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Tinea capitis dermatophytes: susceptibility to antifungal drugs tested in vitro and in vivo.
Dermatology. 1998; 197(4):361-7.D

Abstract

BACKGROUND

Tinea capitis is a worldwide-spread infection of the scalp caused by dermatophytes and is predominantly seen in children. The clinical manifestations range from mild scaling lesions to widespread alopecia or highly inflammatory suppurating lesions. Terbinafine and itraconazole seem to be promising therapies with shorter treatment durations than griseofulvin.

OBJECTIVE

The objective of the present study was to test the sensitivity of different species of dermatophytes towards terbinafine and itraconazole, and to compare the results with a retrospective study on 35 immunocompetent patients with tinea capitis who were treated with terbinafine (Lamisil(R)).

METHODS

Minimal inhibitory concentrations (MIC) were measured with an agar dilution method.

RESULTS

Each tested species of dermatophyte was sensitive to terbinafine and itraconazole at different concentration ranges. The MIC for terbinafine ranged from 0.005 to 0.5 microg/ml and for itraconazole from 40 to 80 microg/ml. Microsporum canis was the dermatophyte least sensitive to terbinafine. Our retrospective study showed that the cure rate was excellent for Trichophyton violaceum and T. soudanense, variable for T. mentagrophytes and poor for M. canis and M. langeronii.

CONCLUSIONS

(i) Regarding the results of susceptibility tests obtained with species involved in tinea capitis, clinical efficacy is not related to MIC measured in vitro; (ii) identification of the isolated dermatophyte from tinea capitis seems to be important for choosing the appropriate treatment.

Authors+Show Affiliations

Mycology Laboratory, Département Hospitalier Universitaire Romand de Dermatologie et Vénéréologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9873175

Citation

Mock, M, et al. "Tinea Capitis Dermatophytes: Susceptibility to Antifungal Drugs Tested in Vitro and in Vivo." Dermatology (Basel, Switzerland), vol. 197, no. 4, 1998, pp. 361-7.
Mock M, Monod M, Baudraz-Rosselet F, et al. Tinea capitis dermatophytes: susceptibility to antifungal drugs tested in vitro and in vivo. Dermatology (Basel). 1998;197(4):361-7.
Mock, M., Monod, M., Baudraz-Rosselet, F., & Panizzon, R. G. (1998). Tinea capitis dermatophytes: susceptibility to antifungal drugs tested in vitro and in vivo. Dermatology (Basel, Switzerland), 197(4), 361-7.
Mock M, et al. Tinea Capitis Dermatophytes: Susceptibility to Antifungal Drugs Tested in Vitro and in Vivo. Dermatology (Basel). 1998;197(4):361-7. PubMed PMID: 9873175.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tinea capitis dermatophytes: susceptibility to antifungal drugs tested in vitro and in vivo. AU - Mock,M, AU - Monod,M, AU - Baudraz-Rosselet,F, AU - Panizzon,R G, PY - 1999/1/5/pubmed PY - 2000/8/16/medline PY - 1999/1/5/entrez SP - 361 EP - 7 JF - Dermatology (Basel, Switzerland) JO - Dermatology (Basel) VL - 197 IS - 4 N2 - BACKGROUND: Tinea capitis is a worldwide-spread infection of the scalp caused by dermatophytes and is predominantly seen in children. The clinical manifestations range from mild scaling lesions to widespread alopecia or highly inflammatory suppurating lesions. Terbinafine and itraconazole seem to be promising therapies with shorter treatment durations than griseofulvin. OBJECTIVE: The objective of the present study was to test the sensitivity of different species of dermatophytes towards terbinafine and itraconazole, and to compare the results with a retrospective study on 35 immunocompetent patients with tinea capitis who were treated with terbinafine (Lamisil(R)). METHODS: Minimal inhibitory concentrations (MIC) were measured with an agar dilution method. RESULTS: Each tested species of dermatophyte was sensitive to terbinafine and itraconazole at different concentration ranges. The MIC for terbinafine ranged from 0.005 to 0.5 microg/ml and for itraconazole from 40 to 80 microg/ml. Microsporum canis was the dermatophyte least sensitive to terbinafine. Our retrospective study showed that the cure rate was excellent for Trichophyton violaceum and T. soudanense, variable for T. mentagrophytes and poor for M. canis and M. langeronii. CONCLUSIONS: (i) Regarding the results of susceptibility tests obtained with species involved in tinea capitis, clinical efficacy is not related to MIC measured in vitro; (ii) identification of the isolated dermatophyte from tinea capitis seems to be important for choosing the appropriate treatment. SN - 1018-8665 UR - https://www.unboundmedicine.com/medline/citation/9873175/Tinea_capitis_dermatophytes:_susceptibility_to_antifungal_drugs_tested_in_vitro_and_in_vivo_ L2 - https://www.karger.com?DOI=10.1159/000018032 DB - PRIME DP - Unbound Medicine ER -