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A severe adverse reaction to mefloquine and chloroquine prophylaxis.
Aust Fam Physician. 1998 Dec; 27(12):1119-20.AF

Abstract

A 23 year old man with no history of neurological or psychiatric illness ingested three weekly 228 mg doses of mefloquine base (250 mg salt) as malaria prophylaxis while in India. He experienced an increasingly severe adverse reaction after each dose, including symptoms of paranoia, hallucinations, and suicidal ideation. The man discontinued mefloquine and continued malaria prophylaxis with chloroquine. Shortly after the first 300 mg dose of chloroquine base (500 mg chloroquine phosphate salt), symptoms acutely intensified and became debilitating. Severe symptoms persisted for 12 months following the discontinuation of both antimalarial drugs.

Authors+Show Affiliations

School of Medicine, Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

9919736

Citation

Lysack, J T., et al. "A Severe Adverse Reaction to Mefloquine and Chloroquine Prophylaxis." Australian Family Physician, vol. 27, no. 12, 1998, pp. 1119-20.
Lysack JT, Lysack CL, Kvern BL. A severe adverse reaction to mefloquine and chloroquine prophylaxis. Aust Fam Physician. 1998;27(12):1119-20.
Lysack, J. T., Lysack, C. L., & Kvern, B. L. (1998). A severe adverse reaction to mefloquine and chloroquine prophylaxis. Australian Family Physician, 27(12), 1119-20.
Lysack JT, Lysack CL, Kvern BL. A Severe Adverse Reaction to Mefloquine and Chloroquine Prophylaxis. Aust Fam Physician. 1998;27(12):1119-20. PubMed PMID: 9919736.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A severe adverse reaction to mefloquine and chloroquine prophylaxis. AU - Lysack,J T, AU - Lysack,C L, AU - Kvern,B L, PY - 1999/1/27/pubmed PY - 1999/1/27/medline PY - 1999/1/27/entrez SP - 1119 EP - 20 JF - Australian family physician JO - Aust Fam Physician VL - 27 IS - 12 N2 - A 23 year old man with no history of neurological or psychiatric illness ingested three weekly 228 mg doses of mefloquine base (250 mg salt) as malaria prophylaxis while in India. He experienced an increasingly severe adverse reaction after each dose, including symptoms of paranoia, hallucinations, and suicidal ideation. The man discontinued mefloquine and continued malaria prophylaxis with chloroquine. Shortly after the first 300 mg dose of chloroquine base (500 mg chloroquine phosphate salt), symptoms acutely intensified and became debilitating. Severe symptoms persisted for 12 months following the discontinuation of both antimalarial drugs. SN - 0300-8495 UR - https://www.unboundmedicine.com/medline/citation/9919736/A_severe_adverse_reaction_to_mefloquine_and_chloroquine_prophylaxis_ L2 - https://medlineplus.gov/drugreactions.html DB - PRIME DP - Unbound Medicine ER -