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Increased serum thyroid hormone binding and decreased free hormone in chronic active liver disease.
N Engl J Med. 1978 Sep 07; 299(10):510-5.NEJM

Abstract

To determine whether chronic inflammatory disease of the liver increases serum thyroid hormone binding, we measured tri-iodothyronine resin binding ratios in nine patient with primary biliary cirrhosis and in nine with chronic active hepatitis. In each group, the average binding ratio was about 50 per cent higher than in control subjects. Thyroxinebinding globulin, measured by immunoassay in three patients, was elevated. Although average total thyroxine and tri-iodothyronine were increased slightly, the corresponding free hormone concentrations were lower than controls, probably because of decreased thyroid function associated with the high incidence of autoimmune thyroiditis in nonalcoholic (autoimmune) liver disease. Thyroid autoantibodies were found in 13 patients. Impaired hepatic thyroxine-to -tri-iodothyronine conversion may have contributed to the low free tri-iodothyronine. Thyrotropin was elevated in four patients. Because of increased serum thyroid hormone binding in these patients total thyroxine and tri-iodothyronine concentration can be normal despite hypothyroidism.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

98709

Citation

Schussler, G C., et al. "Increased Serum Thyroid Hormone Binding and Decreased Free Hormone in Chronic Active Liver Disease." The New England Journal of Medicine, vol. 299, no. 10, 1978, pp. 510-5.
Schussler GC, Schaffner F, Korn F. Increased serum thyroid hormone binding and decreased free hormone in chronic active liver disease. N Engl J Med. 1978;299(10):510-5.
Schussler, G. C., Schaffner, F., & Korn, F. (1978). Increased serum thyroid hormone binding and decreased free hormone in chronic active liver disease. The New England Journal of Medicine, 299(10), 510-5.
Schussler GC, Schaffner F, Korn F. Increased Serum Thyroid Hormone Binding and Decreased Free Hormone in Chronic Active Liver Disease. N Engl J Med. 1978 Sep 7;299(10):510-5. PubMed PMID: 98709.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased serum thyroid hormone binding and decreased free hormone in chronic active liver disease. AU - Schussler,G C, AU - Schaffner,F, AU - Korn,F, PY - 1978/9/7/pubmed PY - 1978/9/7/medline PY - 1978/9/7/entrez SP - 510 EP - 5 JF - The New England journal of medicine JO - N. Engl. J. Med. VL - 299 IS - 10 N2 - To determine whether chronic inflammatory disease of the liver increases serum thyroid hormone binding, we measured tri-iodothyronine resin binding ratios in nine patient with primary biliary cirrhosis and in nine with chronic active hepatitis. In each group, the average binding ratio was about 50 per cent higher than in control subjects. Thyroxinebinding globulin, measured by immunoassay in three patients, was elevated. Although average total thyroxine and tri-iodothyronine were increased slightly, the corresponding free hormone concentrations were lower than controls, probably because of decreased thyroid function associated with the high incidence of autoimmune thyroiditis in nonalcoholic (autoimmune) liver disease. Thyroid autoantibodies were found in 13 patients. Impaired hepatic thyroxine-to -tri-iodothyronine conversion may have contributed to the low free tri-iodothyronine. Thyrotropin was elevated in four patients. Because of increased serum thyroid hormone binding in these patients total thyroxine and tri-iodothyronine concentration can be normal despite hypothyroidism. SN - 0028-4793 UR - https://www.unboundmedicine.com/medline/citation/98709/Increased_serum_thyroid_hormone_binding_and_decreased_free_hormone_in_chronic_active_liver_disease_ L2 - http://www.nejm.org/doi/full/10.1056/NEJM197809072991003?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -