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Decreased CD4+/CD8+ ratio in major type of recurrent aphthous ulcers: comparing major to minor types of ulcers.
Asian Pac J Allergy Immunol. 1998 Jun-Sep; 16(2-3):75-9.AP

Abstract

The etiology of recurrent aphthous ulcers (RAU) has not been clearly defined. However, the results of several studies indicated the evidence of the role of immunological factors. The association between the regulator and effector component of the immune system in RAU needs clarifying by comparing major and minor type of RAU patients. The proportion of peripheral blood lymphocyte subsets were enumerated during active ulcer phase and analyzed in relation to ulcer types. Nineteen patients with RAU (12 minor type and 7 major type) and 8 healthy volunteers, of both sexes, aged 24-54 years old were tested. CD3+ (T cell), CD4+ (helper T cell), CD8+ (suppressor/cytotoxic T cell), CD19+ (B cell), and CD16+/CD56+ (NK cell) were determined by using appropriate monoclonal antibodies in double colored flow cytometry. The results showed that CD4+ was lower in RAU than control (P < 0.01). Comparing both types of RAU, it appeared that CD8+ was higher in the major type than the minor type (p < 0.01); CD4+/CD8+ ratio in the major type was lower than the minor type (P < 0.01). There was no difference in CD19+ and CD16+/CD56+ between any groups compared. The finding indicated that RAU was associated with abnormal proportions of CD4+ and CD8+ cells which was dependent on the severity of the lesion.

Authors+Show Affiliations

Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Jakarta.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9876944

Citation

Bachtiar, E W., et al. "Decreased CD4+/CD8+ Ratio in Major Type of Recurrent Aphthous Ulcers: Comparing Major to Minor Types of Ulcers." Asian Pacific Journal of Allergy and Immunology, vol. 16, no. 2-3, 1998, pp. 75-9.
Bachtiar EW, Cornain S, Siregar B, et al. Decreased CD4+/CD8+ ratio in major type of recurrent aphthous ulcers: comparing major to minor types of ulcers. Asian Pac J Allergy Immunol. 1998;16(2-3):75-9.
Bachtiar, E. W., Cornain, S., Siregar, B., & Raharjo, T. W. (1998). Decreased CD4+/CD8+ ratio in major type of recurrent aphthous ulcers: comparing major to minor types of ulcers. Asian Pacific Journal of Allergy and Immunology, 16(2-3), 75-9.
Bachtiar EW, et al. Decreased CD4+/CD8+ Ratio in Major Type of Recurrent Aphthous Ulcers: Comparing Major to Minor Types of Ulcers. Asian Pac J Allergy Immunol. 1998 Jun-Sep;16(2-3):75-9. PubMed PMID: 9876944.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decreased CD4+/CD8+ ratio in major type of recurrent aphthous ulcers: comparing major to minor types of ulcers. AU - Bachtiar,E W, AU - Cornain,S, AU - Siregar,B, AU - Raharjo,T W, PY - 1999/1/7/pubmed PY - 1999/1/7/medline PY - 1999/1/7/entrez SP - 75 EP - 9 JF - Asian Pacific journal of allergy and immunology JO - Asian Pac J Allergy Immunol VL - 16 IS - 2-3 N2 - The etiology of recurrent aphthous ulcers (RAU) has not been clearly defined. However, the results of several studies indicated the evidence of the role of immunological factors. The association between the regulator and effector component of the immune system in RAU needs clarifying by comparing major and minor type of RAU patients. The proportion of peripheral blood lymphocyte subsets were enumerated during active ulcer phase and analyzed in relation to ulcer types. Nineteen patients with RAU (12 minor type and 7 major type) and 8 healthy volunteers, of both sexes, aged 24-54 years old were tested. CD3+ (T cell), CD4+ (helper T cell), CD8+ (suppressor/cytotoxic T cell), CD19+ (B cell), and CD16+/CD56+ (NK cell) were determined by using appropriate monoclonal antibodies in double colored flow cytometry. The results showed that CD4+ was lower in RAU than control (P < 0.01). Comparing both types of RAU, it appeared that CD8+ was higher in the major type than the minor type (p < 0.01); CD4+/CD8+ ratio in the major type was lower than the minor type (P < 0.01). There was no difference in CD19+ and CD16+/CD56+ between any groups compared. The finding indicated that RAU was associated with abnormal proportions of CD4+ and CD8+ cells which was dependent on the severity of the lesion. SN - 0125-877X UR - https://www.unboundmedicine.com/medline/citation/9876944/Decreased_CD4+/CD8+_ratio_in_major_type_of_recurrent_aphthous_ulcers:_comparing_major_to_minor_types_of_ulcers_ L2 - https://medlineplus.gov/cankersores.html DB - PRIME DP - Unbound Medicine ER -