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Apolipoprotein E genotype is a determinant of low-density lipoprotein cholesterol and of its response to a low-cholesterol diet in Type 1 diabetic patients with elevated urinary albumin excretion.
Diabet Med. 1998 Dec; 15(12):1031-5.DM

Abstract

The effect of the apolipoprotein (apo) E genotype on the lipoprotein response to a 1 year low cholesterol diet (200 mg cholesterol per day) was evaluated in 36 patients with Type 1 diabetes mellitus with albuminuria between 10 and 200 microg min(-1). Apo E genotype was characterized by polymerase chain reaction and restriction isotyping. In 11 IDDM patients with at least one epsilon4 allele (apo E4 group), baseline serum total and low density lipoprotein (LDL) cholesterol were higher (p < 0.05 for both) than in 25 patients without an epsilon4 allele and with at least one epsilon3 allele (apo E3 group). Dietary counselling resulted in a similar decrease in cholesterol intake in both groups, whereas linoleic acid did not change. In the apo E4 group, serum total and LDL cholesterol at follow-up fell (p < 0.01 for both) to levels that were not different from those in the apo E3 group, and the changes in these parameters were greater (p < 0.02) than those in the apo E3 group. We conclude that the apo E4 allele is associated with atherogenic lipoprotein abnormalities in Type 1 DM patients with minor elevations in albuminuria when they use their habitual diet. Apo E4 carrying patients respond better to a low cholesterol diet.

Authors+Show Affiliations

Department of Endocrinology, University Hospital Groningen, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9868977

Citation

Blaauwwiekel, E E., et al. "Apolipoprotein E Genotype Is a Determinant of Low-density Lipoprotein Cholesterol and of Its Response to a Low-cholesterol Diet in Type 1 Diabetic Patients With Elevated Urinary Albumin Excretion." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 15, no. 12, 1998, pp. 1031-5.
Blaauwwiekel EE, Beusekamp BJ, Sluiter WJ, et al. Apolipoprotein E genotype is a determinant of low-density lipoprotein cholesterol and of its response to a low-cholesterol diet in Type 1 diabetic patients with elevated urinary albumin excretion. Diabet Med. 1998;15(12):1031-5.
Blaauwwiekel, E. E., Beusekamp, B. J., Sluiter, W. J., Hoogenberg, K., & Dullaart, R. P. (1998). Apolipoprotein E genotype is a determinant of low-density lipoprotein cholesterol and of its response to a low-cholesterol diet in Type 1 diabetic patients with elevated urinary albumin excretion. Diabetic Medicine : a Journal of the British Diabetic Association, 15(12), 1031-5.
Blaauwwiekel EE, et al. Apolipoprotein E Genotype Is a Determinant of Low-density Lipoprotein Cholesterol and of Its Response to a Low-cholesterol Diet in Type 1 Diabetic Patients With Elevated Urinary Albumin Excretion. Diabet Med. 1998;15(12):1031-5. PubMed PMID: 9868977.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E genotype is a determinant of low-density lipoprotein cholesterol and of its response to a low-cholesterol diet in Type 1 diabetic patients with elevated urinary albumin excretion. AU - Blaauwwiekel,E E, AU - Beusekamp,B J, AU - Sluiter,W J, AU - Hoogenberg,K, AU - Dullaart,R P, PY - 1998/12/30/pubmed PY - 1998/12/30/medline PY - 1998/12/30/entrez SP - 1031 EP - 5 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet Med VL - 15 IS - 12 N2 - The effect of the apolipoprotein (apo) E genotype on the lipoprotein response to a 1 year low cholesterol diet (200 mg cholesterol per day) was evaluated in 36 patients with Type 1 diabetes mellitus with albuminuria between 10 and 200 microg min(-1). Apo E genotype was characterized by polymerase chain reaction and restriction isotyping. In 11 IDDM patients with at least one epsilon4 allele (apo E4 group), baseline serum total and low density lipoprotein (LDL) cholesterol were higher (p < 0.05 for both) than in 25 patients without an epsilon4 allele and with at least one epsilon3 allele (apo E3 group). Dietary counselling resulted in a similar decrease in cholesterol intake in both groups, whereas linoleic acid did not change. In the apo E4 group, serum total and LDL cholesterol at follow-up fell (p < 0.01 for both) to levels that were not different from those in the apo E3 group, and the changes in these parameters were greater (p < 0.02) than those in the apo E3 group. We conclude that the apo E4 allele is associated with atherogenic lipoprotein abnormalities in Type 1 DM patients with minor elevations in albuminuria when they use their habitual diet. Apo E4 carrying patients respond better to a low cholesterol diet. SN - 0742-3071 UR - https://www.unboundmedicine.com/medline/citation/9868977/Apolipoprotein_E_genotype_is_a_determinant_of_low_density_lipoprotein_cholesterol_and_of_its_response_to_a_low_cholesterol_diet_in_Type_1_diabetic_patients_with_elevated_urinary_albumin_excretion_ L2 - https://medlineplus.gov/ldlthebadcholesterol.html DB - PRIME DP - Unbound Medicine ER -