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Cycloartane triterpene glycosides from the roots of Astragalus brachypterus and Astragalus microcephalus.
J Nat Prod. 1998 Dec; 61(12):1469-72.JN

Abstract

Three new cycloartane-type triterpene glycosides, brachyosides A (1), B (3), and C (2), from the roots of Astragalus brachypterus and one new glycoside, cyclocephaloside II (4), from the roots of Astragalusmicrocephalus have been isolated together with five known saponins, astragalosides I, II, and IV, cyclocanthoside E, and cycloastragenol. The structures of the new compounds were established as 3-O-[beta-D-xylopyranosyl(1-->3)-beta-D-xylopyranosyl-6-O-beta-D-gluc opyranosyl-3beta,6alpha,16beta,24(S),25-pentahydrox ycycloartane (1), 3-O-beta-D-xylopyranosyl-6-O-beta-D-glucopyranosyl-24-O-beta-D-glucop yranosyl-3beta,6alpha,16beta,24(S),25-pentahydroxyc ycloartane (2), 20(R),24(S)-epoxy-6-O-beta-D-glucopyranosyl-3beta,6alpha,16beta , 25-tetrahydroxycycloartane (3), and 20(R), 24(S)-epoxy-3-O-(4'-O-acetyl)-beta-D-xylopyranosyl-6-O-beta-D-glucopy ranosyl-3beta,6alpha,16beta,25-tetrahydroxycycloart ane (4). For the structure elucidations, 1D- and 2D-NMR experiments and FABMS were used.

Authors+Show Affiliations

Department of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, TR-06100 Ankara, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9868145

Citation

Bedir, E, et al. "Cycloartane Triterpene Glycosides From the Roots of Astragalus Brachypterus and Astragalus Microcephalus." Journal of Natural Products, vol. 61, no. 12, 1998, pp. 1469-72.
Bedir E, Calis I, Aquino R, et al. Cycloartane triterpene glycosides from the roots of Astragalus brachypterus and Astragalus microcephalus. J Nat Prod. 1998;61(12):1469-72.
Bedir, E., Calis, I., Aquino, R., Piacente, S., & Pizza, C. (1998). Cycloartane triterpene glycosides from the roots of Astragalus brachypterus and Astragalus microcephalus. Journal of Natural Products, 61(12), 1469-72.
Bedir E, et al. Cycloartane Triterpene Glycosides From the Roots of Astragalus Brachypterus and Astragalus Microcephalus. J Nat Prod. 1998;61(12):1469-72. PubMed PMID: 9868145.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cycloartane triterpene glycosides from the roots of Astragalus brachypterus and Astragalus microcephalus. AU - Bedir,E, AU - Calis,I, AU - Aquino,R, AU - Piacente,S, AU - Pizza,C, PY - 1998/12/30/pubmed PY - 1998/12/30/medline PY - 1998/12/30/entrez SP - 1469 EP - 72 JF - Journal of natural products JO - J Nat Prod VL - 61 IS - 12 N2 - Three new cycloartane-type triterpene glycosides, brachyosides A (1), B (3), and C (2), from the roots of Astragalus brachypterus and one new glycoside, cyclocephaloside II (4), from the roots of Astragalusmicrocephalus have been isolated together with five known saponins, astragalosides I, II, and IV, cyclocanthoside E, and cycloastragenol. The structures of the new compounds were established as 3-O-[beta-D-xylopyranosyl(1-->3)-beta-D-xylopyranosyl-6-O-beta-D-gluc opyranosyl-3beta,6alpha,16beta,24(S),25-pentahydrox ycycloartane (1), 3-O-beta-D-xylopyranosyl-6-O-beta-D-glucopyranosyl-24-O-beta-D-glucop yranosyl-3beta,6alpha,16beta,24(S),25-pentahydroxyc ycloartane (2), 20(R),24(S)-epoxy-6-O-beta-D-glucopyranosyl-3beta,6alpha,16beta , 25-tetrahydroxycycloartane (3), and 20(R), 24(S)-epoxy-3-O-(4'-O-acetyl)-beta-D-xylopyranosyl-6-O-beta-D-glucopy ranosyl-3beta,6alpha,16beta,25-tetrahydroxycycloart ane (4). For the structure elucidations, 1D- and 2D-NMR experiments and FABMS were used. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/9868145/Cycloartane_triterpene_glycosides_from_the_roots_of_Astragalus_brachypterus_and_Astragalus_microcephalus_ L2 - https://doi.org/10.1021/np9801763 DB - PRIME DP - Unbound Medicine ER -