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Simultaneous determination of pseudoephidrine HCl (PSE) and terfanidine (TER) from formulations by reversed-phase ion pair high-performance liquid chromatography (RP-HPLC).
Drug Dev Ind Pharm. 1998 Mar; 24(3):219-23.DD

Abstract

A new simple, precise, rapid, and selective reversed-phase ion pair high-performance liquid chromatography (RP-HPLC) method has been developed for the simultaneous determination of pseudoephidrine (PSE) and terfanidine (TER) from tablets using 60:15:25 acetontrile:methanol:water (v/v) containing 2.9 g sodium lauryl sulfate/liter, pH adjusted to 3.1 using phosphoric acid as a mobile phase and C18 Spherisorb ODS 2 (3 microns, 5 cm x 4.6 mm i.d.) as stationary phase. Detection was carried out using a UV detector at 254 nm. A constant flow of 1.0 ml/min was maintained throughout the analysis. Retention times for PSE and TER were 1.90 and 7.35 min, respectively. Linearity range and percentage recoveries for PSE and TER were 24-1200 and 12-600 micrograms/ml, and 100.01 and 100.4%, respectively.

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Authors+Show Affiliations

Argekar AP
Department of Chemistry, Institute of Science, Mumbai, India.
Shah SJ
No affiliation info available
Raj SV
No affiliation info available

MeSH

CalibrationChromatography, High Pressure LiquidEphedrineSolutionsSpectrophotometry, UltravioletTabletsTerfenadine

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9876578

Citation

Argekar, A P., et al. "Simultaneous Determination of Pseudoephidrine HCl (PSE) and Terfanidine (TER) From Formulations By Reversed-phase Ion Pair High-performance Liquid Chromatography (RP-HPLC)." Drug Development and Industrial Pharmacy, vol. 24, no. 3, 1998, pp. 219-23.
Argekar AP, Shah SJ, Raj SV. Simultaneous determination of pseudoephidrine HCl (PSE) and terfanidine (TER) from formulations by reversed-phase ion pair high-performance liquid chromatography (RP-HPLC). Drug Dev Ind Pharm. 1998;24(3):219-23.
Argekar, A. P., Shah, S. J., & Raj, S. V. (1998). Simultaneous determination of pseudoephidrine HCl (PSE) and terfanidine (TER) from formulations by reversed-phase ion pair high-performance liquid chromatography (RP-HPLC). Drug Development and Industrial Pharmacy, 24(3), 219-23.
Argekar AP, Shah SJ, Raj SV. Simultaneous Determination of Pseudoephidrine HCl (PSE) and Terfanidine (TER) From Formulations By Reversed-phase Ion Pair High-performance Liquid Chromatography (RP-HPLC). Drug Dev Ind Pharm. 1998;24(3):219-23. PubMed PMID: 9876578.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simultaneous determination of pseudoephidrine HCl (PSE) and terfanidine (TER) from formulations by reversed-phase ion pair high-performance liquid chromatography (RP-HPLC). AU - Argekar,A P, AU - Shah,S J, AU - Raj,S V, PY - 1999/1/7/pubmed PY - 1999/1/7/medline PY - 1999/1/7/entrez SP - 219 EP - 23 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 24 IS - 3 N2 - A new simple, precise, rapid, and selective reversed-phase ion pair high-performance liquid chromatography (RP-HPLC) method has been developed for the simultaneous determination of pseudoephidrine (PSE) and terfanidine (TER) from tablets using 60:15:25 acetontrile:methanol:water (v/v) containing 2.9 g sodium lauryl sulfate/liter, pH adjusted to 3.1 using phosphoric acid as a mobile phase and C18 Spherisorb ODS 2 (3 microns, 5 cm x 4.6 mm i.d.) as stationary phase. Detection was carried out using a UV detector at 254 nm. A constant flow of 1.0 ml/min was maintained throughout the analysis. Retention times for PSE and TER were 1.90 and 7.35 min, respectively. Linearity range and percentage recoveries for PSE and TER were 24-1200 and 12-600 micrograms/ml, and 100.01 and 100.4%, respectively. SN - 0363-9045 UR - https://www.unboundmedicine.com/medline/citation/9876578/Simultaneous_determination_of_pseudoephidrine_HCl__PSE__and_terfanidine__TER__from_formulations_by_reversed_phase_ion_pair_high_performance_liquid_chromatography__RP_HPLC__ L2 - https://www.tandfonline.com/doi/full/10.3109/03639049809085613 DB - PRIME DP - Unbound Medicine ER -