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Combined genotypes of CCR5, CCR2, SDF1, and HLA genes can predict the long-term nonprogressor status in human immunodeficiency virus-1-infected individuals.
Blood. 1999 Feb 01; 93(3):936-41.Blood

Abstract

Human immunodeficiency virus (HIV)-1-infected long-term nonprogressors (LT-NP) represent less than 5% of HIV-1-infected patients. In this work, we tried to understand whether combined genotypes of CCR5-triangle up32, CCR2-64I, SDF1-3'A and HLA alleles can predict the LT-NP status. Among the chemokine receptor genotypes, only the frequency of the CCR5-triangle up32 allele was significantly higher in LT-NP compared with the group of standard progressors. The predominant HLA alleles in LT-NP were HLA-A3, HLA-B14, HLA-B17, HLA-B27, HLA-DR6, and HLA-DR7. A combination of both HLA and chemokine receptor genotypes integrated in a multivariate logistic regression model showed that if a subject is heterozygous for CCR5-triangle up32 and homozygous for SDF1 wild type, his odds of being LT-NP are increased by 16-fold, by 47-fold when a HLA-B27 allele is present with HLA-DR6 absent, and by 47-fold also if at least three of the following alleles are present: HLA-A3, HLA-B14, HLA-B17, HLA-DR7. This model allowed a correct classification of 70% of LT-NPs and 81% of progressors, suggesting that the host's genetic background plays an important role in the evolution of HIV-1. The chemokine receptor and chemokine genes along with the HLA genotype can serve as predictors of HIV-1 outcome for classification of HIV-1-infected subjects as LT-NPs or progressors.

Authors+Show Affiliations

Laboratoire d'Immunologie Cellulaire et Tissulaire, UMR CNRS 7627, Hôpital Pitié-Salpêtrière, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9920843

Citation

Magierowska, M, et al. "Combined Genotypes of CCR5, CCR2, SDF1, and HLA Genes Can Predict the Long-term Nonprogressor Status in Human Immunodeficiency Virus-1-infected Individuals." Blood, vol. 93, no. 3, 1999, pp. 936-41.
Magierowska M, Theodorou I, Debré P, et al. Combined genotypes of CCR5, CCR2, SDF1, and HLA genes can predict the long-term nonprogressor status in human immunodeficiency virus-1-infected individuals. Blood. 1999;93(3):936-41.
Magierowska, M., Theodorou, I., Debré, P., Sanson, F., Autran, B., Rivière, Y., Charron, D., & Costagliola, D. (1999). Combined genotypes of CCR5, CCR2, SDF1, and HLA genes can predict the long-term nonprogressor status in human immunodeficiency virus-1-infected individuals. Blood, 93(3), 936-41.
Magierowska M, et al. Combined Genotypes of CCR5, CCR2, SDF1, and HLA Genes Can Predict the Long-term Nonprogressor Status in Human Immunodeficiency Virus-1-infected Individuals. Blood. 1999 Feb 1;93(3):936-41. PubMed PMID: 9920843.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined genotypes of CCR5, CCR2, SDF1, and HLA genes can predict the long-term nonprogressor status in human immunodeficiency virus-1-infected individuals. AU - Magierowska,M, AU - Theodorou,I, AU - Debré,P, AU - Sanson,F, AU - Autran,B, AU - Rivière,Y, AU - Charron,D, AU - Costagliola,D, PY - 1999/1/28/pubmed PY - 1999/1/28/medline PY - 1999/1/28/entrez SP - 936 EP - 41 JF - Blood JO - Blood VL - 93 IS - 3 N2 - Human immunodeficiency virus (HIV)-1-infected long-term nonprogressors (LT-NP) represent less than 5% of HIV-1-infected patients. In this work, we tried to understand whether combined genotypes of CCR5-triangle up32, CCR2-64I, SDF1-3'A and HLA alleles can predict the LT-NP status. Among the chemokine receptor genotypes, only the frequency of the CCR5-triangle up32 allele was significantly higher in LT-NP compared with the group of standard progressors. The predominant HLA alleles in LT-NP were HLA-A3, HLA-B14, HLA-B17, HLA-B27, HLA-DR6, and HLA-DR7. A combination of both HLA and chemokine receptor genotypes integrated in a multivariate logistic regression model showed that if a subject is heterozygous for CCR5-triangle up32 and homozygous for SDF1 wild type, his odds of being LT-NP are increased by 16-fold, by 47-fold when a HLA-B27 allele is present with HLA-DR6 absent, and by 47-fold also if at least three of the following alleles are present: HLA-A3, HLA-B14, HLA-B17, HLA-DR7. This model allowed a correct classification of 70% of LT-NPs and 81% of progressors, suggesting that the host's genetic background plays an important role in the evolution of HIV-1. The chemokine receptor and chemokine genes along with the HLA genotype can serve as predictors of HIV-1 outcome for classification of HIV-1-infected subjects as LT-NPs or progressors. SN - 0006-4971 UR - https://www.unboundmedicine.com/medline/citation/9920843/Combined_genotypes_of_CCR5_CCR2_SDF1_and_HLA_genes_can_predict_the_long_term_nonprogressor_status_in_human_immunodeficiency_virus_1_infected_individuals_ L2 - http://hivinsite.ucsf.edu/InSite?page=kb-03-03-05 DB - PRIME DP - Unbound Medicine ER -