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Prospective study of risk factors for Alzheimer's disease: results at 7.5 years.
Am J Psychiatry. 1999 Jan; 156(1):50-7.AJ

Abstract

OBJECTIVE

The primary goal of this study was to evaluate increased platelet membrane fluidity as a putative risk factor for Alzheimer's disease and its relationship to the APOE epsilon4 genotype.

METHOD

This report describes the results of a prospective, longitudinal study of 330 initially asymptomatic, first-degree relatives of probands with Alzheimer's disease.

RESULTS

Nine incident cases of Alzheimer's disease were detected during the first 2,220 subject-years of the follow-up period. Age, increased platelet membrane fluidity, and the APOE epsilon4 allele made significant independent contributions to the risk of developing Alzheimer's disease, while sex and years of education did not. Increased platelet membrane fluidity was associated with incident Alzheimer's disease cases between the ages of 64 and 71, while the epsilon4 allele was associated with incident Alzheimer's disease cases from age 64 until at least age 80.

CONCLUSIONS

These results indicate that increased platelet membrane fluidity is not produced by the APOE epsilon4 allele. Instead, increased platelet membrane fluidity and the epsilon4 allele appear to make significant independent contributions to the risk of developing Alzheimer's disease among the first-degree relatives of patients with this disorder. Moreover, the age ranges over which these risk factors operate appear to be different.

Authors+Show Affiliations

Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9892297

Citation

Zubenko, G S., et al. "Prospective Study of Risk Factors for Alzheimer's Disease: Results at 7.5 Years." The American Journal of Psychiatry, vol. 156, no. 1, 1999, pp. 50-7.
Zubenko GS, Winwood E, Jacobs B, et al. Prospective study of risk factors for Alzheimer's disease: results at 7.5 years. Am J Psychiatry. 1999;156(1):50-7.
Zubenko, G. S., Winwood, E., Jacobs, B., Teply, I., Stiffler, J. S., Hughes, H. B., Huff, F. J., Sunderland, T., & Martinez, A. J. (1999). Prospective study of risk factors for Alzheimer's disease: results at 7.5 years. The American Journal of Psychiatry, 156(1), 50-7.
Zubenko GS, et al. Prospective Study of Risk Factors for Alzheimer's Disease: Results at 7.5 Years. Am J Psychiatry. 1999;156(1):50-7. PubMed PMID: 9892297.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospective study of risk factors for Alzheimer's disease: results at 7.5 years. AU - Zubenko,G S, AU - Winwood,E, AU - Jacobs,B, AU - Teply,I, AU - Stiffler,J S, AU - Hughes,H B,3rd AU - Huff,F J, AU - Sunderland,T, AU - Martinez,A J, PY - 1999/1/19/pubmed PY - 2001/3/28/medline PY - 1999/1/19/entrez SP - 50 EP - 7 JF - The American journal of psychiatry JO - Am J Psychiatry VL - 156 IS - 1 N2 - OBJECTIVE: The primary goal of this study was to evaluate increased platelet membrane fluidity as a putative risk factor for Alzheimer's disease and its relationship to the APOE epsilon4 genotype. METHOD: This report describes the results of a prospective, longitudinal study of 330 initially asymptomatic, first-degree relatives of probands with Alzheimer's disease. RESULTS: Nine incident cases of Alzheimer's disease were detected during the first 2,220 subject-years of the follow-up period. Age, increased platelet membrane fluidity, and the APOE epsilon4 allele made significant independent contributions to the risk of developing Alzheimer's disease, while sex and years of education did not. Increased platelet membrane fluidity was associated with incident Alzheimer's disease cases between the ages of 64 and 71, while the epsilon4 allele was associated with incident Alzheimer's disease cases from age 64 until at least age 80. CONCLUSIONS: These results indicate that increased platelet membrane fluidity is not produced by the APOE epsilon4 allele. Instead, increased platelet membrane fluidity and the epsilon4 allele appear to make significant independent contributions to the risk of developing Alzheimer's disease among the first-degree relatives of patients with this disorder. Moreover, the age ranges over which these risk factors operate appear to be different. SN - 0002-953X UR - https://www.unboundmedicine.com/medline/citation/9892297/Prospective_study_of_risk_factors_for_Alzheimer's_disease:_results_at_7_5_years_ L2 - https://ajp.psychiatryonline.org/doi/full/10.1176/ajp.156.1.50?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -