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Delta9-THC training dose as a determinant for (R)-methanandamide generalization in rats.
Psychopharmacology (Berl). 1998 Dec; 140(4):519-22.P

Abstract

The objective of this study was to examine if (R)-methanandamide, a metabolically stable chiral analog of the endogenous ligand anandamide, is a cannabimimetic with a lower efficacy than delta9-THC. Employing a two-lever choice drug discrimination procedure, rats were trained to discriminate between 1.8, 3.0, or 5.6 mg/kg delta9-tetrahydrocannabinol (delta9-THC) and vehicle. Different training doses were used in order to create assays with different efficacy demands. Generalization tests with 18 mg/kg (R)-methanandamide yielded around 90% delta9-THC responses in the two lower delta9-THC training dose conditions. However, only around 60% delta9-THC responses occurred in the 5.6 mg/kg delta9-THC training dose condition in tests with 18 mg/kg (R)-methanandamide; a higher dose (30 mg/kg) produced even fewer delta9-THC-appropriate responses in this group. Morphine did not substitute for delta9-THC. In conclusion, the data with delta9-THC and (R)-methanandamide indicate that cannabinoid agonists can have varying degrees of intrinsic activity at a receptor site, or may produce their behavioral actions through multiple mechanisms, or both.

Authors+Show Affiliations

Allegheny University of the Health Sciences, Institute of Addictive Disorders, Department of Psychiatry, Philadelphia, PA 19102, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9888629

Citation

Järbe, T U., et al. "Delta9-THC Training Dose as a Determinant for (R)-methanandamide Generalization in Rats." Psychopharmacology, vol. 140, no. 4, 1998, pp. 519-22.
Järbe TU, Lamb RJ, Makriyannis A, et al. Delta9-THC training dose as a determinant for (R)-methanandamide generalization in rats. Psychopharmacology (Berl). 1998;140(4):519-22.
Järbe, T. U., Lamb, R. J., Makriyannis, A., Lin, S., & Goutopoulos, A. (1998). Delta9-THC training dose as a determinant for (R)-methanandamide generalization in rats. Psychopharmacology, 140(4), 519-22.
Järbe TU, et al. Delta9-THC Training Dose as a Determinant for (R)-methanandamide Generalization in Rats. Psychopharmacology (Berl). 1998;140(4):519-22. PubMed PMID: 9888629.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Delta9-THC training dose as a determinant for (R)-methanandamide generalization in rats. AU - Järbe,T U, AU - Lamb,R J, AU - Makriyannis,A, AU - Lin,S, AU - Goutopoulos,A, PY - 1999/1/15/pubmed PY - 1999/1/15/medline PY - 1999/1/15/entrez SP - 519 EP - 22 JF - Psychopharmacology JO - Psychopharmacology (Berl) VL - 140 IS - 4 N2 - The objective of this study was to examine if (R)-methanandamide, a metabolically stable chiral analog of the endogenous ligand anandamide, is a cannabimimetic with a lower efficacy than delta9-THC. Employing a two-lever choice drug discrimination procedure, rats were trained to discriminate between 1.8, 3.0, or 5.6 mg/kg delta9-tetrahydrocannabinol (delta9-THC) and vehicle. Different training doses were used in order to create assays with different efficacy demands. Generalization tests with 18 mg/kg (R)-methanandamide yielded around 90% delta9-THC responses in the two lower delta9-THC training dose conditions. However, only around 60% delta9-THC responses occurred in the 5.6 mg/kg delta9-THC training dose condition in tests with 18 mg/kg (R)-methanandamide; a higher dose (30 mg/kg) produced even fewer delta9-THC-appropriate responses in this group. Morphine did not substitute for delta9-THC. In conclusion, the data with delta9-THC and (R)-methanandamide indicate that cannabinoid agonists can have varying degrees of intrinsic activity at a receptor site, or may produce their behavioral actions through multiple mechanisms, or both. SN - 0033-3158 UR - https://www.unboundmedicine.com/medline/citation/9888629/Delta9_THC_training_dose_as_a_determinant_for__R__methanandamide_generalization_in_rats_ L2 - https://dx.doi.org/10.1007/s002130050797 DB - PRIME DP - Unbound Medicine ER -