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    Sucralfate in the prevention of radiation-induced oral mucositis.

    Abstract

    Radiotherapy-induced mucositis decreases the quality of life by impairing eating, swallowing, and talking and by disturbing sleep. Mucositis may also predispose to local and systemic infections and may cause interruption of radiotherapy course. We studied the efficacy of sucralfate suspension in the prevention and management of oral mucositis and pain during radiotherapy in a double-blind, placebo-controlled, randomized, prospective trial. Twenty-eight patients with head and neck cancer were included in the study. The patients were randomized to use either sucralfate mouth washing (n = 18) or placebo washing (n = 10) during irradiation. Oral mucositis and symptoms were assessed by the same physician using Radiation Therapy Oncology Group Acute Radiation Morbidity Scoring criteria. All patients developed varying degrees of radiation-induced mucositis. Grade 4 mucositis was not encountered in any patient. One patient had grade 1, seven patients grade 2, and two patients grade 3 mucositis in placebo group. In sucralfate group, nine patients each had grade 1 and grade 2 with no grade 3 mucositis. Patients in the sucralfate group experienced significantly lower degree of mucositis than placebo group (p < 0.05). Sucralfate mouth washing is beneficial in decreasing the intensity of radiation-induced mucositis and oral discomfort. It is cheap, easy to administer with no serious side effect, and may be routinely used in patients receiving head and neck radiotherapy.

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    • Grapherence [↓13]

    Authors+Show Affiliations

    Cengiz M
    ,

    Department of Radiation Oncology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

    Ozyar E
    ,
    Oztürk D
    ,
    Akyol F
    ,
    Atahan IL
    ,
    Hayran M

    Source

    MeSH

    Double-Blind Method
    Female
    Gastrointestinal Agents
    Head and Neck Neoplasms
    Humans
    Male
    Middle Aged
    Mouth Mucosa
    Mouthwashes
    Pharyngitis
    Prospective Studies
    Radiation Injuries
    Radiotherapy, High-Energy
    Stomatitis
    Sucralfate

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    9916664

    Citation

    * When formatting your citation, note that all book, journal, and database titles should be italicized* Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Sucralfate in the prevention of radiation-induced oral mucositis. AU - Cengiz,M, AU - Ozyar,E, AU - Oztürk,D, AU - Akyol,F, AU - Atahan,I L, AU - Hayran,M, PY - 1999/1/23/pubmed PY - 1999/1/23/medline PY - 1999/1/23/entrez SP - 40 EP - 3 JF - Journal of clinical gastroenterology JO - J. Clin. Gastroenterol. VL - 28 IS - 1 N2 - Radiotherapy-induced mucositis decreases the quality of life by impairing eating, swallowing, and talking and by disturbing sleep. Mucositis may also predispose to local and systemic infections and may cause interruption of radiotherapy course. We studied the efficacy of sucralfate suspension in the prevention and management of oral mucositis and pain during radiotherapy in a double-blind, placebo-controlled, randomized, prospective trial. Twenty-eight patients with head and neck cancer were included in the study. The patients were randomized to use either sucralfate mouth washing (n = 18) or placebo washing (n = 10) during irradiation. Oral mucositis and symptoms were assessed by the same physician using Radiation Therapy Oncology Group Acute Radiation Morbidity Scoring criteria. All patients developed varying degrees of radiation-induced mucositis. Grade 4 mucositis was not encountered in any patient. One patient had grade 1, seven patients grade 2, and two patients grade 3 mucositis in placebo group. In sucralfate group, nine patients each had grade 1 and grade 2 with no grade 3 mucositis. Patients in the sucralfate group experienced significantly lower degree of mucositis than placebo group (p < 0.05). Sucralfate mouth washing is beneficial in decreasing the intensity of radiation-induced mucositis and oral discomfort. It is cheap, easy to administer with no serious side effect, and may be routinely used in patients receiving head and neck radiotherapy. SN - 0192-0790 UR - https://www.unboundmedicine.com/medline/citation/9916664/Sucralfate_in_the_prevention_of_radiation_induced_oral_mucositis_ L2 - http://Insights.ovid.com/pubmed?pmid=9916664 DB - PRIME DP - Unbound Medicine ER -
    Grapherence [↓13]

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