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Effects of abstinence and family history for alcoholism on platelet adenylyl cyclase activity.
Alcohol Clin Exp Res. 1998 Dec; 22(9):1955-61.AC

Abstract

Platelet adenylyl cyclase (AC) activity was measured in 32 alcohol-dependent subjects and 27 control subjects who were categorized as either family history-positive (FHP) or family history-negative (FHN) for alcoholism. The interview and blood sample collections were performed shortly after cessation of heavy drinking in the alcoholic group, and repeat blood samples were obtained at the end of the first and second weeks of monitored abstinence. Control subjects received the same interview and provided blood samples at the time of the interview. When subjects were not segregated for FHP or FHN status, there were no statistically significant differences in basal, cesium fluoride (CsF)-, or forskolin-stimulated mean AC activities between the controls and the alcoholics, at study entry or with 1 or 2 weeks of abstinence. On the other hand, over the 2-week course of sobriety from heavy drinking, the CsF-stimulated AC activity of FHP alcohol-dependent subjects decreased significantly (p = 0.03). FHP alcohol-dependent subjects after 2 weeks of sobriety had significantly lower mean CsF-stimulated AC activity than FHN controls (p = 0.04), whereas the FHN alcoholic subjects' CsF-stimulated AC activity did not differ significantly from FHN controls at this point in time. When all subjects were pooled and then categorized as either FHP or FHN, there was a significant difference in mean CsF-stimulated AC activity (p = 0.02) between the FHP and FHN subject groups. Genetic factors and abstinence appear to have roles in determining low platelet AC activity in alcoholic and nonalcoholic subjects. CsF-stimulated platelet AC activity, in particular, appears to act as a trait marker for a genetic vulnerability to developing alcoholism, but recent heavy drinking in male alcoholics is a factor that can mask differences between FHP and FHN subjects.

Authors+Show Affiliations

Department of Psychiatry, University of Colorado Health Sciences Center, Denver, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9884138

Citation

Menninger, J A., et al. "Effects of Abstinence and Family History for Alcoholism On Platelet Adenylyl Cyclase Activity." Alcoholism, Clinical and Experimental Research, vol. 22, no. 9, 1998, pp. 1955-61.
Menninger JA, Barón AE, Tabakoff B. Effects of abstinence and family history for alcoholism on platelet adenylyl cyclase activity. Alcohol Clin Exp Res. 1998;22(9):1955-61.
Menninger, J. A., Barón, A. E., & Tabakoff, B. (1998). Effects of abstinence and family history for alcoholism on platelet adenylyl cyclase activity. Alcoholism, Clinical and Experimental Research, 22(9), 1955-61.
Menninger JA, Barón AE, Tabakoff B. Effects of Abstinence and Family History for Alcoholism On Platelet Adenylyl Cyclase Activity. Alcohol Clin Exp Res. 1998;22(9):1955-61. PubMed PMID: 9884138.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of abstinence and family history for alcoholism on platelet adenylyl cyclase activity. AU - Menninger,J A, AU - Barón,A E, AU - Tabakoff,B, PY - 1999/1/12/pubmed PY - 1999/1/12/medline PY - 1999/1/12/entrez SP - 1955 EP - 61 JF - Alcoholism, clinical and experimental research JO - Alcohol Clin Exp Res VL - 22 IS - 9 N2 - Platelet adenylyl cyclase (AC) activity was measured in 32 alcohol-dependent subjects and 27 control subjects who were categorized as either family history-positive (FHP) or family history-negative (FHN) for alcoholism. The interview and blood sample collections were performed shortly after cessation of heavy drinking in the alcoholic group, and repeat blood samples were obtained at the end of the first and second weeks of monitored abstinence. Control subjects received the same interview and provided blood samples at the time of the interview. When subjects were not segregated for FHP or FHN status, there were no statistically significant differences in basal, cesium fluoride (CsF)-, or forskolin-stimulated mean AC activities between the controls and the alcoholics, at study entry or with 1 or 2 weeks of abstinence. On the other hand, over the 2-week course of sobriety from heavy drinking, the CsF-stimulated AC activity of FHP alcohol-dependent subjects decreased significantly (p = 0.03). FHP alcohol-dependent subjects after 2 weeks of sobriety had significantly lower mean CsF-stimulated AC activity than FHN controls (p = 0.04), whereas the FHN alcoholic subjects' CsF-stimulated AC activity did not differ significantly from FHN controls at this point in time. When all subjects were pooled and then categorized as either FHP or FHN, there was a significant difference in mean CsF-stimulated AC activity (p = 0.02) between the FHP and FHN subject groups. Genetic factors and abstinence appear to have roles in determining low platelet AC activity in alcoholic and nonalcoholic subjects. CsF-stimulated platelet AC activity, in particular, appears to act as a trait marker for a genetic vulnerability to developing alcoholism, but recent heavy drinking in male alcoholics is a factor that can mask differences between FHP and FHN subjects. SN - 0145-6008 UR - https://www.unboundmedicine.com/medline/citation/9884138/Effects_of_abstinence_and_family_history_for_alcoholism_on_platelet_adenylyl_cyclase_activity_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0145-6008&date=1998&volume=22&issue=9&spage=1955 DB - PRIME DP - Unbound Medicine ER -