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Bioavailability of ferulic acid.
Biochem Biophys Res Commun. 1998 Dec 18; 253(2):222-7.BB

Abstract

There is a wealth of evidence for the powerful antioxidant properties in vitro of flavonoid components of the diet. However, few studies have been undertaken concerning the hydroxycinnamates, major constituents of fruit, some vegetables, beverages, and grains, particularly the extent to which they are absorbed in vivo from the diet. The study described here has investigated the bioavailability of ferulic acid in humans, from tomato consumption, through the monitoring of the pharmacokinetics of excretion in relation to intake. The results show that the peak time for maximal urinary excretion is approximately 7 h and the recovery of ferulic acid in the urine, on the basis of total free ferulic acid and feruloyl glucuronide excreted, is 11-25% of that ingested.

Authors+Show Affiliations

International Antioxidant Research Centre, Guy's King's College, London, United Kingdom.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9878519

Citation

Bourne, L C., and C Rice-Evans. "Bioavailability of Ferulic Acid." Biochemical and Biophysical Research Communications, vol. 253, no. 2, 1998, pp. 222-7.
Bourne LC, Rice-Evans C. Bioavailability of ferulic acid. Biochem Biophys Res Commun. 1998;253(2):222-7.
Bourne, L. C., & Rice-Evans, C. (1998). Bioavailability of ferulic acid. Biochemical and Biophysical Research Communications, 253(2), 222-7.
Bourne LC, Rice-Evans C. Bioavailability of Ferulic Acid. Biochem Biophys Res Commun. 1998 Dec 18;253(2):222-7. PubMed PMID: 9878519.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioavailability of ferulic acid. AU - Bourne,L C, AU - Rice-Evans,C, PY - 1999/1/8/pubmed PY - 1999/1/8/medline PY - 1999/1/8/entrez SP - 222 EP - 7 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 253 IS - 2 N2 - There is a wealth of evidence for the powerful antioxidant properties in vitro of flavonoid components of the diet. However, few studies have been undertaken concerning the hydroxycinnamates, major constituents of fruit, some vegetables, beverages, and grains, particularly the extent to which they are absorbed in vivo from the diet. The study described here has investigated the bioavailability of ferulic acid in humans, from tomato consumption, through the monitoring of the pharmacokinetics of excretion in relation to intake. The results show that the peak time for maximal urinary excretion is approximately 7 h and the recovery of ferulic acid in the urine, on the basis of total free ferulic acid and feruloyl glucuronide excreted, is 11-25% of that ingested. SN - 0006-291X UR - https://www.unboundmedicine.com/medline/citation/9878519/Bioavailability_of_ferulic_acid_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(98)99681-4 DB - PRIME DP - Unbound Medicine ER -