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Pretreatment with an oral contraceptive is effective in reducing the incidence of functional ovarian cyst formation during pituitary suppression by gonadotropin-releasing hormone analogues.
J Assist Reprod Genet. 1998 Nov; 15(10):599-604.JA

Abstract

PURPOSE

Our purpose was to assess the effect of pretreatment with oral contraceptives (OCs) on the formation of functional ovarian cysts during pituitary suppression with gonadotropin-releasing hormone (GnRH) agonists, subsequent follicular development, and pregnancy rates.

METHODS

A retrospective case-controlled study of 31 in vitro fertilization (IVF) patients, all of whom in a previous cycle had commenced the long protocol of GnRH-agonist (Buserelin) in the early follicular phase and were pretreated in a subsequent cycle with 2 weeks of an OC containing 30 micrograms of ethinyl estradiol and 150 micrograms of desogestrel prior to GnRH-agonist administration, was undertaken. Follow-up visits were arranged after a minimum of 11 days of GnRH-agonist administration and weekly thereafter until pituitary suppression was achieved.

RESULTS

Cysts were detected in 16 (51.6%) of the 31 patients not pretreated with OCs, and in 0 (0%) of the 31 patients pretreated with OCs (odds ratio = 67.1; 95% confidence interval = 5.6-350.7). Patients pretreated with OCs achieved pituitary suppression more rapidly (median difference = 4 days; 95% confidence interval = 2-7) and had comparable gonadotropin requirements and pregnancy rates.

CONCLUSIONS

Pretreatment with OCs prior to pituitary suppression in the early follicular phase decreases ovarian cyst formation, without an apparent effect on subsequent follicular recruitment or pregnancy rates.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Royal Victoria Hospital, Montreal, Quebec, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

9866068

Citation

Biljan, M M., et al. "Pretreatment With an Oral Contraceptive Is Effective in Reducing the Incidence of Functional Ovarian Cyst Formation During Pituitary Suppression By Gonadotropin-releasing Hormone Analogues." Journal of Assisted Reproduction and Genetics, vol. 15, no. 10, 1998, pp. 599-604.
Biljan MM, Mahutte NG, Dean N, et al. Pretreatment with an oral contraceptive is effective in reducing the incidence of functional ovarian cyst formation during pituitary suppression by gonadotropin-releasing hormone analogues. J Assist Reprod Genet. 1998;15(10):599-604.
Biljan, M. M., Mahutte, N. G., Dean, N., Hemmings, R., Bissonnette, F., & Tan, S. L. (1998). Pretreatment with an oral contraceptive is effective in reducing the incidence of functional ovarian cyst formation during pituitary suppression by gonadotropin-releasing hormone analogues. Journal of Assisted Reproduction and Genetics, 15(10), 599-604.
Biljan MM, et al. Pretreatment With an Oral Contraceptive Is Effective in Reducing the Incidence of Functional Ovarian Cyst Formation During Pituitary Suppression By Gonadotropin-releasing Hormone Analogues. J Assist Reprod Genet. 1998;15(10):599-604. PubMed PMID: 9866068.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pretreatment with an oral contraceptive is effective in reducing the incidence of functional ovarian cyst formation during pituitary suppression by gonadotropin-releasing hormone analogues. AU - Biljan,M M, AU - Mahutte,N G, AU - Dean,N, AU - Hemmings,R, AU - Bissonnette,F, AU - Tan,S L, PY - 1998/12/29/pubmed PY - 1998/12/29/medline PY - 1998/12/29/entrez KW - Americas KW - Biology KW - Canada KW - Case Control Studies KW - Contraception KW - Contraceptive Methods KW - Demographic Factors KW - Developed Countries KW - Diseases KW - Endocrine System KW - Family Planning KW - Fertility KW - Fertility Measurements KW - Gonadotropins KW - Gonadotropins, Pituitary KW - Hormones KW - North America KW - Northern America KW - Oral Contraceptives KW - Ovarian Cysts KW - Physiology KW - Population KW - Population Dynamics KW - Pregnancy Rate KW - Research Methodology KW - Research Report KW - Retrospective Studies KW - Studies SP - 599 EP - 604 JF - Journal of assisted reproduction and genetics JO - J Assist Reprod Genet VL - 15 IS - 10 N2 - PURPOSE: Our purpose was to assess the effect of pretreatment with oral contraceptives (OCs) on the formation of functional ovarian cysts during pituitary suppression with gonadotropin-releasing hormone (GnRH) agonists, subsequent follicular development, and pregnancy rates. METHODS: A retrospective case-controlled study of 31 in vitro fertilization (IVF) patients, all of whom in a previous cycle had commenced the long protocol of GnRH-agonist (Buserelin) in the early follicular phase and were pretreated in a subsequent cycle with 2 weeks of an OC containing 30 micrograms of ethinyl estradiol and 150 micrograms of desogestrel prior to GnRH-agonist administration, was undertaken. Follow-up visits were arranged after a minimum of 11 days of GnRH-agonist administration and weekly thereafter until pituitary suppression was achieved. RESULTS: Cysts were detected in 16 (51.6%) of the 31 patients not pretreated with OCs, and in 0 (0%) of the 31 patients pretreated with OCs (odds ratio = 67.1; 95% confidence interval = 5.6-350.7). Patients pretreated with OCs achieved pituitary suppression more rapidly (median difference = 4 days; 95% confidence interval = 2-7) and had comparable gonadotropin requirements and pregnancy rates. CONCLUSIONS: Pretreatment with OCs prior to pituitary suppression in the early follicular phase decreases ovarian cyst formation, without an apparent effect on subsequent follicular recruitment or pregnancy rates. SN - 1058-0468 UR - https://www.unboundmedicine.com/medline/citation/9866068/Pretreatment_with_an_oral_contraceptive_is_effective_in_reducing_the_incidence_of_functional_ovarian_cyst_formation_during_pituitary_suppression_by_gonadotropin_releasing_hormone_analogues_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=9866068.ui DB - PRIME DP - Unbound Medicine ER -