Tags

Type your tag names separated by a space and hit enter

Alternative solvent-free preparation methods for felodipine surface solid dispersions.
Drug Dev Ind Pharm. 1998 Apr; 24(4):359-63.DD

Abstract

Surface solid dispersions were prepared via physical mixture and were either heated in a vacuum dryer or in a microwave oven for different periods of time. The physical state of felodipine in solid dispersions was studied using differential scanning calorimetry and x-ray powder diffractometry. USP paddle method was used for felodipine dissolution studies. The use of vacuum or microwave energy led to a significant improvement of felodipine dissolution which was caused partly by the amorphous state of felodipine and a large surface area of amorphous silicon dioxide.

Authors+Show Affiliations

Lek Pharmaceutical and Chemical Company d.d., Research and Development Division, Ljubljana, Slovenia.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

9876596

Citation

Kerc, J, et al. "Alternative Solvent-free Preparation Methods for Felodipine Surface Solid Dispersions." Drug Development and Industrial Pharmacy, vol. 24, no. 4, 1998, pp. 359-63.
Kerc J, Srcic S, Kofler B. Alternative solvent-free preparation methods for felodipine surface solid dispersions. Drug Dev Ind Pharm. 1998;24(4):359-63.
Kerc, J., Srcic, S., & Kofler, B. (1998). Alternative solvent-free preparation methods for felodipine surface solid dispersions. Drug Development and Industrial Pharmacy, 24(4), 359-63.
Kerc J, Srcic S, Kofler B. Alternative Solvent-free Preparation Methods for Felodipine Surface Solid Dispersions. Drug Dev Ind Pharm. 1998;24(4):359-63. PubMed PMID: 9876596.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alternative solvent-free preparation methods for felodipine surface solid dispersions. AU - Kerc,J, AU - Srcic,S, AU - Kofler,B, PY - 1999/1/7/pubmed PY - 1999/1/7/medline PY - 1999/1/7/entrez SP - 359 EP - 63 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 24 IS - 4 N2 - Surface solid dispersions were prepared via physical mixture and were either heated in a vacuum dryer or in a microwave oven for different periods of time. The physical state of felodipine in solid dispersions was studied using differential scanning calorimetry and x-ray powder diffractometry. USP paddle method was used for felodipine dissolution studies. The use of vacuum or microwave energy led to a significant improvement of felodipine dissolution which was caused partly by the amorphous state of felodipine and a large surface area of amorphous silicon dioxide. SN - 0363-9045 UR - https://www.unboundmedicine.com/medline/citation/9876596/Alternative_solvent_free_preparation_methods_for_felodipine_surface_solid_dispersions_ L2 - https://www.tandfonline.com/doi/full/10.3109/03639049809085631 DB - PRIME DP - Unbound Medicine ER -