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Prevalence of various respiratory viruses in the middle ear during acute otitis media.
N Engl J Med. 1999 Jan 28; 340(4):260-4.NEJM

Abstract

BACKGROUND

Vaccines against respiratory viruses may be able to reduce the frequency of acute otitis media. Although the role of respiratory viruses in the pathogenesis of acute otitis media is well established, the relative importance of various viruses is unknown.

METHODS

We determined the prevalence of various respiratory viruses in the middle-ear fluid in 456 children (age, two months to seven years) with acute otitis media. At enrollment and after two to five days of antibiotic therapy, specimens of middle-ear fluid and nasal-wash specimens were obtained for viral and bacterial cultures and the detection of viral antigens. The viral cause of the infections was also assessed by serologic studies of serum samples obtained during the acute illness and convalescence.

RESULTS

A specific viral cause of the respiratory tract infections was identified in 186 of the 456 children (41 percent). Respiratory syncytial virus was the most common virus identified in middle-ear fluid: it was detected in the middle-ear fluid of 48 of the 65 children (74 percent) infected by this virus (P< or =0.04 for the comparison with any other virus). Parainfluenza viruses (15 of 29 children [52 percent]) and influenzaviruses (10 of 24 children [42 percent]) were detected in the middle-ear fluid significantly more often than enteroviruses (3 of 27 children [11 percent]) or adenoviruses (1 of 23 children [4 percent]) (P< or =0.01 for all comparisons).

CONCLUSION

Respiratory syncytial virus is the principal virus invading the middle ear during acute otitis media. An effective vaccine against upper respiratory tract infections caused by respiratory syncytial virus may reduce the incidence of acute otitis media in children.

Authors+Show Affiliations

Department of Pediatrics, University of Texas Medical Branch, Galveston 77555-0371, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9920949

Citation

Heikkinen, T, et al. "Prevalence of Various Respiratory Viruses in the Middle Ear During Acute Otitis Media." The New England Journal of Medicine, vol. 340, no. 4, 1999, pp. 260-4.
Heikkinen T, Thint M, Chonmaitree T. Prevalence of various respiratory viruses in the middle ear during acute otitis media. N Engl J Med. 1999;340(4):260-4.
Heikkinen, T., Thint, M., & Chonmaitree, T. (1999). Prevalence of various respiratory viruses in the middle ear during acute otitis media. The New England Journal of Medicine, 340(4), 260-4.
Heikkinen T, Thint M, Chonmaitree T. Prevalence of Various Respiratory Viruses in the Middle Ear During Acute Otitis Media. N Engl J Med. 1999 Jan 28;340(4):260-4. PubMed PMID: 9920949.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of various respiratory viruses in the middle ear during acute otitis media. AU - Heikkinen,T, AU - Thint,M, AU - Chonmaitree,T, PY - 1999/1/28/pubmed PY - 1999/1/28/medline PY - 1999/1/28/entrez SP - 260 EP - 4 JF - The New England journal of medicine JO - N Engl J Med VL - 340 IS - 4 N2 - BACKGROUND: Vaccines against respiratory viruses may be able to reduce the frequency of acute otitis media. Although the role of respiratory viruses in the pathogenesis of acute otitis media is well established, the relative importance of various viruses is unknown. METHODS: We determined the prevalence of various respiratory viruses in the middle-ear fluid in 456 children (age, two months to seven years) with acute otitis media. At enrollment and after two to five days of antibiotic therapy, specimens of middle-ear fluid and nasal-wash specimens were obtained for viral and bacterial cultures and the detection of viral antigens. The viral cause of the infections was also assessed by serologic studies of serum samples obtained during the acute illness and convalescence. RESULTS: A specific viral cause of the respiratory tract infections was identified in 186 of the 456 children (41 percent). Respiratory syncytial virus was the most common virus identified in middle-ear fluid: it was detected in the middle-ear fluid of 48 of the 65 children (74 percent) infected by this virus (P< or =0.04 for the comparison with any other virus). Parainfluenza viruses (15 of 29 children [52 percent]) and influenzaviruses (10 of 24 children [42 percent]) were detected in the middle-ear fluid significantly more often than enteroviruses (3 of 27 children [11 percent]) or adenoviruses (1 of 23 children [4 percent]) (P< or =0.01 for all comparisons). CONCLUSION: Respiratory syncytial virus is the principal virus invading the middle ear during acute otitis media. An effective vaccine against upper respiratory tract infections caused by respiratory syncytial virus may reduce the incidence of acute otitis media in children. SN - 0028-4793 UR - https://www.unboundmedicine.com/medline/citation/9920949/Prevalence_of_various_respiratory_viruses_in_the_middle_ear_during_acute_otitis_media_ L2 - https://www.nejm.org/doi/10.1056/NEJM199901283400402?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -