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[Interferon-gamma, the Th1/Th2 paradigm and autoimmune diseases].
Verh K Acad Geneeskd Belg. 1998; 60(4):271-85.VK

Abstract

Autoimmune diseases originate from a rupture in physiological immune tolerance towards self antigens. However, the formation of autoantibodies and autoreactive inflammatory cells is also regulated by the cytokine network, in which interferon-gamma (IFN-gamma), produced by NK and T lymphocytes, occupies a central position. IFN-gamma influences the function of all cell types involved in immune-mediated inflammatory reactions: antigen-presenting cells, cytotoxic and regulatory T lymphocytes, antibody-producing B lymphocytes, endothelial cells and mononuclear phagocytes. Experimental manipulations which affect the production or action of IFN-gamma invariably affect the course of experimentally induced autoimmune diseases in animals, but do so in divergent directions. A current explanatory framework for these actions of IFN-gamma invokes the T helper-1/T helper-2 (Th1/Th2) concept. According to this concept, autoimmune diseases, like other immune reactions, fall apart in two categories depending on whether the T helper lymphocytes assume a Th1 or Th2 profile. IFN-gamma is assumed to fulfill the function of a promotor and effector of the Th1 profile and is associated with inflammation and tissue damage typical for cell-mediated hypersensitivity reactions. Accordingly, IFN-gamma should boost autoimmune diseases of the Th1 type. However, experimental testing of this prediction contradicts this implication and necessitates revision of the function assigned to IFN-gamma in the Th1/Th2 concept.

Authors+Show Affiliations

Rega Instituut, Faculteit Geneeskunde-K.U.-Leuven.

Pub Type(s)

English Abstract
Journal Article

Language

dut

PubMed ID

9883078

Citation

Billiau, A. "[Interferon-gamma, the Th1/Th2 Paradigm and Autoimmune Diseases]." Verhandelingen - Koninklijke Academie Voor Geneeskunde Van Belgie, vol. 60, no. 4, 1998, pp. 271-85.
Billiau A. [Interferon-gamma, the Th1/Th2 paradigm and autoimmune diseases]. Verh K Acad Geneeskd Belg. 1998;60(4):271-85.
Billiau, A. (1998). [Interferon-gamma, the Th1/Th2 paradigm and autoimmune diseases]. Verhandelingen - Koninklijke Academie Voor Geneeskunde Van Belgie, 60(4), 271-85.
Billiau A. [Interferon-gamma, the Th1/Th2 Paradigm and Autoimmune Diseases]. Verh K Acad Geneeskd Belg. 1998;60(4):271-85. PubMed PMID: 9883078.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Interferon-gamma, the Th1/Th2 paradigm and autoimmune diseases]. A1 - Billiau,A, PY - 1999/1/12/pubmed PY - 1999/1/12/medline PY - 1999/1/12/entrez SP - 271 EP - 85 JF - Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie JO - Verh. K. Acad. Geneeskd. Belg. VL - 60 IS - 4 N2 - Autoimmune diseases originate from a rupture in physiological immune tolerance towards self antigens. However, the formation of autoantibodies and autoreactive inflammatory cells is also regulated by the cytokine network, in which interferon-gamma (IFN-gamma), produced by NK and T lymphocytes, occupies a central position. IFN-gamma influences the function of all cell types involved in immune-mediated inflammatory reactions: antigen-presenting cells, cytotoxic and regulatory T lymphocytes, antibody-producing B lymphocytes, endothelial cells and mononuclear phagocytes. Experimental manipulations which affect the production or action of IFN-gamma invariably affect the course of experimentally induced autoimmune diseases in animals, but do so in divergent directions. A current explanatory framework for these actions of IFN-gamma invokes the T helper-1/T helper-2 (Th1/Th2) concept. According to this concept, autoimmune diseases, like other immune reactions, fall apart in two categories depending on whether the T helper lymphocytes assume a Th1 or Th2 profile. IFN-gamma is assumed to fulfill the function of a promotor and effector of the Th1 profile and is associated with inflammation and tissue damage typical for cell-mediated hypersensitivity reactions. Accordingly, IFN-gamma should boost autoimmune diseases of the Th1 type. However, experimental testing of this prediction contradicts this implication and necessitates revision of the function assigned to IFN-gamma in the Th1/Th2 concept. SN - 0302-6469 UR - https://www.unboundmedicine.com/medline/citation/9883078/[Interferon_gamma_the_Th1/Th2_paradigm_and_autoimmune_diseases]_ L2 - http://www.diseaseinfosearch.org/result/675 DB - PRIME DP - Unbound Medicine ER -
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