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Sucralfate in the prevention of radiation-induced oral mucositis.

Abstract

Radiotherapy-induced mucositis decreases the quality of life by impairing eating, swallowing, and talking and by disturbing sleep. Mucositis may also predispose to local and systemic infections and may cause interruption of radiotherapy course. We studied the efficacy of sucralfate suspension in the prevention and management of oral mucositis and pain during radiotherapy in a double-blind, placebo-controlled, randomized, prospective trial. Twenty-eight patients with head and neck cancer were included in the study. The patients were randomized to use either sucralfate mouth washing (n = 18) or placebo washing (n = 10) during irradiation. Oral mucositis and symptoms were assessed by the same physician using Radiation Therapy Oncology Group Acute Radiation Morbidity Scoring criteria. All patients developed varying degrees of radiation-induced mucositis. Grade 4 mucositis was not encountered in any patient. One patient had grade 1, seven patients grade 2, and two patients grade 3 mucositis in placebo group. In sucralfate group, nine patients each had grade 1 and grade 2 with no grade 3 mucositis. Patients in the sucralfate group experienced significantly lower degree of mucositis than placebo group (p < 0.05). Sucralfate mouth washing is beneficial in decreasing the intensity of radiation-induced mucositis and oral discomfort. It is cheap, easy to administer with no serious side effect, and may be routinely used in patients receiving head and neck radiotherapy.

Links

Publisher Full Text

Grapherence [↓13]

Authors+Show Affiliations

Cengiz M

Department of Radiation Oncology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Source

Journal of clinical gastroenterology 28:1 1999 Jan pg 40-3

MeSH

Double-Blind Method
Female
Gastrointestinal Agents
Head and Neck Neoplasms
Humans
Male
Middle Aged
Mouth Mucosa
Mouthwashes
Pharyngitis
Prospective Studies
Radiation Injuries
Radiotherapy, High-Energy
Stomatitis
Sucralfate

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

9916664

Citation

Cengiz M et al: "Sucralfate in the prevention of radiation-induced oral mucositis." Journal of clinical gastroenterology, vol. 28, no. 1, 1999, pp. 40-3, https://www.unboundmedicine.com/medline/citation/9916664/Sucralfate_in_the_prevention_of_radiation_induced_oral_mucositis_. Accessed November 19, 2018.

Cengiz M, Ozyar E, Oztürk D, et al. Sucralfate in the prevention of radiation-induced oral mucositis. J Clin Gastroenterol 1999;28(1):40-3 https://www.unboundmedicine.com/medline/citation/9916664/Sucralfate_in_the_prevention_of_radiation_induced_oral_mucositis_. Accessed November 19, 2018.

Cengiz M & Ozyar E & Oztürk D, et al. (1999). Sucralfate in the prevention of radiation-induced oral mucositis. Journal of clinical gastroenterology, 28, pp. 40-3.

Cengiz M et al. Sucralfate in the prevention of radiation-induced oral mucositis. J Clin Gastroenterol. 1999;28:40-3

TY - JOUR T1 - Sucralfate in the prevention of radiation-induced oral mucositis. AU - Cengiz,M, AU - Ozyar,E, AU - Oztürk,D, AU - Akyol,F, AU - Atahan,I L, AU - Hayran,M, PY - 1999/1/23/pubmed PY - 1999/1/23/medline PY - 1999/1/23/entrez SP - 40 EP - 3 JF - Journal of clinical gastroenterology JO - J. Clin. Gastroenterol. VL - 28 IS - 1 N2 - Radiotherapy-induced mucositis decreases the quality of life by impairing eating, swallowing, and talking and by disturbing sleep. Mucositis may also predispose to local and systemic infections and may cause interruption of radiotherapy course. We studied the efficacy of sucralfate suspension in the prevention and management of oral mucositis and pain during radiotherapy in a double-blind, placebo-controlled, randomized, prospective trial. Twenty-eight patients with head and neck cancer were included in the study. The patients were randomized to use either sucralfate mouth washing (n = 18) or placebo washing (n = 10) during irradiation. Oral mucositis and symptoms were assessed by the same physician using Radiation Therapy Oncology Group Acute Radiation Morbidity Scoring criteria. All patients developed varying degrees of radiation-induced mucositis. Grade 4 mucositis was not encountered in any patient. One patient had grade 1, seven patients grade 2, and two patients grade 3 mucositis in placebo group. In sucralfate group, nine patients each had grade 1 and grade 2 with no grade 3 mucositis. Patients in the sucralfate group experienced significantly lower degree of mucositis than placebo group (p < 0.05). Sucralfate mouth washing is beneficial in decreasing the intensity of radiation-induced mucositis and oral discomfort. It is cheap, easy to administer with no serious side effect, and may be routinely used in patients receiving head and neck radiotherapy. SN - 0192-0790 UR - https://www.unboundmedicine.com/medline/citation/9916664/Sucralfate_in_the_prevention_of_radiation_induced_oral_mucositis_ L2 - http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0192-0790&volume=28&issue=1&spage=40 ER -