Tags

Type your tag names separated by a space and hit enter

Low bone mineral density in a case of mosaicism Klinefelter syndrome: rapid response to testosterone therapy.

Abstract

Male hypogonadism has been recognized as one of the major causes of secondary osteoporosis, but most cases seem to be left undiagnosed. We report a 54-year-old case of mosaicism Klinefelter syndrome lacking typical clinical features such as tall stature or low intelligence, who was found to have marked decrease in lumbar bone mineral density (BMD: 0.686 g/cm2) during treatment of diabetes mellitus. In investigation for etiologies of secondary osteoporosis, he was diagnosed as having mosaicism Klinefelter syndrome (XXY/XY/XX). Although he was infertile, he lacked typical clinical features of Klinefelter syndrome. Testosterone replacement was started, which resulted in an increase in BMD up to 0.712 g/cm2 two months after the initiation of therapy. The fact that BMD increased shortly after the initiation of testosterone replacement therapy in the present case supported a beneficial effect of testosterone on BMD, as recently suggested in idiopathic hypogonadotropic hypogonadism. Although the present case was diagnosed as having mosaicism Klinefelter syndrome by investigating etiologies for osteoporosis, it may be stressed that male hypogonadism, in general, should be adequately suspected in the presence of infertility and from the findings of physical examination.

Links

  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Internal Medicine, Hyogo Prefectural Amagasaki Hospital, Japan.

    , , , ,

    Source

    Endocrine journal 45:4 1998 Aug pg 601-4

    MeSH

    Bone Density
    Diabetes Complications
    Diabetes Mellitus
    Humans
    Hypoglycemic Agents
    Insulin
    Klinefelter Syndrome
    Male
    Middle Aged
    Testosterone

    Pub Type(s)

    Case Reports
    Journal Article

    Language

    eng

    PubMed ID

    9881914

    Citation

    Yamauchi, M, et al. "Low Bone Mineral Density in a Case of Mosaicism Klinefelter Syndrome: Rapid Response to Testosterone Therapy." Endocrine Journal, vol. 45, no. 4, 1998, pp. 601-4.
    Yamauchi M, Tadano M, Fukunaga Y, et al. Low bone mineral density in a case of mosaicism Klinefelter syndrome: rapid response to testosterone therapy. Endocr J. 1998;45(4):601-4.
    Yamauchi, M., Tadano, M., Fukunaga, Y., Inoue, D., Minamikawa, J., & Koshiyama, H. (1998). Low bone mineral density in a case of mosaicism Klinefelter syndrome: rapid response to testosterone therapy. Endocrine Journal, 45(4), pp. 601-4.
    Yamauchi M, et al. Low Bone Mineral Density in a Case of Mosaicism Klinefelter Syndrome: Rapid Response to Testosterone Therapy. Endocr J. 1998;45(4):601-4. PubMed PMID: 9881914.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Low bone mineral density in a case of mosaicism Klinefelter syndrome: rapid response to testosterone therapy. AU - Yamauchi,M, AU - Tadano,M, AU - Fukunaga,Y, AU - Inoue,D, AU - Minamikawa,J, AU - Koshiyama,H, PY - 1999/1/9/pubmed PY - 1999/1/9/medline PY - 1999/1/9/entrez SP - 601 EP - 4 JF - Endocrine journal JO - Endocr. J. VL - 45 IS - 4 N2 - Male hypogonadism has been recognized as one of the major causes of secondary osteoporosis, but most cases seem to be left undiagnosed. We report a 54-year-old case of mosaicism Klinefelter syndrome lacking typical clinical features such as tall stature or low intelligence, who was found to have marked decrease in lumbar bone mineral density (BMD: 0.686 g/cm2) during treatment of diabetes mellitus. In investigation for etiologies of secondary osteoporosis, he was diagnosed as having mosaicism Klinefelter syndrome (XXY/XY/XX). Although he was infertile, he lacked typical clinical features of Klinefelter syndrome. Testosterone replacement was started, which resulted in an increase in BMD up to 0.712 g/cm2 two months after the initiation of therapy. The fact that BMD increased shortly after the initiation of testosterone replacement therapy in the present case supported a beneficial effect of testosterone on BMD, as recently suggested in idiopathic hypogonadotropic hypogonadism. Although the present case was diagnosed as having mosaicism Klinefelter syndrome by investigating etiologies for osteoporosis, it may be stressed that male hypogonadism, in general, should be adequately suspected in the presence of infertility and from the findings of physical examination. SN - 0918-8959 UR - https://www.unboundmedicine.com/medline/citation/9881914/Low_bone_mineral_density_in_a_case_of_mosaicism_Klinefelter_syndrome:_rapid_response_to_testosterone_therapy_ L2 - http://joi.jlc.jst.go.jp/JST.Journalarchive/endocrj1993/45.601?from=PubMed DB - PRIME DP - Unbound Medicine ER -