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Dietary fiber and the risk of colorectal cancer and adenoma in women.
N Engl J Med 1999; 340(3):169-76NEJM

Abstract

BACKGROUND

A high intake of dietary fiber has been thought to reduce the risk of colorectal cancer and adenoma.

METHODS

We conducted a prospective study of 88,757 women, who were 34 to 59 years old and had no history of cancer, inflammatory bowel disease, or familial polyposis, who completed a dietary questionnaire in 1980. During a 16-year follow-up period, 787 cases of colorectal cancer were documented. In addition, 1012 patients with adenomas of the distal colon and rectum were found among 27,530 participants who underwent endoscopy during the follow-up period.

RESULTS

After adjustment for age, established risk factors, and total energy intake, we found no association between the intake of dietary fiber and the risk of colorectal cancer; the relative risk for the highest as compared with the lowest quintile group with respect to fiber intake was 0.95 (95 percent confidence interval, 0.73 to 1.25). No protective effect of dietary fiber was observed when we omitted, adjustment for total energy intake, when events during the first six years of follow-up were excluded, or when we excluded women who altered their fiber intake during the follow-up period. No significant association between fiber intake and the risk of colorectal adenoma was found.

CONCLUSIONS

Our data do not support the existence of an important protective effect of dietary fiber against colorectal cancer or adenoma.

Authors+Show Affiliations

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9895396

Citation

Fuchs, C S., et al. "Dietary Fiber and the Risk of Colorectal Cancer and Adenoma in Women." The New England Journal of Medicine, vol. 340, no. 3, 1999, pp. 169-76.
Fuchs CS, Giovannucci EL, Colditz GA, et al. Dietary fiber and the risk of colorectal cancer and adenoma in women. N Engl J Med. 1999;340(3):169-76.
Fuchs, C. S., Giovannucci, E. L., Colditz, G. A., Hunter, D. J., Stampfer, M. J., Rosner, B., ... Willett, W. C. (1999). Dietary fiber and the risk of colorectal cancer and adenoma in women. The New England Journal of Medicine, 340(3), pp. 169-76.
Fuchs CS, et al. Dietary Fiber and the Risk of Colorectal Cancer and Adenoma in Women. N Engl J Med. 1999 Jan 21;340(3):169-76. PubMed PMID: 9895396.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fiber and the risk of colorectal cancer and adenoma in women. AU - Fuchs,C S, AU - Giovannucci,E L, AU - Colditz,G A, AU - Hunter,D J, AU - Stampfer,M J, AU - Rosner,B, AU - Speizer,F E, AU - Willett,W C, PY - 1999/1/23/pubmed PY - 1999/1/23/medline PY - 1999/1/23/entrez SP - 169 EP - 76 JF - The New England journal of medicine JO - N. Engl. J. Med. VL - 340 IS - 3 N2 - BACKGROUND: A high intake of dietary fiber has been thought to reduce the risk of colorectal cancer and adenoma. METHODS: We conducted a prospective study of 88,757 women, who were 34 to 59 years old and had no history of cancer, inflammatory bowel disease, or familial polyposis, who completed a dietary questionnaire in 1980. During a 16-year follow-up period, 787 cases of colorectal cancer were documented. In addition, 1012 patients with adenomas of the distal colon and rectum were found among 27,530 participants who underwent endoscopy during the follow-up period. RESULTS: After adjustment for age, established risk factors, and total energy intake, we found no association between the intake of dietary fiber and the risk of colorectal cancer; the relative risk for the highest as compared with the lowest quintile group with respect to fiber intake was 0.95 (95 percent confidence interval, 0.73 to 1.25). No protective effect of dietary fiber was observed when we omitted, adjustment for total energy intake, when events during the first six years of follow-up were excluded, or when we excluded women who altered their fiber intake during the follow-up period. No significant association between fiber intake and the risk of colorectal adenoma was found. CONCLUSIONS: Our data do not support the existence of an important protective effect of dietary fiber against colorectal cancer or adenoma. SN - 0028-4793 UR - https://www.unboundmedicine.com/medline/citation/9895396/Dietary_fiber_and_the_risk_of_colorectal_cancer_and_adenoma_in_women_ L2 - http://www.nejm.org/doi/full/10.1056/NEJM199901213400301?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -