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Product development studies on the tablet formulation of ibuprofen to improve bioavailability.
Drug Dev Ind Pharm. 1998 May; 24(5):473-7.DD

Abstract

To improve the bioavailability of ibuprofen, a thorough preformulation trial was undertaken. As a part of these studies, particle size of the drug, solubility-pH profile, and pH-partition coefficient profile were studied. The probability of improving solubility by solid dispersion technique was also investigated. The effects of different binding agents and incorporation of various proportions of sodium lauryl sulfate on the release rate of ibuprofen were also studied. The in vitro release profiles of the developed tablets showed superiority over the popular marketed tablets.

Authors+Show Affiliations

Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

9876610

Citation

Ghosh, L K., et al. "Product Development Studies On the Tablet Formulation of Ibuprofen to Improve Bioavailability." Drug Development and Industrial Pharmacy, vol. 24, no. 5, 1998, pp. 473-7.
Ghosh LK, Ghosh NC, Chatterjee M, et al. Product development studies on the tablet formulation of ibuprofen to improve bioavailability. Drug Dev Ind Pharm. 1998;24(5):473-7.
Ghosh, L. K., Ghosh, N. C., Chatterjee, M., & Gupta, B. K. (1998). Product development studies on the tablet formulation of ibuprofen to improve bioavailability. Drug Development and Industrial Pharmacy, 24(5), 473-7.
Ghosh LK, et al. Product Development Studies On the Tablet Formulation of Ibuprofen to Improve Bioavailability. Drug Dev Ind Pharm. 1998;24(5):473-7. PubMed PMID: 9876610.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Product development studies on the tablet formulation of ibuprofen to improve bioavailability. AU - Ghosh,L K, AU - Ghosh,N C, AU - Chatterjee,M, AU - Gupta,B K, PY - 1999/1/7/pubmed PY - 1999/1/7/medline PY - 1999/1/7/entrez SP - 473 EP - 7 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 24 IS - 5 N2 - To improve the bioavailability of ibuprofen, a thorough preformulation trial was undertaken. As a part of these studies, particle size of the drug, solubility-pH profile, and pH-partition coefficient profile were studied. The probability of improving solubility by solid dispersion technique was also investigated. The effects of different binding agents and incorporation of various proportions of sodium lauryl sulfate on the release rate of ibuprofen were also studied. The in vitro release profiles of the developed tablets showed superiority over the popular marketed tablets. SN - 0363-9045 UR - https://www.unboundmedicine.com/medline/citation/9876610/Product_development_studies_on_the_tablet_formulation_of_ibuprofen_to_improve_bioavailability_ L2 - https://www.tandfonline.com/doi/full/10.3109/03639049809085645 DB - PRIME DP - Unbound Medicine ER -