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Evaluation of hydrogel-based controlled-release niacin tablets.
Drug Dev Ind Pharm. 1998 May; 24(5):479-83.DD

Abstract

Matrix-based controlled-release niacin tablets were formulated using guar gum. The effect on the in vitro dissolution profile was examined using variable guar gum content in the formulation. It was observed that the dissolution profile declined with the increase in the guar gum content in the tablet. The in vitro dissolution profile was also observed under different pH conditions and there was no marked change. The moisture content of granules also did not cause any considerable change in dissolution profile. Three different strength Niacin controlled-release tablets, including 500 mg, were prepared and it was found that applying the same variables of different guar gum content and moisture content of granules resulted in a very insignificant change in the in vitro dissolution profile. The experimental formulation compared well with commercial products and met the proposed standards for controlled-release products.

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Authors+Show Affiliations

Khullar P
Dabur Research Foundation, Ghaziabad, India.
Khar RK
No affiliation info available
Agarwal SP
No affiliation info available

MeSH

Chemistry, PharmaceuticalDelayed-Action PreparationsDrug StabilityGalactansHumansHydrogelsHydrogen-Ion ConcentrationIn Vitro TechniquesMannansNiacinPharmaceutical VehiclesPlant GumsTabletsViscosityWater

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

9876611

Citation

Khullar, P, et al. "Evaluation of Hydrogel-based Controlled-release Niacin Tablets." Drug Development and Industrial Pharmacy, vol. 24, no. 5, 1998, pp. 479-83.
Khullar P, Khar RK, Agarwal SP. Evaluation of hydrogel-based controlled-release niacin tablets. Drug Dev Ind Pharm. 1998;24(5):479-83.
Khullar, P., Khar, R. K., & Agarwal, S. P. (1998). Evaluation of hydrogel-based controlled-release niacin tablets. Drug Development and Industrial Pharmacy, 24(5), 479-83.
Khullar P, Khar RK, Agarwal SP. Evaluation of Hydrogel-based Controlled-release Niacin Tablets. Drug Dev Ind Pharm. 1998;24(5):479-83. PubMed PMID: 9876611.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of hydrogel-based controlled-release niacin tablets. AU - Khullar,P, AU - Khar,R K, AU - Agarwal,S P, PY - 1999/1/7/pubmed PY - 1999/1/7/medline PY - 1999/1/7/entrez SP - 479 EP - 83 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 24 IS - 5 N2 - Matrix-based controlled-release niacin tablets were formulated using guar gum. The effect on the in vitro dissolution profile was examined using variable guar gum content in the formulation. It was observed that the dissolution profile declined with the increase in the guar gum content in the tablet. The in vitro dissolution profile was also observed under different pH conditions and there was no marked change. The moisture content of granules also did not cause any considerable change in dissolution profile. Three different strength Niacin controlled-release tablets, including 500 mg, were prepared and it was found that applying the same variables of different guar gum content and moisture content of granules resulted in a very insignificant change in the in vitro dissolution profile. The experimental formulation compared well with commercial products and met the proposed standards for controlled-release products. SN - 0363-9045 UR - https://www.unboundmedicine.com/medline/citation/9876611/Evaluation_of_hydrogel_based_controlled_release_niacin_tablets_ L2 - https://www.tandfonline.com/doi/full/10.3109/03639049809085646 DB - PRIME DP - Unbound Medicine ER -