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[Macrocytic anemia with anisocytosis due to alcohol abuse and vitamin B6 deficiency].
Rinsho Ketsueki. 1998 Nov; 39(11):1127-30.RK

Abstract

Megaloblastic anemia due to folic acid deficiency and ringed sideroblastic anemia have been reported in alcohol abusers. It has also been reported that vitamin B6 deficiency causes ringed sideroblastic anemia as well as microcytic anemia that is not associated with ringed sideroblasts. We encountered a case of macrocytic anemia with anisocytosis in a 75-year-old alcohol abuser who suffered vitamin B6 deficiency. Neither megaloblastic changes nor ringed sideroblasts were observed in specimens of the patient's bone marrow. Analyses of porphyrin content and heme biosynthetic enzyme activity suggested a decline in ALA-synthase activity (an enzyme that depends on vitamin B6) as well as decreased ferrochelatase activity or abnormal iron metabolism. Abstention from alcohol led to a reduction in mean corpuscular volume and the disappearance of Pappenheimer bodies commonly observed in the red blood cells of drinkers. Follow-up supplements of vitamin B6 resolved the patient's anisocytosis and anemia.

Authors+Show Affiliations

First Department of Internal Medicine, Tokyo Medical College.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

jpn

PubMed ID

9866426

Citation

Iwama, H, et al. "[Macrocytic Anemia With Anisocytosis Due to Alcohol Abuse and Vitamin B6 Deficiency]." [Rinsho Ketsueki] the Japanese Journal of Clinical Hematology, vol. 39, no. 11, 1998, pp. 1127-30.
Iwama H, Iwase O, Hayashi S, et al. [Macrocytic anemia with anisocytosis due to alcohol abuse and vitamin B6 deficiency]. Rinsho Ketsueki. 1998;39(11):1127-30.
Iwama, H., Iwase, O., Hayashi, S., Nakano, M., & Toyama, K. (1998). [Macrocytic anemia with anisocytosis due to alcohol abuse and vitamin B6 deficiency]. [Rinsho Ketsueki] the Japanese Journal of Clinical Hematology, 39(11), 1127-30.
Iwama H, et al. [Macrocytic Anemia With Anisocytosis Due to Alcohol Abuse and Vitamin B6 Deficiency]. Rinsho Ketsueki. 1998;39(11):1127-30. PubMed PMID: 9866426.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Macrocytic anemia with anisocytosis due to alcohol abuse and vitamin B6 deficiency]. AU - Iwama,H, AU - Iwase,O, AU - Hayashi,S, AU - Nakano,M, AU - Toyama,K, PY - 1998/12/29/pubmed PY - 1998/12/29/medline PY - 1998/12/29/entrez SP - 1127 EP - 30 JF - [Rinsho ketsueki] The Japanese journal of clinical hematology JO - Rinsho Ketsueki VL - 39 IS - 11 N2 - Megaloblastic anemia due to folic acid deficiency and ringed sideroblastic anemia have been reported in alcohol abusers. It has also been reported that vitamin B6 deficiency causes ringed sideroblastic anemia as well as microcytic anemia that is not associated with ringed sideroblasts. We encountered a case of macrocytic anemia with anisocytosis in a 75-year-old alcohol abuser who suffered vitamin B6 deficiency. Neither megaloblastic changes nor ringed sideroblasts were observed in specimens of the patient's bone marrow. Analyses of porphyrin content and heme biosynthetic enzyme activity suggested a decline in ALA-synthase activity (an enzyme that depends on vitamin B6) as well as decreased ferrochelatase activity or abnormal iron metabolism. Abstention from alcohol led to a reduction in mean corpuscular volume and the disappearance of Pappenheimer bodies commonly observed in the red blood cells of drinkers. Follow-up supplements of vitamin B6 resolved the patient's anisocytosis and anemia. SN - 0485-1439 UR - https://www.unboundmedicine.com/medline/citation/9866426/[Macrocytic_anemia_with_anisocytosis_due_to_alcohol_abuse_and_vitamin_B6_deficiency]_ L2 - http://www.diseaseinfosearch.org/result/441 DB - PRIME DP - Unbound Medicine ER -