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[Melatonin and regulation of the cardiovascular system].

Abstract

Evidence from the last 10 years suggests that melatonin may influence the cardiovascular system. Vascular melatoninergic receptors/sites have been demonstrated and are functionally linked with vasoconstrictor or vasodilatory effects of low (10(-9)-10(-7) M) and high (10(-6)-10(-3) M) melatonin concentrations respectively. Furthermore several other properties of the neurohormone (e.g. sympathetic inhibition) could contribute to cardioprotection. In vivo melatonin beneficially affects the rat cerebrovascular circulation and protects the rat heart following myocardial ischaemia. In this regard, preliminary clinical data report some alteration of the melatoninergic system in human stroke and coronary heart disease. Finally, the suprachiasmatic nucleus and possibly the melatoninergic system may modulate cardiovascular rhythmicity. Clinical cardiovascular data on melatonin treatment are very scarce; the effects of a therapy modulating the melatoninergic system on cardiovascular haemodynamics and rhythmicity under several physiopathological conditions need to be further explored together with the possible impact on cardiovascular morbidity and mortality.

Authors+Show Affiliations

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Division de Thérapeutique Expérimentale, Institut de Recherches Internationales Servier, Courbevoie, France.

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Source

Therapie 53:5 pg 459-65

MeSH

Animals
Cardiovascular Physiological Phenomena
Circadian Rhythm
Clinical Trials as Topic
Hemodynamics
Humans
Melatonin
Rats

Pub Type(s)

English Abstract
Journal Article
Review

Language

fre

PubMed ID

9921038

Citation

Scalbert, E, et al. "[Melatonin and Regulation of the Cardiovascular System]." Therapie, vol. 53, no. 5, 1998, pp. 459-65.
Scalbert E, Guardiola-Lemaître B, Delagrange P. [Melatonin and regulation of the cardiovascular system]. Therapie. 1998;53(5):459-65.
Scalbert, E., Guardiola-Lemaître, B., & Delagrange, P. (1998). [Melatonin and regulation of the cardiovascular system]. Therapie, 53(5), pp. 459-65.
Scalbert E, Guardiola-Lemaître B, Delagrange P. [Melatonin and Regulation of the Cardiovascular System]. Therapie. 1998;53(5):459-65. PubMed PMID: 9921038.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Melatonin and regulation of the cardiovascular system]. AU - Scalbert,E, AU - Guardiola-Lemaître,B, AU - Delagrange,P, PY - 1999/1/28/pubmed PY - 1999/1/28/medline PY - 1999/1/28/entrez SP - 459 EP - 65 JF - Therapie JO - Therapie VL - 53 IS - 5 N2 - Evidence from the last 10 years suggests that melatonin may influence the cardiovascular system. Vascular melatoninergic receptors/sites have been demonstrated and are functionally linked with vasoconstrictor or vasodilatory effects of low (10(-9)-10(-7) M) and high (10(-6)-10(-3) M) melatonin concentrations respectively. Furthermore several other properties of the neurohormone (e.g. sympathetic inhibition) could contribute to cardioprotection. In vivo melatonin beneficially affects the rat cerebrovascular circulation and protects the rat heart following myocardial ischaemia. In this regard, preliminary clinical data report some alteration of the melatoninergic system in human stroke and coronary heart disease. Finally, the suprachiasmatic nucleus and possibly the melatoninergic system may modulate cardiovascular rhythmicity. Clinical cardiovascular data on melatonin treatment are very scarce; the effects of a therapy modulating the melatoninergic system on cardiovascular haemodynamics and rhythmicity under several physiopathological conditions need to be further explored together with the possible impact on cardiovascular morbidity and mortality. SN - 0040-5957 UR - https://www.unboundmedicine.com/medline/citation/9921038/[Melatonin_and_regulation_of_the_cardiovascular_system]_ L2 - https://www.lens.org/lens/search?q=citation_id:9921038 DB - PRIME DP - Unbound Medicine ER -