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Acute effect of intravenous labetalol in the treatment of systemic arterial hypertension.
Br J Clin Pharmacol. 1976 Aug; 3(4 Suppl 3):805-8.BJ

Abstract

1 The acute anti-hypertensive effect of intravenously administered labetalol, a combined alpha- and beta-adrenoreceptor antagonist, has been assessed in a pilot study involving 17 hypertensive patients. 2 In 11 patients with mild to moderately severe hypertension, there was a decrease in mean arterial pressure (24 mmHg) after a single intravenous dose of 50 mg labetalol. The peak response occurred approximately 4 min after administration of the drug. 3 In six patients with severe hypertension, there was a reduction in mean arterial pressure of 19 mmHg, but this was achieved after a further 50-mg dose administered 30 min after the initial injection. 4 In neither group was there any clinically significant decrease in heart rate, and drug-related side-effects were insignificant. 5 Labetalol reduced the blood pressure when administered intravenously and thus merits further investigation as a treatment for acute hypertensive crises.

Authors

Ronne-Rasmussen JO
No affiliation info available
Andersen GS
No affiliation info available
Jensen NB
No affiliation info available
Andersson E
No affiliation info available

MeSH

Acute DiseaseAdultAgedBlood PressureDrug Administration ScheduleDrug EvaluationEthanolaminesFemaleHumansHypertensionInjections, IntravenousLabetalolMaleMiddle Aged

Pub Type(s)

Journal Article

Language

eng

PubMed ID

990157

Citation

Ronne-Rasmussen, J O., et al. "Acute Effect of Intravenous Labetalol in the Treatment of Systemic Arterial Hypertension." British Journal of Clinical Pharmacology, vol. 3, no. 4 Suppl 3, 1976, pp. 805-8.
Ronne-Rasmussen JO, Andersen GS, Jensen NB, et al. Acute effect of intravenous labetalol in the treatment of systemic arterial hypertension. Br J Clin Pharmacol. 1976;3(4 Suppl 3):805-8.
Ronne-Rasmussen, J. O., Andersen, G. S., Jensen, N. B., & Andersson, E. (1976). Acute effect of intravenous labetalol in the treatment of systemic arterial hypertension. British Journal of Clinical Pharmacology, 3(4 Suppl 3), 805-8.
Ronne-Rasmussen JO, et al. Acute Effect of Intravenous Labetalol in the Treatment of Systemic Arterial Hypertension. Br J Clin Pharmacol. 1976;3(4 Suppl 3):805-8. PubMed PMID: 990157.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute effect of intravenous labetalol in the treatment of systemic arterial hypertension. AU - Ronne-Rasmussen,J O, AU - Andersen,G S, AU - Jensen,N B, AU - Andersson,E, PY - 1976/8/1/pubmed PY - 1976/8/1/medline PY - 1976/8/1/entrez SP - 805 EP - 8 JF - British journal of clinical pharmacology JO - Br J Clin Pharmacol VL - 3 IS - 4 Suppl 3 N2 - 1 The acute anti-hypertensive effect of intravenously administered labetalol, a combined alpha- and beta-adrenoreceptor antagonist, has been assessed in a pilot study involving 17 hypertensive patients. 2 In 11 patients with mild to moderately severe hypertension, there was a decrease in mean arterial pressure (24 mmHg) after a single intravenous dose of 50 mg labetalol. The peak response occurred approximately 4 min after administration of the drug. 3 In six patients with severe hypertension, there was a reduction in mean arterial pressure of 19 mmHg, but this was achieved after a further 50-mg dose administered 30 min after the initial injection. 4 In neither group was there any clinically significant decrease in heart rate, and drug-related side-effects were insignificant. 5 Labetalol reduced the blood pressure when administered intravenously and thus merits further investigation as a treatment for acute hypertensive crises. SN - 0306-5251 UR - https://www.unboundmedicine.com/medline/citation/990157/Acute_effect_of_intravenous_labetalol_in_the_treatment_of_systemic_arterial_hypertension_ DB - PRIME DP - Unbound Medicine ER -