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Evaluation of guar gum in the preparation of sustained-release matrix tablets.
Drug Dev Ind Pharm. 1998 Nov; 24(11):1095-9.DD

Abstract

Polymeric hydrophilic matrices are widely used for controlled-release preparations. The process of drug release is controlled by matrix swelling or polymer dissolution. It has been shown that the swelling of guar gum is affected by concentration of drug and viscosity grade of the polymer. This study examines the mechanism of behavior of guar gum in a polymer-drug matrix. The swelling action of guar gum, in turn, is controlled by the rate of water uptake into the matrices. An inverse relationship exists between the drug concentration in the gel and matrix swelling. This implies that guar gum swelling is one of the factors affecting drug release. The swelling behavior of guar gum is therefore useful in predicting drug release.

Authors+Show Affiliations

Dabur Research Foundation, Ghaziabad, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9876566

Citation

Khullar, P, et al. "Evaluation of Guar Gum in the Preparation of Sustained-release Matrix Tablets." Drug Development and Industrial Pharmacy, vol. 24, no. 11, 1998, pp. 1095-9.
Khullar P, Khar RK, Agarwal SP. Evaluation of guar gum in the preparation of sustained-release matrix tablets. Drug Dev Ind Pharm. 1998;24(11):1095-9.
Khullar, P., Khar, R. K., & Agarwal, S. P. (1998). Evaluation of guar gum in the preparation of sustained-release matrix tablets. Drug Development and Industrial Pharmacy, 24(11), 1095-9.
Khullar P, Khar RK, Agarwal SP. Evaluation of Guar Gum in the Preparation of Sustained-release Matrix Tablets. Drug Dev Ind Pharm. 1998;24(11):1095-9. PubMed PMID: 9876566.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of guar gum in the preparation of sustained-release matrix tablets. AU - Khullar,P, AU - Khar,R K, AU - Agarwal,S P, PY - 1999/1/7/pubmed PY - 1999/1/7/medline PY - 1999/1/7/entrez SP - 1095 EP - 9 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 24 IS - 11 N2 - Polymeric hydrophilic matrices are widely used for controlled-release preparations. The process of drug release is controlled by matrix swelling or polymer dissolution. It has been shown that the swelling of guar gum is affected by concentration of drug and viscosity grade of the polymer. This study examines the mechanism of behavior of guar gum in a polymer-drug matrix. The swelling action of guar gum, in turn, is controlled by the rate of water uptake into the matrices. An inverse relationship exists between the drug concentration in the gel and matrix swelling. This implies that guar gum swelling is one of the factors affecting drug release. The swelling behavior of guar gum is therefore useful in predicting drug release. SN - 0363-9045 UR - https://www.unboundmedicine.com/medline/citation/9876566/Evaluation_of_guar_gum_in_the_preparation_of_sustained_release_matrix_tablets_ L2 - https://www.tandfonline.com/doi/full/10.3109/03639049809089955 DB - PRIME DP - Unbound Medicine ER -