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The protective effect of moderate alcohol consumption on ischemic stroke.

Abstract

CONTEXT

Moderate alcohol consumption has been shown to be protective for coronary heart disease, but the relationship between moderate alcohol consumption and ischemic stroke is more controversial.

OBJECTIVE

To determine the association between alcohol consumption and risk of ischemic stroke.

DESIGN

Population-based case-control study conducted between July 1993 and June 1997.

SETTING

Multiethnic population in northern Manhattan, New York, NY, aged 40 years or older.

PATIENTS AND OTHER PARTICIPANTS

Cases (n = 677) had first ischemic stroke and were matched to community controls (n = 1139) derived through random digit dialing by age, sex, and race/ethnicity. Mean +/- SD age of cases was 70.0+/-12.7 years; 55.8% were women; 19.5% were white, 28.4% black, and 50.7% Hispanic.

MAIN OUTCOME MEASURE

First ischemic stroke (fatal or nonfatal).

RESULTS

Moderate alcohol consumption, up to 2 drinks per day, was significantly protective for ischemic stroke after adjustment for cardiac disease, hypertension, diabetes, current smoking, body mass index, and education (odds ratio [OR], 0.51; 95% confidence interval [CI], 0.39-0.67). This protective effect of alcohol consumption was detected in both younger and older groups, in men and women, and in whites, blacks, and Hispanics. In a quadratic model of stroke risk, increased risk of ischemic stroke was statistically significant among those consuming 7 or more drinks per day (OR, 2.96; 95% CI, 1.05-8.29).

CONCLUSIONS

Moderate alcohol consumption was independently associated with a decreased risk of ischemic stroke in our elderly, multiethnic, urban subjects, while heavy alcohol consumption had deleterious effects. Our data support the National Stroke Association Stroke Prevention Guidelines regarding the beneficial effects of moderate alcohol consumption.

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  • Authors+Show Affiliations

    ,

    Department of Neurology, Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY, USA. rls1@columbia.edu

    , , , , , ,

    Source

    JAMA 281:1 1999 Jan 06 pg 53-60

    MeSH

    Adult
    African Americans
    Aged
    Alcohol Drinking
    Brain Ischemia
    Case-Control Studies
    Cerebrovascular Disorders
    European Continental Ancestry Group
    Female
    Hispanic Americans
    Humans
    Male
    Middle Aged
    New York City
    Practice Guidelines as Topic
    Risk
    Statistics as Topic

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    9892451

    Citation

    Sacco, R L., et al. "The Protective Effect of Moderate Alcohol Consumption On Ischemic Stroke." JAMA, vol. 281, no. 1, 1999, pp. 53-60.
    Sacco RL, Elkind M, Boden-Albala B, et al. The protective effect of moderate alcohol consumption on ischemic stroke. JAMA. 1999;281(1):53-60.
    Sacco, R. L., Elkind, M., Boden-Albala, B., Lin, I. F., Kargman, D. E., Hauser, W. A., ... Paik, M. C. (1999). The protective effect of moderate alcohol consumption on ischemic stroke. JAMA, 281(1), pp. 53-60.
    Sacco RL, et al. The Protective Effect of Moderate Alcohol Consumption On Ischemic Stroke. JAMA. 1999 Jan 6;281(1):53-60. PubMed PMID: 9892451.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The protective effect of moderate alcohol consumption on ischemic stroke. AU - Sacco,R L, AU - Elkind,M, AU - Boden-Albala,B, AU - Lin,I F, AU - Kargman,D E, AU - Hauser,W A, AU - Shea,S, AU - Paik,M C, PY - 1999/1/19/pubmed PY - 2001/8/14/medline PY - 1999/1/19/entrez SP - 53 EP - 60 JF - JAMA JO - JAMA VL - 281 IS - 1 N2 - CONTEXT: Moderate alcohol consumption has been shown to be protective for coronary heart disease, but the relationship between moderate alcohol consumption and ischemic stroke is more controversial. OBJECTIVE: To determine the association between alcohol consumption and risk of ischemic stroke. DESIGN: Population-based case-control study conducted between July 1993 and June 1997. SETTING: Multiethnic population in northern Manhattan, New York, NY, aged 40 years or older. PATIENTS AND OTHER PARTICIPANTS: Cases (n = 677) had first ischemic stroke and were matched to community controls (n = 1139) derived through random digit dialing by age, sex, and race/ethnicity. Mean +/- SD age of cases was 70.0+/-12.7 years; 55.8% were women; 19.5% were white, 28.4% black, and 50.7% Hispanic. MAIN OUTCOME MEASURE: First ischemic stroke (fatal or nonfatal). RESULTS: Moderate alcohol consumption, up to 2 drinks per day, was significantly protective for ischemic stroke after adjustment for cardiac disease, hypertension, diabetes, current smoking, body mass index, and education (odds ratio [OR], 0.51; 95% confidence interval [CI], 0.39-0.67). This protective effect of alcohol consumption was detected in both younger and older groups, in men and women, and in whites, blacks, and Hispanics. In a quadratic model of stroke risk, increased risk of ischemic stroke was statistically significant among those consuming 7 or more drinks per day (OR, 2.96; 95% CI, 1.05-8.29). CONCLUSIONS: Moderate alcohol consumption was independently associated with a decreased risk of ischemic stroke in our elderly, multiethnic, urban subjects, while heavy alcohol consumption had deleterious effects. Our data support the National Stroke Association Stroke Prevention Guidelines regarding the beneficial effects of moderate alcohol consumption. SN - 0098-7484 UR - https://www.unboundmedicine.com/medline/citation/9892451/The_protective_effect_of_moderate_alcohol_consumption_on_ischemic_stroke_ L2 - https://jamanetwork.com/journals/jama/fullarticle/vol/281/pg/53 DB - PRIME DP - Unbound Medicine ER -