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Detection of serum antibodies against cytomegalovirus, varicella zoster virus and human herpesvirus 6 in patients with recurrent aphthous stomatitis.
J Oral Pathol Med. 1999 Jan; 28(1):12-5.JO

Abstract

There has recently been renewed interest in the possible role of viruses in recurrent aphthous stomatitis (RAS). In this study, sera from 22 patients with RAS, 24 patients with oral lichen planus (OLP) and 15 healthy controls were screened for IgG and IgM class antibodies to human cytomegalovirus (HCMV), varicella zoster virus (VZV) and human herpesvirus 6 (HHV-6). Commercially available ELISA and immunofluorescence kits were employed. There were no significant differences in the prevalence of IgG antibodies to HCMV, VZV or HHV-6 among the three patient groups. Similarly, there were no significant differences between the prevalence of HCMV and VZV IgM antibodies among RAS patients and controls. However, specific HHV-6 IgM was detected in 21 (95%) of the RAS patients and 17 (71%) of the lichen planus patients compared with 8 (53%) of the healthy controls. This difference between RAS patients and controls was statistically significant (P<0.01). These results do not support an aetiological role for HCMV or VZV in RAS but suggest possible involvement of HHV-6.

Authors+Show Affiliations

Glasgow Dental Hospital & School NHS Trust, Scotland.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

9890451

Citation

Ghodratnama, F, et al. "Detection of Serum Antibodies Against Cytomegalovirus, Varicella Zoster Virus and Human Herpesvirus 6 in Patients With Recurrent Aphthous Stomatitis." Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, vol. 28, no. 1, 1999, pp. 12-5.
Ghodratnama F, Wray D, Bagg J. Detection of serum antibodies against cytomegalovirus, varicella zoster virus and human herpesvirus 6 in patients with recurrent aphthous stomatitis. J Oral Pathol Med. 1999;28(1):12-5.
Ghodratnama, F., Wray, D., & Bagg, J. (1999). Detection of serum antibodies against cytomegalovirus, varicella zoster virus and human herpesvirus 6 in patients with recurrent aphthous stomatitis. Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 28(1), 12-5.
Ghodratnama F, Wray D, Bagg J. Detection of Serum Antibodies Against Cytomegalovirus, Varicella Zoster Virus and Human Herpesvirus 6 in Patients With Recurrent Aphthous Stomatitis. J Oral Pathol Med. 1999;28(1):12-5. PubMed PMID: 9890451.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection of serum antibodies against cytomegalovirus, varicella zoster virus and human herpesvirus 6 in patients with recurrent aphthous stomatitis. AU - Ghodratnama,F, AU - Wray,D, AU - Bagg,J, PY - 1999/1/16/pubmed PY - 1999/1/16/medline PY - 1999/1/16/entrez SP - 12 EP - 5 JF - Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology JO - J. Oral Pathol. Med. VL - 28 IS - 1 N2 - There has recently been renewed interest in the possible role of viruses in recurrent aphthous stomatitis (RAS). In this study, sera from 22 patients with RAS, 24 patients with oral lichen planus (OLP) and 15 healthy controls were screened for IgG and IgM class antibodies to human cytomegalovirus (HCMV), varicella zoster virus (VZV) and human herpesvirus 6 (HHV-6). Commercially available ELISA and immunofluorescence kits were employed. There were no significant differences in the prevalence of IgG antibodies to HCMV, VZV or HHV-6 among the three patient groups. Similarly, there were no significant differences between the prevalence of HCMV and VZV IgM antibodies among RAS patients and controls. However, specific HHV-6 IgM was detected in 21 (95%) of the RAS patients and 17 (71%) of the lichen planus patients compared with 8 (53%) of the healthy controls. This difference between RAS patients and controls was statistically significant (P<0.01). These results do not support an aetiological role for HCMV or VZV in RAS but suggest possible involvement of HHV-6. SN - 0904-2512 UR - https://www.unboundmedicine.com/medline/citation/9890451/Detection_of_serum_antibodies_against_cytomegalovirus_varicella_zoster_virus_and_human_herpesvirus_6_in_patients_with_recurrent_aphthous_stomatitis_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0904-2512&amp;date=1999&amp;volume=28&amp;issue=1&amp;spage=12 DB - PRIME DP - Unbound Medicine ER -