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Periodic limb movement disorder and restless legs syndrome in children with attention-deficit hyperactivity disorder.
J Child Neurol 1998; 13(12):588-94JC

Abstract

Sleep disruption can lead to symptoms of attention-deficit hyperactivity disorder (ADHD) in children. Since periodic limb movement disorder and/or restless legs syndrome can cause sleep disruption, we assessed whether these two specific sleep disorders are likely to occur in children with ADHD. We asked a series of 69 consecutive parents of children with ADHD questions about the symptoms of periodic limb movement disorder. Based on a positive response to these periodic limb movement disorder queries, 27 children underwent all-night polysomnography. Eighteen children (aged 2 to 15 years) of the 27 (26% of the 69 children with ADHD) had 5 or more periodic leg movements in sleep per hour of sleep and had complaints of sleep disruption, thus fulfilling the criteria for periodic limb movement disorder. A comparably age- and sex-matched group of children referred to a sleep laboratory for sleep complaints but without ADHD showed only a 5% prevalence (2 of 38 subjects) of periodic leg movements in sleep (P=.017). Eight of the 18 children with ADHD and periodic limb movement disorder and one of the two control patients with periodic limb movement disorder had both a personal and parental history of restless legs syndrome symptomatology. This study further documents the occurrence of periodic limb movement disorder and restless legs syndrome in children and is the first large-scale study establishing a possible comorbidity between ADHD and periodic limb movement disorder. We propose that the sleep disruption associated with periodic limb movement disorder and restless legs syndrome and the motor restlessness of restless legs syndrome while awake could contribute to the inattention and hyperactivity seen in a subgroup of ADHD-diagnosed children.

Authors+Show Affiliations

Pediatric Neurology Department, Carle Clinic and University of Illinois at Urbana-Champaign, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

9881529

Citation

Picchietti, D L., et al. "Periodic Limb Movement Disorder and Restless Legs Syndrome in Children With Attention-deficit Hyperactivity Disorder." Journal of Child Neurology, vol. 13, no. 12, 1998, pp. 588-94.
Picchietti DL, England SJ, Walters AS, et al. Periodic limb movement disorder and restless legs syndrome in children with attention-deficit hyperactivity disorder. J Child Neurol. 1998;13(12):588-94.
Picchietti, D. L., England, S. J., Walters, A. S., Willis, K., & Verrico, T. (1998). Periodic limb movement disorder and restless legs syndrome in children with attention-deficit hyperactivity disorder. Journal of Child Neurology, 13(12), pp. 588-94.
Picchietti DL, et al. Periodic Limb Movement Disorder and Restless Legs Syndrome in Children With Attention-deficit Hyperactivity Disorder. J Child Neurol. 1998;13(12):588-94. PubMed PMID: 9881529.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Periodic limb movement disorder and restless legs syndrome in children with attention-deficit hyperactivity disorder. AU - Picchietti,D L, AU - England,S J, AU - Walters,A S, AU - Willis,K, AU - Verrico,T, PY - 1999/1/9/pubmed PY - 1999/1/9/medline PY - 1999/1/9/entrez SP - 588 EP - 94 JF - Journal of child neurology JO - J. Child Neurol. VL - 13 IS - 12 N2 - Sleep disruption can lead to symptoms of attention-deficit hyperactivity disorder (ADHD) in children. Since periodic limb movement disorder and/or restless legs syndrome can cause sleep disruption, we assessed whether these two specific sleep disorders are likely to occur in children with ADHD. We asked a series of 69 consecutive parents of children with ADHD questions about the symptoms of periodic limb movement disorder. Based on a positive response to these periodic limb movement disorder queries, 27 children underwent all-night polysomnography. Eighteen children (aged 2 to 15 years) of the 27 (26% of the 69 children with ADHD) had 5 or more periodic leg movements in sleep per hour of sleep and had complaints of sleep disruption, thus fulfilling the criteria for periodic limb movement disorder. A comparably age- and sex-matched group of children referred to a sleep laboratory for sleep complaints but without ADHD showed only a 5% prevalence (2 of 38 subjects) of periodic leg movements in sleep (P=.017). Eight of the 18 children with ADHD and periodic limb movement disorder and one of the two control patients with periodic limb movement disorder had both a personal and parental history of restless legs syndrome symptomatology. This study further documents the occurrence of periodic limb movement disorder and restless legs syndrome in children and is the first large-scale study establishing a possible comorbidity between ADHD and periodic limb movement disorder. We propose that the sleep disruption associated with periodic limb movement disorder and restless legs syndrome and the motor restlessness of restless legs syndrome while awake could contribute to the inattention and hyperactivity seen in a subgroup of ADHD-diagnosed children. SN - 0883-0738 UR - https://www.unboundmedicine.com/medline/citation/9881529/Periodic_limb_movement_disorder_and_restless_legs_syndrome_in_children_with_attention_deficit_hyperactivity_disorder_ L2 - http://journals.sagepub.com/doi/full/10.1177/088307389801301202?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -