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A new model describing the swelling and drug release kinetics from hydroxypropyl methylcellulose tablets.
J Pharm Sci. 1999 Jan; 88(1):65-72.JP

Abstract

A novel mathematical model for the water transport into and drug release from hydroxypropyl methylcellulose (HPMC) tablets is presented. Fick's second law of diffusion is used to describe the mass transfer processes in the three-component system drug/polymer/water. Numerical solutions of the respective set of partial differential equations are provided, considering axial and radial diffusion within cylindrical tablets. It is shown that the diffusion coefficients strongly depend on the water concentration (parameters quantifying this dependence have been determined). Swelling of the device is considered using moving boundary conditions, whereas dissolution processes are neglected. Experiments proved the applicability of the theory. The practical benefit of the new model is to calculate the required shape and dimensions of HPMC tablets to achieve a desired release profile.

Links

Publisher Full Text
linkinghub.elsevier.com
onlinelibrary.wiley.com

Authors+Show Affiliations

Siepmann J
College of Pharmacy, Freie Universität Berlin, Kelchstr. 31, 12169 Berlin, Germany.siepmann@zedat.fu-berlin.de
Podual K
No affiliation info available
Sriwongjanya M
No affiliation info available
Peppas NA
No affiliation info available
Bodmeier R
No affiliation info available

MeSH

AlgorithmsChemical PhenomenaChemistry, PhysicalDiffusionExcipientsHypromellose DerivativesKineticsMethylcelluloseModels, TheoreticalSurface PropertiesTabletsWater

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9874704

Citation

Siepmann, J, et al. "A New Model Describing the Swelling and Drug Release Kinetics From Hydroxypropyl Methylcellulose Tablets." Journal of Pharmaceutical Sciences, vol. 88, no. 1, 1999, pp. 65-72.
Siepmann J, Podual K, Sriwongjanya M, et al. A new model describing the swelling and drug release kinetics from hydroxypropyl methylcellulose tablets. J Pharm Sci. 1999;88(1):65-72.
Siepmann, J., Podual, K., Sriwongjanya, M., Peppas, N. A., & Bodmeier, R. (1999). A new model describing the swelling and drug release kinetics from hydroxypropyl methylcellulose tablets. Journal of Pharmaceutical Sciences, 88(1), 65-72.
Siepmann J, et al. A New Model Describing the Swelling and Drug Release Kinetics From Hydroxypropyl Methylcellulose Tablets. J Pharm Sci. 1999;88(1):65-72. PubMed PMID: 9874704.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A new model describing the swelling and drug release kinetics from hydroxypropyl methylcellulose tablets. AU - Siepmann,J, AU - Podual,K, AU - Sriwongjanya,M, AU - Peppas,N A, AU - Bodmeier,R, PY - 1999/1/6/pubmed PY - 2000/7/19/medline PY - 1999/1/6/entrez SP - 65 EP - 72 JF - Journal of pharmaceutical sciences JO - J Pharm Sci VL - 88 IS - 1 N2 - A novel mathematical model for the water transport into and drug release from hydroxypropyl methylcellulose (HPMC) tablets is presented. Fick's second law of diffusion is used to describe the mass transfer processes in the three-component system drug/polymer/water. Numerical solutions of the respective set of partial differential equations are provided, considering axial and radial diffusion within cylindrical tablets. It is shown that the diffusion coefficients strongly depend on the water concentration (parameters quantifying this dependence have been determined). Swelling of the device is considered using moving boundary conditions, whereas dissolution processes are neglected. Experiments proved the applicability of the theory. The practical benefit of the new model is to calculate the required shape and dimensions of HPMC tablets to achieve a desired release profile. SN - 0022-3549 UR - https://www.unboundmedicine.com/medline/citation/9874704/A_new_model_describing_the_swelling_and_drug_release_kinetics_from_hydroxypropyl_methylcellulose_tablets_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3549(15)50736-3 DB - PRIME DP - Unbound Medicine ER -