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Identification of quantitative trait loci governing arthritis severity and humoral responses in the murine model of Lyme disease.
J Immunol. 1999 Jan 15; 162(2):948-56.JI

Abstract

A spectrum of disease severity has been observed in patients with Lyme disease, with approximately 60% of untreated individuals developing arthritis. The murine model of Lyme disease has provided strong evidence that the genetic composition of the host influences the severity of arthritis following infection with Borrelia burgdorferi: infected C3H mice develop severe arthritis while infected C57BL/6N mice develop mild arthritis. Regions of the mouse genome controlling arthritis severity and humoral responses during B. burgdorferi infection were identified in the F2 intercross generation of C3H/HeNCr and C57BL/6NCr mice. Rear ankle swelling measurements identified quantitative trait loci (QTL) on chromosomes 4 and 5, while histopathological scoring identified QTL on a unique region of chromosome 5 and on chromosome 11. The identification of QTL unique for ankle swelling or histopathological severity suggests that processes under distinct genetic control are responsible for these two manifestations of Lyme arthritis. Additional QTL that control the levels of circulating Igs induced by B. burgdorferi infection were identified on chromosomes 6, 9, 11, 12, and 17. Interestingly, the magnitude of the humoral response was not correlated with the severity of arthritis in infected F2 mice. This work defines several genetic loci that regulate either the severity of arthritis or the magnitude of humoral responses to B. burgdorferi infection in mice, with implications toward understanding the host-pathogen interactions involved in disease development.

Authors+Show Affiliations

Department of Pathology, University of Utah, Salt Lake City 84132, USA. janis.weis@path.med.utah.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9916719

Citation

Weis, J J., et al. "Identification of Quantitative Trait Loci Governing Arthritis Severity and Humoral Responses in the Murine Model of Lyme Disease." Journal of Immunology (Baltimore, Md. : 1950), vol. 162, no. 2, 1999, pp. 948-56.
Weis JJ, McCracken BA, Ma Y, et al. Identification of quantitative trait loci governing arthritis severity and humoral responses in the murine model of Lyme disease. J Immunol. 1999;162(2):948-56.
Weis, J. J., McCracken, B. A., Ma, Y., Fairbairn, D., Roper, R. J., Morrison, T. B., Weis, J. H., Zachary, J. F., Doerge, R. W., & Teuscher, C. (1999). Identification of quantitative trait loci governing arthritis severity and humoral responses in the murine model of Lyme disease. Journal of Immunology (Baltimore, Md. : 1950), 162(2), 948-56.
Weis JJ, et al. Identification of Quantitative Trait Loci Governing Arthritis Severity and Humoral Responses in the Murine Model of Lyme Disease. J Immunol. 1999 Jan 15;162(2):948-56. PubMed PMID: 9916719.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Identification of quantitative trait loci governing arthritis severity and humoral responses in the murine model of Lyme disease. AU - Weis,J J, AU - McCracken,B A, AU - Ma,Y, AU - Fairbairn,D, AU - Roper,R J, AU - Morrison,T B, AU - Weis,J H, AU - Zachary,J F, AU - Doerge,R W, AU - Teuscher,C, PY - 1999/1/23/pubmed PY - 1999/1/23/medline PY - 1999/1/23/entrez SP - 948 EP - 56 JF - Journal of immunology (Baltimore, Md. : 1950) JO - J. Immunol. VL - 162 IS - 2 N2 - A spectrum of disease severity has been observed in patients with Lyme disease, with approximately 60% of untreated individuals developing arthritis. The murine model of Lyme disease has provided strong evidence that the genetic composition of the host influences the severity of arthritis following infection with Borrelia burgdorferi: infected C3H mice develop severe arthritis while infected C57BL/6N mice develop mild arthritis. Regions of the mouse genome controlling arthritis severity and humoral responses during B. burgdorferi infection were identified in the F2 intercross generation of C3H/HeNCr and C57BL/6NCr mice. Rear ankle swelling measurements identified quantitative trait loci (QTL) on chromosomes 4 and 5, while histopathological scoring identified QTL on a unique region of chromosome 5 and on chromosome 11. The identification of QTL unique for ankle swelling or histopathological severity suggests that processes under distinct genetic control are responsible for these two manifestations of Lyme arthritis. Additional QTL that control the levels of circulating Igs induced by B. burgdorferi infection were identified on chromosomes 6, 9, 11, 12, and 17. Interestingly, the magnitude of the humoral response was not correlated with the severity of arthritis in infected F2 mice. This work defines several genetic loci that regulate either the severity of arthritis or the magnitude of humoral responses to B. burgdorferi infection in mice, with implications toward understanding the host-pathogen interactions involved in disease development. SN - 0022-1767 UR - https://www.unboundmedicine.com/medline/citation/9916719/Identification_of_quantitative_trait_loci_governing_arthritis_severity_and_humoral_responses_in_the_murine_model_of_Lyme_disease_ L2 - http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=9916719 DB - PRIME DP - Unbound Medicine ER -