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A quantitative study of neurofibrillary tangles, senile plaques and astrocytes in the hippocampal subdivisions and entorhinal cortex in Alzheimer's disease, normal controls and non-Alzheimer neuropsychiatric diseases.
Psychiatry Clin Neurosci. 1998 Dec; 52(6):593-9.PC

Abstract

The present quantitative study was performed in order to discriminate pathological substrates for dementia from Alzheimer changes in normal controls (NC) and non-Alzheimer neuropsychiatric diseases (NAND). Regional densities of senile plaques (SP), neurofibrillary tangles (NFT) and astrocytes in the cornu ammonis (CA), subiculum and entorhinal cortex were measured and differences in these densities among Alzheimer's disease (AD), NAND and NC were statistically compared. Densities of NFT in the CA and subiculum were significantly higher in AD than in NAND, and densities of SP in all regions were significantly higher in AD than in NAND. Similarly, NFT density in the subiculum and SP density in all regions were higher in AD than in NC. Regional densities of astrocytes in most regions were closely correlated with those of Alzheimer changes. In conclusion, the attribution of the Alzheimer changes, particularly of NFT, to dementia is neglected when they are confined to the entorhinal cortex. However, the attribution of the Alzheimer changes to dementia should be appreciated when they spread from the entorhinal cortex to the subiculum and/or CA.

Authors+Show Affiliations

Department of Neuropsychiatry, Kanazawa University School of Medicine, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9895207

Citation

Muramori, F, et al. "A Quantitative Study of Neurofibrillary Tangles, Senile Plaques and Astrocytes in the Hippocampal Subdivisions and Entorhinal Cortex in Alzheimer's Disease, Normal Controls and non-Alzheimer Neuropsychiatric Diseases." Psychiatry and Clinical Neurosciences, vol. 52, no. 6, 1998, pp. 593-9.
Muramori F, Kobayashi K, Nakamura I. A quantitative study of neurofibrillary tangles, senile plaques and astrocytes in the hippocampal subdivisions and entorhinal cortex in Alzheimer's disease, normal controls and non-Alzheimer neuropsychiatric diseases. Psychiatry Clin Neurosci. 1998;52(6):593-9.
Muramori, F., Kobayashi, K., & Nakamura, I. (1998). A quantitative study of neurofibrillary tangles, senile plaques and astrocytes in the hippocampal subdivisions and entorhinal cortex in Alzheimer's disease, normal controls and non-Alzheimer neuropsychiatric diseases. Psychiatry and Clinical Neurosciences, 52(6), 593-9.
Muramori F, Kobayashi K, Nakamura I. A Quantitative Study of Neurofibrillary Tangles, Senile Plaques and Astrocytes in the Hippocampal Subdivisions and Entorhinal Cortex in Alzheimer's Disease, Normal Controls and non-Alzheimer Neuropsychiatric Diseases. Psychiatry Clin Neurosci. 1998;52(6):593-9. PubMed PMID: 9895207.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A quantitative study of neurofibrillary tangles, senile plaques and astrocytes in the hippocampal subdivisions and entorhinal cortex in Alzheimer's disease, normal controls and non-Alzheimer neuropsychiatric diseases. AU - Muramori,F, AU - Kobayashi,K, AU - Nakamura,I, PY - 1999/1/23/pubmed PY - 1999/1/23/medline PY - 1999/1/23/entrez SP - 593 EP - 9 JF - Psychiatry and clinical neurosciences JO - Psychiatry Clin. Neurosci. VL - 52 IS - 6 N2 - The present quantitative study was performed in order to discriminate pathological substrates for dementia from Alzheimer changes in normal controls (NC) and non-Alzheimer neuropsychiatric diseases (NAND). Regional densities of senile plaques (SP), neurofibrillary tangles (NFT) and astrocytes in the cornu ammonis (CA), subiculum and entorhinal cortex were measured and differences in these densities among Alzheimer's disease (AD), NAND and NC were statistically compared. Densities of NFT in the CA and subiculum were significantly higher in AD than in NAND, and densities of SP in all regions were significantly higher in AD than in NAND. Similarly, NFT density in the subiculum and SP density in all regions were higher in AD than in NC. Regional densities of astrocytes in most regions were closely correlated with those of Alzheimer changes. In conclusion, the attribution of the Alzheimer changes, particularly of NFT, to dementia is neglected when they are confined to the entorhinal cortex. However, the attribution of the Alzheimer changes to dementia should be appreciated when they spread from the entorhinal cortex to the subiculum and/or CA. SN - 1323-1316 UR - https://www.unboundmedicine.com/medline/citation/9895207/A_quantitative_study_of_neurofibrillary_tangles_senile_plaques_and_astrocytes_in_the_hippocampal_subdivisions_and_entorhinal_cortex_in_Alzheimer's_disease_normal_controls_and_non_Alzheimer_neuropsychiatric_diseases_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1323-1316&date=1998&volume=52&issue=6&spage=593 DB - PRIME DP - Unbound Medicine ER -