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Oral lichen planus in patients infected or noninfected with hepatitis C virus: the role of autoimmunity.
J Oral Pathol Med. 1999 Jan; 28(1):16-9.JO

Abstract

Serum proteins, serum immunoglobulins, anti-nuclear antibodies (ANA), anti-smooth muscle antibodies (ASMA), anti-mitochondrial antibodies (AMA), anti-liver-kidney antibodies (LKM), anti-parietal-cell gastric antibodies (APCA), anti-epithelial antibodies and concomitant autoimmune disease were studied in 27 OLP-HCV+ve subjects and in a comparable group of 23 who were OLP-HCV-ve. In addition, all the patients with chronic liver disease who were sero-positive for ANA, AMA or LKM were scored using the new aggregate scoring system to detect those with the accepted criteria for the diagnosis of autoimmune hepatitis (AIH). Hypergammaglobulinemia was more frequent in OLP-HCV+ve than in OLP-HCV-ve (P = 0.008) subjects. Serum IgG and IgM levels were higher in HCV+ve than in HCV-ve (respectively, P = 0.017 and P = 0.018) individuals. However, there was no difference in the frequency of any autoantibody between OLP-HCV+ve and OLP-HCV-ve patients. Overall, immunologically-related abnormalities were found in 17(63%) OLP-HCV+ve and 11(48%) OLP-HCV-ve (P = 0.43) patients. Three OLP-HCV-ve and no OLP-HCV+ve patients had score criteria of probable AIH. The present and our previous data suggest that OLP patients with HCV infection neither had evidence of autoimmune liver damage nor had abnormal humoral immune-responses, with the exception of higher than control levels of serum immunoglobulins. Cryoglobulins may be responsible.

Authors+Show Affiliations

Department of Oral Medicine and Periodontology, School of Medicine and Dentistry, University of Turin, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

9890452

Citation

Carrozzo, M, et al. "Oral Lichen Planus in Patients Infected or Noninfected With Hepatitis C Virus: the Role of Autoimmunity." Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, vol. 28, no. 1, 1999, pp. 16-9.
Carrozzo M, Gandolfo S, Lodi G, et al. Oral lichen planus in patients infected or noninfected with hepatitis C virus: the role of autoimmunity. J Oral Pathol Med. 1999;28(1):16-9.
Carrozzo, M., Gandolfo, S., Lodi, G., Carbone, M., Garzino-Demo, P., Carbonero, C., Porter, S. R., & Scully, C. (1999). Oral lichen planus in patients infected or noninfected with hepatitis C virus: the role of autoimmunity. Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 28(1), 16-9.
Carrozzo M, et al. Oral Lichen Planus in Patients Infected or Noninfected With Hepatitis C Virus: the Role of Autoimmunity. J Oral Pathol Med. 1999;28(1):16-9. PubMed PMID: 9890452.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral lichen planus in patients infected or noninfected with hepatitis C virus: the role of autoimmunity. AU - Carrozzo,M, AU - Gandolfo,S, AU - Lodi,G, AU - Carbone,M, AU - Garzino-Demo,P, AU - Carbonero,C, AU - Porter,S R, AU - Scully,C, PY - 1999/1/16/pubmed PY - 1999/1/16/medline PY - 1999/1/16/entrez SP - 16 EP - 9 JF - Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology JO - J Oral Pathol Med VL - 28 IS - 1 N2 - Serum proteins, serum immunoglobulins, anti-nuclear antibodies (ANA), anti-smooth muscle antibodies (ASMA), anti-mitochondrial antibodies (AMA), anti-liver-kidney antibodies (LKM), anti-parietal-cell gastric antibodies (APCA), anti-epithelial antibodies and concomitant autoimmune disease were studied in 27 OLP-HCV+ve subjects and in a comparable group of 23 who were OLP-HCV-ve. In addition, all the patients with chronic liver disease who were sero-positive for ANA, AMA or LKM were scored using the new aggregate scoring system to detect those with the accepted criteria for the diagnosis of autoimmune hepatitis (AIH). Hypergammaglobulinemia was more frequent in OLP-HCV+ve than in OLP-HCV-ve (P = 0.008) subjects. Serum IgG and IgM levels were higher in HCV+ve than in HCV-ve (respectively, P = 0.017 and P = 0.018) individuals. However, there was no difference in the frequency of any autoantibody between OLP-HCV+ve and OLP-HCV-ve patients. Overall, immunologically-related abnormalities were found in 17(63%) OLP-HCV+ve and 11(48%) OLP-HCV-ve (P = 0.43) patients. Three OLP-HCV-ve and no OLP-HCV+ve patients had score criteria of probable AIH. The present and our previous data suggest that OLP patients with HCV infection neither had evidence of autoimmune liver damage nor had abnormal humoral immune-responses, with the exception of higher than control levels of serum immunoglobulins. Cryoglobulins may be responsible. SN - 0904-2512 UR - https://www.unboundmedicine.com/medline/citation/9890452/Oral_lichen_planus_in_patients_infected_or_noninfected_with_hepatitis_C_virus:_the_role_of_autoimmunity_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0904-2512&date=1999&volume=28&issue=1&spage=16 DB - PRIME DP - Unbound Medicine ER -