Tags

Type your tag names separated by a space and hit enter

Epidermal growth factor stimulates the recovery of glucose absorption after small bowel transplantation.
J Surg Res. 1998 Dec; 80(2):315-9.JS

Abstract

Epidermal growth factor (EGF) has been reported to enhance adaptation in damaged intestines following massive intestinal resection. Studies were performed to determine whether EGF influences the recovery of intestinal function after small bowel transplantation in rats. Recipient Lewis rats underwent resection of the distal 80% of the small bowel, which was replaced with a 20-cm isograft. EGF (30 microg/kg/day) or its vehicle (control) was infused intraperitoneally for 3 days after transplantation. After 7 days, the graft was isolated for morphologic studies and was used for analysis of glucose and water absorption and the expression of sodium glucose cotransporter (SGLT1). These were used as indicators of functional adaptation. The EGF-treated group exhibited significantly increased mucosal villous height, crypt cell proliferation, glucose and water absorption, and expression of SGLT1 protein compared to the control group. No significant differences were found in body weight change or crypt depth between the two groups. These results demonstrate that EGF augments structural and functional adaptation of intestinal grafts in rats. EGF may be useful after intestinal transplantation in patients with short bowel syndrome.

Authors+Show Affiliations

Second Department of Surgery, Kansai Medical University, Osaka, 570-0075l, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9878331

Citation

Kato, Y, et al. "Epidermal Growth Factor Stimulates the Recovery of Glucose Absorption After Small Bowel Transplantation." The Journal of Surgical Research, vol. 80, no. 2, 1998, pp. 315-9.
Kato Y, Hamada Y, Ito S, et al. Epidermal growth factor stimulates the recovery of glucose absorption after small bowel transplantation. J Surg Res. 1998;80(2):315-9.
Kato, Y., Hamada, Y., Ito, S., Okumura, T., & Hioki, K. (1998). Epidermal growth factor stimulates the recovery of glucose absorption after small bowel transplantation. The Journal of Surgical Research, 80(2), 315-9.
Kato Y, et al. Epidermal Growth Factor Stimulates the Recovery of Glucose Absorption After Small Bowel Transplantation. J Surg Res. 1998;80(2):315-9. PubMed PMID: 9878331.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidermal growth factor stimulates the recovery of glucose absorption after small bowel transplantation. AU - Kato,Y, AU - Hamada,Y, AU - Ito,S, AU - Okumura,T, AU - Hioki,K, PY - 1999/1/8/pubmed PY - 1999/1/8/medline PY - 1999/1/8/entrez SP - 315 EP - 9 JF - The Journal of surgical research JO - J Surg Res VL - 80 IS - 2 N2 - Epidermal growth factor (EGF) has been reported to enhance adaptation in damaged intestines following massive intestinal resection. Studies were performed to determine whether EGF influences the recovery of intestinal function after small bowel transplantation in rats. Recipient Lewis rats underwent resection of the distal 80% of the small bowel, which was replaced with a 20-cm isograft. EGF (30 microg/kg/day) or its vehicle (control) was infused intraperitoneally for 3 days after transplantation. After 7 days, the graft was isolated for morphologic studies and was used for analysis of glucose and water absorption and the expression of sodium glucose cotransporter (SGLT1). These were used as indicators of functional adaptation. The EGF-treated group exhibited significantly increased mucosal villous height, crypt cell proliferation, glucose and water absorption, and expression of SGLT1 protein compared to the control group. No significant differences were found in body weight change or crypt depth between the two groups. These results demonstrate that EGF augments structural and functional adaptation of intestinal grafts in rats. EGF may be useful after intestinal transplantation in patients with short bowel syndrome. SN - 0022-4804 UR - https://www.unboundmedicine.com/medline/citation/9878331/Epidermal_growth_factor_stimulates_the_recovery_of_glucose_absorption_after_small_bowel_transplantation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-4804(98)95465-8 DB - PRIME DP - Unbound Medicine ER -