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[GB virus-C/hepatitis G virus--discovery, epidemiology, diagnosis and clinical relevance].
Z Gastroenterol. 1998 Nov; 36(11):997-1008.ZG

Abstract

Recently, two isolates of a new virus, designated GB virus C (GBV-C) and hepatitis G virus (HGV) were identified. Genomic organization place them in the family Flaviviridae, which includes HCV. A classification of GBV-C/HGV strains into at least three genotypes (West Africa, Europe/North America, Asia) has been proposed. GBV-C/HGV has a positive-stranded, linear RNA genome possessing a large open reading frame that encodes a single large polyprotein. As a possible genomic defect no core protein has yet been identified in GBV-C/HGV isolates. Whether GBV-C/HGV can be classified as a hepatotropic virus with replication in the liver is under discussion. The prevalence in the general population is high (2%). GBV-C/HGV is transmitted parenterally e.g., by transfusion of blood and blood products. Furthermore, cases of vertical and horizontal transmission are reported. Detection of GBV-C/HGV infection is exclusively possible by reverse transcription polymerase chain reaction (RT PCR). E2-specific antibodies are associated with loss of detectable GBV-C/HGV RNA and appear to indicate recovery from GBV-C/HGV infection. An acute icteric state with transient elevation of aminotransferases in association with GBV-C/HGV infection may exist. These cases are rare and approximately only 0.3% of persons with acute viral hepatitis are infected with GBV-C/HGV alone. Whether GBV-C/HGV is a cause of fulminant hepatic failure has not yet been proven. Persistent viremia of the GBV-C/HGV infection is frequent but is not related to chronic liver disease. Since no other chronic diseases associated with GBV-C/HGV infection could yet be identified, chronic GBV-C/HGV infections appear to be without clinical significance. GBV-C/HGV and hepatitis B or C virus (HBV, HCV) coinfection seem not to interfere with the outcome of HBV-respective HCV-related liver disease. The cause of the majority of cases with non-A-E viral hepatitis remains unknown and other yet undiscovered hepatic viruses must exist.

Authors+Show Affiliations

Medizinische Klinik II, Klinikum der J.-W.-Goethe-Universität Frankfurt, Frankfurt am Main.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

ger

PubMed ID

9880826

Citation

Sarrazin, C, et al. "[GB virus-C/hepatitis G Virus--discovery, Epidemiology, Diagnosis and Clinical Relevance]." Zeitschrift Fur Gastroenterologie, vol. 36, no. 11, 1998, pp. 997-1008.
Sarrazin C, Roth WK, Zeuzem S. [GB virus-C/hepatitis G virus--discovery, epidemiology, diagnosis and clinical relevance]. Z Gastroenterol. 1998;36(11):997-1008.
Sarrazin, C., Roth, W. K., & Zeuzem, S. (1998). [GB virus-C/hepatitis G virus--discovery, epidemiology, diagnosis and clinical relevance]. Zeitschrift Fur Gastroenterologie, 36(11), 997-1008.
Sarrazin C, Roth WK, Zeuzem S. [GB virus-C/hepatitis G Virus--discovery, Epidemiology, Diagnosis and Clinical Relevance]. Z Gastroenterol. 1998;36(11):997-1008. PubMed PMID: 9880826.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [GB virus-C/hepatitis G virus--discovery, epidemiology, diagnosis and clinical relevance]. AU - Sarrazin,C, AU - Roth,W K, AU - Zeuzem,S, PY - 1999/1/9/pubmed PY - 1999/1/9/medline PY - 1999/1/9/entrez SP - 997 EP - 1008 JF - Zeitschrift fur Gastroenterologie JO - Z Gastroenterol VL - 36 IS - 11 N2 - Recently, two isolates of a new virus, designated GB virus C (GBV-C) and hepatitis G virus (HGV) were identified. Genomic organization place them in the family Flaviviridae, which includes HCV. A classification of GBV-C/HGV strains into at least three genotypes (West Africa, Europe/North America, Asia) has been proposed. GBV-C/HGV has a positive-stranded, linear RNA genome possessing a large open reading frame that encodes a single large polyprotein. As a possible genomic defect no core protein has yet been identified in GBV-C/HGV isolates. Whether GBV-C/HGV can be classified as a hepatotropic virus with replication in the liver is under discussion. The prevalence in the general population is high (2%). GBV-C/HGV is transmitted parenterally e.g., by transfusion of blood and blood products. Furthermore, cases of vertical and horizontal transmission are reported. Detection of GBV-C/HGV infection is exclusively possible by reverse transcription polymerase chain reaction (RT PCR). E2-specific antibodies are associated with loss of detectable GBV-C/HGV RNA and appear to indicate recovery from GBV-C/HGV infection. An acute icteric state with transient elevation of aminotransferases in association with GBV-C/HGV infection may exist. These cases are rare and approximately only 0.3% of persons with acute viral hepatitis are infected with GBV-C/HGV alone. Whether GBV-C/HGV is a cause of fulminant hepatic failure has not yet been proven. Persistent viremia of the GBV-C/HGV infection is frequent but is not related to chronic liver disease. Since no other chronic diseases associated with GBV-C/HGV infection could yet be identified, chronic GBV-C/HGV infections appear to be without clinical significance. GBV-C/HGV and hepatitis B or C virus (HBV, HCV) coinfection seem not to interfere with the outcome of HBV-respective HCV-related liver disease. The cause of the majority of cases with non-A-E viral hepatitis remains unknown and other yet undiscovered hepatic viruses must exist. SN - 0044-2771 UR - https://www.unboundmedicine.com/medline/citation/9880826/[GB_virus_C/hepatitis_G_virus__discovery_epidemiology_diagnosis_and_clinical_relevance]_ L2 - http://www.diseaseinfosearch.org/result/3332 DB - PRIME DP - Unbound Medicine ER -