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Acute haemodynamic effects of labetalol and its subsequent use of an oral hypotensive agent.
Br J Clin Pharmacol. 1976 Aug; 3(4 Suppl 3):789-93.BJ

Abstract

1 Fourteen patients whose lying diastolic blood pressure was persistently 110 mmHg or greater were given labetalol 0.5--1 mg/kg intravenously. 2 The maximum hypotensive effect developed between 20 and 40 min, and on average lasted 3 h. The lying systolic mean blood pressure fell by 30 mmHg and the lying diastolic blood pressure by 17 mmHg (P less than 0.001). 3 This acute hypotensive effect was associated with a significant reduction in the peripheral resistance (P less than 0.02). The hypotension was not associated with significant secondary changes in the stroke volume or pulse rate. 4 The above 14 patients plus 1 additional subject received labetalol orally at a daily dose ranging from 150-2400 mg. The mean lying systolic blood pressure fell by 22 mmHg (P less than0.01) and the mean lying diastolic blood pressure by 26 mmHg (P less than 0.001). The standing values were similar and postural hypotension at this dose did not develop. There was no significant change in the pulse rate. 5 Renal function was monitored by estimates of plasma creatinine and creatinine clearance. Some patients were followed for 2 yr and others for a few months. With the long-term patients, there was no significant reduction in either measurement although in a few patients a slight reduction in creatinine clearance was observed.

Authors

Joekes AM
No affiliation info available
Thompson FD
No affiliation info available

MeSH

Administration, OralAntihypertensive AgentsBlood PressureCardiac OutputCreatinineDrug Administration ScheduleEthanolaminesFemaleFollow-Up StudiesHemodynamicsHumansHypertensionInjections, IntravenousKidneyLabetalolPregnancyPulseVascular Resistance

Pub Type(s)

Journal Article

Language

eng

PubMed ID

990156

Citation

Joekes, A M., and F D. Thompson. "Acute Haemodynamic Effects of Labetalol and Its Subsequent Use of an Oral Hypotensive Agent." British Journal of Clinical Pharmacology, vol. 3, no. 4 Suppl 3, 1976, pp. 789-93.
Joekes AM, Thompson FD. Acute haemodynamic effects of labetalol and its subsequent use of an oral hypotensive agent. Br J Clin Pharmacol. 1976;3(4 Suppl 3):789-93.
Joekes, A. M., & Thompson, F. D. (1976). Acute haemodynamic effects of labetalol and its subsequent use of an oral hypotensive agent. British Journal of Clinical Pharmacology, 3(4 Suppl 3), 789-93.
Joekes AM, Thompson FD. Acute Haemodynamic Effects of Labetalol and Its Subsequent Use of an Oral Hypotensive Agent. Br J Clin Pharmacol. 1976;3(4 Suppl 3):789-93. PubMed PMID: 990156.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute haemodynamic effects of labetalol and its subsequent use of an oral hypotensive agent. AU - Joekes,A M, AU - Thompson,F D, PY - 1976/8/1/pubmed PY - 1976/8/1/medline PY - 1976/8/1/entrez SP - 789 EP - 93 JF - British journal of clinical pharmacology JO - Br J Clin Pharmacol VL - 3 IS - 4 Suppl 3 N2 - 1 Fourteen patients whose lying diastolic blood pressure was persistently 110 mmHg or greater were given labetalol 0.5--1 mg/kg intravenously. 2 The maximum hypotensive effect developed between 20 and 40 min, and on average lasted 3 h. The lying systolic mean blood pressure fell by 30 mmHg and the lying diastolic blood pressure by 17 mmHg (P less than 0.001). 3 This acute hypotensive effect was associated with a significant reduction in the peripheral resistance (P less than 0.02). The hypotension was not associated with significant secondary changes in the stroke volume or pulse rate. 4 The above 14 patients plus 1 additional subject received labetalol orally at a daily dose ranging from 150-2400 mg. The mean lying systolic blood pressure fell by 22 mmHg (P less than0.01) and the mean lying diastolic blood pressure by 26 mmHg (P less than 0.001). The standing values were similar and postural hypotension at this dose did not develop. There was no significant change in the pulse rate. 5 Renal function was monitored by estimates of plasma creatinine and creatinine clearance. Some patients were followed for 2 yr and others for a few months. With the long-term patients, there was no significant reduction in either measurement although in a few patients a slight reduction in creatinine clearance was observed. SN - 0306-5251 UR - https://www.unboundmedicine.com/medline/citation/990156/Acute_haemodynamic_effects_of_labetalol_and_its_subsequent_use_of_an_oral_hypotensive_agent_ DB - PRIME DP - Unbound Medicine ER -