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The influence of rutin on the weight, metastasis and melanin content of B16 melanotic melanoma in C57BL/6 mice.
Neoplasma. 1998; 45(4):266-71.N

Abstract

The influence of rutin on the growth rate and tumor weight of B16 melanoma as well as melanin content and ultrastructure of melanoma cells and metastasis formation was studied in mice. All mice were injected s.c. into the left flank with 0.2 ml of suspension containing 10(6) B16 melanoma cells. The experimental groups were treated with a solution of rutin i.p. every two days with total doses of 1, 5 or 10 mg/mouse. The rutin was dissolved in DMSO. The control groups of mice were injected with 0.2 ml 0.9% NaCl and 0.2 ml DMSO. Increasing doses of rutin 1, 5 or 10 mg per mouse caused augmentation of the tumor mass to 2400 mg, 2600 mg and 2800 mg respectively, whereas the tumor weight of the control group was 980 mg. The median number of lung metastases in the control groups was 12; after treatment with 5 or 10 mg of rutin, the number of lung colonies increased to 19 and 27, respectively. The administration of 10 mg rutin inhibited melanin formation by about 43%. The melanosomes in the experimental groups were in the 2nd or 3rd stage, and the low content of melanin was noticed.

Authors+Show Affiliations

Department of Human Biology, University School of Medical Science, Bydgoszcz, Poland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9890672

Citation

Drewa, G, et al. "The Influence of Rutin On the Weight, Metastasis and Melanin Content of B16 Melanotic Melanoma in C57BL/6 Mice." Neoplasma, vol. 45, no. 4, 1998, pp. 266-71.
Drewa G, Schachtschabel DO, Pałgan K, et al. The influence of rutin on the weight, metastasis and melanin content of B16 melanotic melanoma in C57BL/6 mice. Neoplasma. 1998;45(4):266-71.
Drewa, G., Schachtschabel, D. O., Pałgan, K., Grzanka, A., & Sujkowska, R. (1998). The influence of rutin on the weight, metastasis and melanin content of B16 melanotic melanoma in C57BL/6 mice. Neoplasma, 45(4), 266-71.
Drewa G, et al. The Influence of Rutin On the Weight, Metastasis and Melanin Content of B16 Melanotic Melanoma in C57BL/6 Mice. Neoplasma. 1998;45(4):266-71. PubMed PMID: 9890672.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The influence of rutin on the weight, metastasis and melanin content of B16 melanotic melanoma in C57BL/6 mice. AU - Drewa,G, AU - Schachtschabel,D O, AU - Pałgan,K, AU - Grzanka,A, AU - Sujkowska,R, PY - 1999/1/16/pubmed PY - 1999/1/16/medline PY - 1999/1/16/entrez SP - 266 EP - 71 JF - Neoplasma JO - Neoplasma VL - 45 IS - 4 N2 - The influence of rutin on the growth rate and tumor weight of B16 melanoma as well as melanin content and ultrastructure of melanoma cells and metastasis formation was studied in mice. All mice were injected s.c. into the left flank with 0.2 ml of suspension containing 10(6) B16 melanoma cells. The experimental groups were treated with a solution of rutin i.p. every two days with total doses of 1, 5 or 10 mg/mouse. The rutin was dissolved in DMSO. The control groups of mice were injected with 0.2 ml 0.9% NaCl and 0.2 ml DMSO. Increasing doses of rutin 1, 5 or 10 mg per mouse caused augmentation of the tumor mass to 2400 mg, 2600 mg and 2800 mg respectively, whereas the tumor weight of the control group was 980 mg. The median number of lung metastases in the control groups was 12; after treatment with 5 or 10 mg of rutin, the number of lung colonies increased to 19 and 27, respectively. The administration of 10 mg rutin inhibited melanin formation by about 43%. The melanosomes in the experimental groups were in the 2nd or 3rd stage, and the low content of melanin was noticed. SN - 0028-2685 UR - https://www.unboundmedicine.com/medline/citation/9890672/The_influence_of_rutin_on_the_weight_metastasis_and_melanin_content_of_B16_melanotic_melanoma_in_C57BL/6_mice_ L2 - https://medlineplus.gov/lungcancer.html DB - PRIME DP - Unbound Medicine ER -