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Study of standard tablet formulation based on fluidized-bed granulation.
Drug Dev Ind Pharm. 1998 Mar; 24(3):225-33.DD

Abstract

In this study, acetaminophen, ascorbic acid, and ethenzamide were selected as model drugs for tableting granules. Agitation and fluidized-bed granulation were carried out at three drug contents of 30, 50, and 70%. Compared with agitation granulation, granules made by fluidized-bed granulation showed superior compressibility with wide formulation allowance for drug type and amount. Fluidized-bed granulation resulted in less granule hardness and greater plastic deformability. The granules had considerable compactness and for tablets containing 70% ethenzamide, prolonged disintegration and dissolution times were noted. These are typical features of granules produced by fluidized-bed granulation.

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Authors+Show Affiliations

Sunada H
Faculty of Pharmacy, Meijo University, Nagoya, Japan.
Hasegawa M
No affiliation info available
Makino T
No affiliation info available
Sakamoto H
No affiliation info available
Fujita K
No affiliation info available
Tanino T
No affiliation info available
Kokubo H
No affiliation info available
Kawaguchi T
No affiliation info available

MeSH

AcetaminophenAscorbic AcidDrug CompoundingExcipientsHardness TestsMicroscopy, Electron, ScanningParticle SizePowdersSalicylamidesSolubilityTablets

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9876579

Citation

Sunada, H, et al. "Study of Standard Tablet Formulation Based On Fluidized-bed Granulation." Drug Development and Industrial Pharmacy, vol. 24, no. 3, 1998, pp. 225-33.
Sunada H, Hasegawa M, Makino T, et al. Study of standard tablet formulation based on fluidized-bed granulation. Drug Dev Ind Pharm. 1998;24(3):225-33.
Sunada, H., Hasegawa, M., Makino, T., Sakamoto, H., Fujita, K., Tanino, T., Kokubo, H., & Kawaguchi, T. (1998). Study of standard tablet formulation based on fluidized-bed granulation. Drug Development and Industrial Pharmacy, 24(3), 225-33.
Sunada H, et al. Study of Standard Tablet Formulation Based On Fluidized-bed Granulation. Drug Dev Ind Pharm. 1998;24(3):225-33. PubMed PMID: 9876579.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Study of standard tablet formulation based on fluidized-bed granulation. AU - Sunada,H, AU - Hasegawa,M, AU - Makino,T, AU - Sakamoto,H, AU - Fujita,K, AU - Tanino,T, AU - Kokubo,H, AU - Kawaguchi,T, PY - 1999/1/7/pubmed PY - 1999/1/7/medline PY - 1999/1/7/entrez SP - 225 EP - 33 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 24 IS - 3 N2 - In this study, acetaminophen, ascorbic acid, and ethenzamide were selected as model drugs for tableting granules. Agitation and fluidized-bed granulation were carried out at three drug contents of 30, 50, and 70%. Compared with agitation granulation, granules made by fluidized-bed granulation showed superior compressibility with wide formulation allowance for drug type and amount. Fluidized-bed granulation resulted in less granule hardness and greater plastic deformability. The granules had considerable compactness and for tablets containing 70% ethenzamide, prolonged disintegration and dissolution times were noted. These are typical features of granules produced by fluidized-bed granulation. SN - 0363-9045 UR - https://www.unboundmedicine.com/medline/citation/9876579/Study_of_standard_tablet_formulation_based_on_fluidized_bed_granulation_ L2 - https://www.tandfonline.com/doi/full/10.3109/03639049809085614 DB - PRIME DP - Unbound Medicine ER -