of iron deficiency.
Haematologica. 1998 Nov; 83(11):963-6.H

Abstract

BACKGROUND AND OBJECTIVE

Iron deficiency anemia (IDA) is often associated with inflammatory disorders. The most conventional parameters of iron metabolism are therefore affected, making the evaluation of iron status difficult. Serum transferrin receptor (sTfR) levels are raised in iron deficiency but are not influenced by inflammatory changes. The aim of this study was to investigate the role of sTfR in differentiating IDA with inflammatory features.

DESIGN AND METHODS

A diagnostic study of sTfR measured by immunoassay was carried out in IDA and anemia of chronic disorders (ACD). The cut-off points of sTfR and the ratio of sTfR/serum ferritin, which were obtained after comparing IDA and ACD, were applied to a group of 64 patients with mixed iron patterns (MIX) (16 with ACD and 48 with IDA).

RESULTS

The best cut-off point of sTfR between IDA and ACD was 4.7 mg/L. Applying this cut-off to the MIX group, an efficiency of 87% was obtained (sensitivity 92% and specificity 81%). This level of sTfR correctly classified 53 out of 64 cases of the MIX group (83%). Using the ratio of sTfRx 100/serum ferritin, the best cut-off point was 8 (efficiency 100%), which correctly classified 62 out of 64 cases of the MIX group (97%).

INTERPRETATION AND CONCLUSIONS

This study demonstrates that sTfR in conjunction with other iron parameters is very useful in iron deficiency evaluation, especially in hospital practice. Iron treatment should be considered in patients with mixed patterns of iron status, in which the diagnosis of IDA versus ACD is difficult, when the levels of sTfR exceed the cut-off point.

Authors+Show Affiliations

Department of Hematology, Hospital de Sant Pau, Barcelona, Spain. aremachas@aehh.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

9864913

Citation

Remacha, A F., et al. "The Role of Serum Transferrin Receptor in the Diagnosis of Iron Deficiency." Haematologica, vol. 83, no. 11, 1998, pp. 963-6.
Remacha AF, Sarda MP, Parellada M, et al. The role of serum transferrin receptor in the diagnosis of iron deficiency. Haematologica. 1998;83(11):963-6.
Remacha, A. F., Sarda, M. P., Parellada, M., Ubeda, J., & Manteiga, R. (1998). The role of serum transferrin receptor in the diagnosis of iron deficiency. Haematologica, 83(11), 963-6.
Remacha AF, et al. The Role of Serum Transferrin Receptor in the Diagnosis of Iron Deficiency. Haematologica. 1998;83(11):963-6. PubMed PMID: 9864913.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of serum transferrin receptor in the diagnosis of iron deficiency. AU - Remacha,A F, AU - Sarda,M P, AU - Parellada,M, AU - Ubeda,J, AU - Manteiga,R, PY - 1998/12/29/pubmed PY - 1998/12/29/medline PY - 1998/12/29/entrez SP - 963 EP - 6 JF - Haematologica JO - Haematologica VL - 83 IS - 11 N2 - BACKGROUND AND OBJECTIVE: Iron deficiency anemia (IDA) is often associated with inflammatory disorders. The most conventional parameters of iron metabolism are therefore affected, making the evaluation of iron status difficult. Serum transferrin receptor (sTfR) levels are raised in iron deficiency but are not influenced by inflammatory changes. The aim of this study was to investigate the role of sTfR in differentiating IDA with inflammatory features. DESIGN AND METHODS: A diagnostic study of sTfR measured by immunoassay was carried out in IDA and anemia of chronic disorders (ACD). The cut-off points of sTfR and the ratio of sTfR/serum ferritin, which were obtained after comparing IDA and ACD, were applied to a group of 64 patients with mixed iron patterns (MIX) (16 with ACD and 48 with IDA). RESULTS: The best cut-off point of sTfR between IDA and ACD was 4.7 mg/L. Applying this cut-off to the MIX group, an efficiency of 87% was obtained (sensitivity 92% and specificity 81%). This level of sTfR correctly classified 53 out of 64 cases of the MIX group (83%). Using the ratio of sTfRx 100/serum ferritin, the best cut-off point was 8 (efficiency 100%), which correctly classified 62 out of 64 cases of the MIX group (97%). INTERPRETATION AND CONCLUSIONS: This study demonstrates that sTfR in conjunction with other iron parameters is very useful in iron deficiency evaluation, especially in hospital practice. Iron treatment should be considered in patients with mixed patterns of iron status, in which the diagnosis of IDA versus ACD is difficult, when the levels of sTfR exceed the cut-off point. SN - 0390-6078 UR - https://www.unboundmedicine.com/medline/citation/9864913/The_role_of_serum_transferrin_receptor_in_the_diagnosis_of_iron_deficiency_ L2 - http://www.haematologica.org/cgi/pmidlookup?view=long&pmid=9864913 DB - PRIME DP - Unbound Medicine ER -