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The effects of substituting zopiclone in withdrawal from chronic use of benzodiazepine hypnotics.

Abstract

Twenty-four volunteers (19 women and five men) with insomnia and a history of chronic use of benzodiazepine hypnotics participated in a randomized, double blind, controlled clinical trial. The study was designed to assess the effects of substituting zopiclone (ZOP)- as an hypnotic- among chronic users of flunitrazepam (FLU), and to compare the subsequent withdrawal of ZOP with placebo controlled withdrawal of FLU. During the 5 weeks of a withdrawal protocol, sleep and physiological parameters were assessed by polysomnographic measures for 11 nights and by nightly actigraphic recordings for weeks 1, 3, and 5. Subjective effects of the withdrawal process were evaluated with daily sleep diaries, and with various weekly self-report symptom checklists. Paired t-tests performed on differences in objective sleep parameters between baseline and the last weeks of the withdrawal program showed a significant decrease in sleep quality within the FLU group, but not in the ZOP group. Subjective sleep diaries consistently reflected the objectively measured changes in sleep throughout the withdrawal program, indicating significant changes in sleep parameters only in the FLU group. The results obtained from the self report inventories aimed at assessing withdrawal symptoms, however, revealed no differences between the baseline week and the termination week of the program in any of the groups. After completing the pharmacological withdrawal, all subjects received a short-term cognitive behavioral intervention focused on improving their coping strategies with symptoms of insomnia; they were evaluated immediately after concluding the intervention, and at 3 and 12 month follow- ups.

Authors+Show Affiliations

,

Technion Sleep Laboratory, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.

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Source

Psychopharmacology 140:4 1998 Dec pg 450-7

MeSH

Adult
Anti-Anxiety Agents
Azabicyclo Compounds
Double-Blind Method
Female
Flunitrazepam
Follow-Up Studies
Humans
Hypnotics and Sedatives
Male
Middle Aged
Motor Activity
Piperazines
Polysomnography
Sleep
Sleep Initiation and Maintenance Disorders
Substance Withdrawal Syndrome

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9888621

Citation

Pat-Horenczyk, R, et al. "The Effects of Substituting Zopiclone in Withdrawal From Chronic Use of Benzodiazepine Hypnotics." Psychopharmacology, vol. 140, no. 4, 1998, pp. 450-7.
Pat-Horenczyk R, Hacohen D, Herer P, et al. The effects of substituting zopiclone in withdrawal from chronic use of benzodiazepine hypnotics. Psychopharmacology (Berl). 1998;140(4):450-7.
Pat-Horenczyk, R., Hacohen, D., Herer, P., & Lavie, P. (1998). The effects of substituting zopiclone in withdrawal from chronic use of benzodiazepine hypnotics. Psychopharmacology, 140(4), pp. 450-7.
Pat-Horenczyk R, et al. The Effects of Substituting Zopiclone in Withdrawal From Chronic Use of Benzodiazepine Hypnotics. Psychopharmacology (Berl). 1998;140(4):450-7. PubMed PMID: 9888621.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of substituting zopiclone in withdrawal from chronic use of benzodiazepine hypnotics. AU - Pat-Horenczyk,R, AU - Hacohen,D, AU - Herer,P, AU - Lavie,P, PY - 1999/1/15/pubmed PY - 1999/1/15/medline PY - 1999/1/15/entrez SP - 450 EP - 7 JF - Psychopharmacology JO - Psychopharmacology (Berl.) VL - 140 IS - 4 N2 - Twenty-four volunteers (19 women and five men) with insomnia and a history of chronic use of benzodiazepine hypnotics participated in a randomized, double blind, controlled clinical trial. The study was designed to assess the effects of substituting zopiclone (ZOP)- as an hypnotic- among chronic users of flunitrazepam (FLU), and to compare the subsequent withdrawal of ZOP with placebo controlled withdrawal of FLU. During the 5 weeks of a withdrawal protocol, sleep and physiological parameters were assessed by polysomnographic measures for 11 nights and by nightly actigraphic recordings for weeks 1, 3, and 5. Subjective effects of the withdrawal process were evaluated with daily sleep diaries, and with various weekly self-report symptom checklists. Paired t-tests performed on differences in objective sleep parameters between baseline and the last weeks of the withdrawal program showed a significant decrease in sleep quality within the FLU group, but not in the ZOP group. Subjective sleep diaries consistently reflected the objectively measured changes in sleep throughout the withdrawal program, indicating significant changes in sleep parameters only in the FLU group. The results obtained from the self report inventories aimed at assessing withdrawal symptoms, however, revealed no differences between the baseline week and the termination week of the program in any of the groups. After completing the pharmacological withdrawal, all subjects received a short-term cognitive behavioral intervention focused on improving their coping strategies with symptoms of insomnia; they were evaluated immediately after concluding the intervention, and at 3 and 12 month follow- ups. SN - 0033-3158 UR - https://www.unboundmedicine.com/medline/citation/9888621/The_effects_of_substituting_zopiclone_in_withdrawal_from_chronic_use_of_benzodiazepine_hypnotics_ DB - PRIME DP - Unbound Medicine ER -