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Preparation, characterization, and dissolution studies of ibuprofen solid dispersions using polyethylene glycol (PEG), talc, and PEG-talc as dispersion carriers.
Drug Dev Ind Pharm. 1998 May; 24(5):455-62.DD

Abstract

Solid dispersions of ibuprofen (IBF) were prepared by solvent evaporation method using polyethylene glycol 10000 (PEG), talc, and PEG-talc as dispersion carriers. The drug-carrier(s) interactions in the solid state were investigated using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and x-ray diffraction analysis. Interactions in the solution were studied by performing dissolution experiments. No important and well-defined chemical interaction was found between the ingredients. The increase in the IBF dissolution rate from the solid dispersions with the carriers used in this study could be attributed to several factors such as improved wettability, local solubilization, and drug particle size reduction.

Authors+Show Affiliations

Zhong Kun Pharmaceutical Research Institute, School of Pharmacy, China Pharmaceutical University, Nanjing, People's Republic of China.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

9876608

Citation

Khan, G M., and Z Jiabi. "Preparation, Characterization, and Dissolution Studies of Ibuprofen Solid Dispersions Using Polyethylene Glycol (PEG), Talc, and PEG-talc as Dispersion Carriers." Drug Development and Industrial Pharmacy, vol. 24, no. 5, 1998, pp. 455-62.
Khan GM, Jiabi Z. Preparation, characterization, and dissolution studies of ibuprofen solid dispersions using polyethylene glycol (PEG), talc, and PEG-talc as dispersion carriers. Drug Dev Ind Pharm. 1998;24(5):455-62.
Khan, G. M., & Jiabi, Z. (1998). Preparation, characterization, and dissolution studies of ibuprofen solid dispersions using polyethylene glycol (PEG), talc, and PEG-talc as dispersion carriers. Drug Development and Industrial Pharmacy, 24(5), 455-62.
Khan GM, Jiabi Z. Preparation, Characterization, and Dissolution Studies of Ibuprofen Solid Dispersions Using Polyethylene Glycol (PEG), Talc, and PEG-talc as Dispersion Carriers. Drug Dev Ind Pharm. 1998;24(5):455-62. PubMed PMID: 9876608.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation, characterization, and dissolution studies of ibuprofen solid dispersions using polyethylene glycol (PEG), talc, and PEG-talc as dispersion carriers. AU - Khan,G M, AU - Jiabi,Z, PY - 1999/1/7/pubmed PY - 1999/1/7/medline PY - 1999/1/7/entrez SP - 455 EP - 62 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 24 IS - 5 N2 - Solid dispersions of ibuprofen (IBF) were prepared by solvent evaporation method using polyethylene glycol 10000 (PEG), talc, and PEG-talc as dispersion carriers. The drug-carrier(s) interactions in the solid state were investigated using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and x-ray diffraction analysis. Interactions in the solution were studied by performing dissolution experiments. No important and well-defined chemical interaction was found between the ingredients. The increase in the IBF dissolution rate from the solid dispersions with the carriers used in this study could be attributed to several factors such as improved wettability, local solubilization, and drug particle size reduction. SN - 0363-9045 UR - https://www.unboundmedicine.com/medline/citation/9876608/Preparation_characterization_and_dissolution_studies_of_ibuprofen_solid_dispersions_using_polyethylene_glycol__PEG__talc_and_PEG_talc_as_dispersion_carriers_ DB - PRIME DP - Unbound Medicine ER -