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Steroid receptors at the nexus of transcriptional regulation.
J Cell Biochem Suppl. 1998; 30-31:185-93.JC

Abstract

During the past few years, our understanding of nuclear receptor action has dramatically improved as a result of the identification and functional analysis of co-regulators such as factors involved in chromatin remodeling, transcription intermediary factors (co-repressors and co-activators), and direct interactions with the basal transcriptional machinery. Furthermore, the elucidation of the crystal structures of the empty ligand-binding domains of the nuclear receptor and of complexes formed by the nuclear receptor's ligand-binding domain bound to agonists and antagonists has contributed significantly to our understanding of the early events of nuclear receptor action. However, the picture of hormone- and hormone receptor-mediated mechanisms of gene regulation remain incomplete and extremely complicated when one also considers the "nontraditional" interactions of hormone-activated nuclear receptors, for example, interactions between the activated steroid receptors and components of the chromatin/nuclear matrix; and finally the nongenomic effects that steroid hormones can exhibit with other signaling pathways. In this prospectus on steroid receptors, we discuss the implications of various steroid hormone and nuclear receptor interactions and potential future directions of investigation.

Authors+Show Affiliations

Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

9893270

Citation

Barrett, T J., and T C. Spelsberg. "Steroid Receptors at the Nexus of Transcriptional Regulation." Journal of Cellular Biochemistry. Supplement, vol. 30-31, 1998, pp. 185-93.
Barrett TJ, Spelsberg TC. Steroid receptors at the nexus of transcriptional regulation. J Cell Biochem Suppl. 1998;30-31:185-93.
Barrett, T. J., & Spelsberg, T. C. (1998). Steroid receptors at the nexus of transcriptional regulation. Journal of Cellular Biochemistry. Supplement, 30-31, 185-93.
Barrett TJ, Spelsberg TC. Steroid Receptors at the Nexus of Transcriptional Regulation. J Cell Biochem Suppl. 1998;30-31:185-93. PubMed PMID: 9893270.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Steroid receptors at the nexus of transcriptional regulation. AU - Barrett,T J, AU - Spelsberg,T C, PY - 1999/1/20/pubmed PY - 1999/1/20/medline PY - 1999/1/20/entrez SP - 185 EP - 93 JF - Journal of cellular biochemistry. Supplement JO - J Cell Biochem Suppl VL - 30-31 N2 - During the past few years, our understanding of nuclear receptor action has dramatically improved as a result of the identification and functional analysis of co-regulators such as factors involved in chromatin remodeling, transcription intermediary factors (co-repressors and co-activators), and direct interactions with the basal transcriptional machinery. Furthermore, the elucidation of the crystal structures of the empty ligand-binding domains of the nuclear receptor and of complexes formed by the nuclear receptor's ligand-binding domain bound to agonists and antagonists has contributed significantly to our understanding of the early events of nuclear receptor action. However, the picture of hormone- and hormone receptor-mediated mechanisms of gene regulation remain incomplete and extremely complicated when one also considers the "nontraditional" interactions of hormone-activated nuclear receptors, for example, interactions between the activated steroid receptors and components of the chromatin/nuclear matrix; and finally the nongenomic effects that steroid hormones can exhibit with other signaling pathways. In this prospectus on steroid receptors, we discuss the implications of various steroid hormone and nuclear receptor interactions and potential future directions of investigation. SN - 0733-1959 UR - https://www.unboundmedicine.com/medline/citation/9893270/Steroid_receptors_at_the_nexus_of_transcriptional_regulation_ DB - PRIME DP - Unbound Medicine ER -
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